AIDS: Etiology, Diagnosis, Treatment and Prevention

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Editorial Reviews

John A. Robinson
The number of books on HIV-AIDS, already a surfeit, continues to increase. Some are very good, many are less than pedestrian, and this book falls somewhere in between. The major drawback of encyclopedic texts, especially in the continually evolving HIV arena, is the unavoidable publication delay. This inevitable knowledge gap poses a serious problem for publishers, writers, and readers. Unfortunately, 1996 was a banner year for exciting revelations, not only in the treatment of HIV-AIDS, but for getting off the CD4 dime and moving on to implicating coreceptor(s) for infection. In turn, the latter revelation shed light on genetically dictated resistance to infection. The fact that none of these advances could be adequately addressed in a macrotext revision leads one to question the usefulness of such frequent updating of HIV textbooks. Infectious disease historians might draw a parallel to the syphilis saga at the turn of the century, and one hopes that neurologists will do so with Alzheimer's disease in 2025! After all, most of the clinical fundamentals of HIV-AIDS are now well described and available at multiple levels of reader sophistication. How much more historical and descriptive clinical information could be in the wings? What is needed and now available is rapid access to new HIV understandings by electronic transfer and monthly publications. To the editors' and publisher's credit, an insert detailing the newest strategies of retroviral polytherapy was added, apparently in the terminal stages of publication, but nonetheless, significant scientific discussion on additional subjects ranging from viral load, chemokines, infection resistance, HIV superantigen functions tothe depressing evidence that safe sex practices of gay males are being abandoned, the unexpected clash between AIDS activists and animal rights groups, and two straight years of reported AIDS decreases in the U.S. could not be adequately addressed. The primary audience for this text is clinicians. There are many excellent chapters in this book; almost all the clinical and epidemiologic ones are well written. Others, depending on the eyes of the beholder, may have less luster. The book insists on being multidimensional and, in an apparent attempt to mirror the intermingled sociological, political, public health, and psychosocial ramifications of this epidemic, chapters on the latter are scattered throughout. More than a few readers, but certainly not all, will find the placement in the section on psychosocial aspects of the history of community-based responses to HIV-AIDS from the perspective of an activist somewhat curious. The demons of ideology and political correctness, a distraction in many AIDS works, have been almost completely exorcised, but a few vestiges survive. For example, intravenous drug abuse (IVDA) at one point becomes injection of illicit psychoactive drugs (IIPD) and the mantra drumbeat of increasing heterosexual transmission in the U.S. still appears more often than one would expect. This book is recommended to readers who need a fundamental text in HIV biology, transmission, and clinical outcomes. Infectious disease subspecialists and their allies may benefit more from rapid information transfer sources or annual HIV-AIDS reviews.
Doody's Review Service
Reviewer: John A. Robinson, MD (Loyola University Stritch School of Medicine)
Description: The number of books on HIV-AIDS, already a surfeit, continues to increase. Some are very good, many are less than pedestrian, and this book falls somewhere in between.
Purpose: The major drawback of encyclopedic texts, especially in the continually evolving HIV arena, is the unavoidable publication delay. This inevitable knowledge gap poses a serious problem for publishers, writers, and readers. Unfortunately, 1996 was a banner year for exciting revelations, not only in the treatment of HIV-AIDS, but for getting off the CD4 dime and moving on to implicating coreceptor(s) for infection. In turn, the latter revelation shed light on genetically dictated resistance to infection. The fact that none of these advances could be adequately addressed in a macrotext revision leads one to question the usefulness of such frequent updating of HIV textbooks. Infectious disease historians might draw a parallel to the syphilis saga at the turn of the century, and one hopes that neurologists will do so with Alzheimer's disease in 2025! After all, most of the clinical fundamentals of HIV-AIDS are now well described and available at multiple levels of reader sophistication. How much more historical and descriptive clinical information could be in the wings? What is needed and now available is rapid access to new HIV understandings by electronic transfer and monthly publications. To the editors' and publisher's credit, an insert detailing the newest strategies of retroviral polytherapy was added, apparently in the terminal stages of publication, but nonetheless, significant scientific discussion on additional subjects ranging from viral load, chemokines, infection resistance, HIV superantigen functions to the depressing evidence that safe sex practices of gay males are being abandoned, the unexpected clash between AIDS activists and animal rights groups, and two straight years of reported AIDS decreases in the U.S. could not be adequately addressed.
Audience: The primary audience for this text is clinicians.
Features: There are many excellent chapters in this book; almost all the clinical and epidemiologic ones are well written. Others, depending on the eyes of the beholder, may have less luster. The book insists on being multidimensional and, in an apparent attempt to mirror the intermingled sociological, political, public health, and psychosocial ramifications of this epidemic, chapters on the latter are scattered throughout. More than a few readers, but certainly not all, will find the placement in the section on psychosocial aspects of the history of community-based responses to HIV-AIDS from the perspective of an activist somewhat curious. The demons of ideology and political correctness, a distraction in many AIDS works, have been almost completely exorcised, but a few vestiges survive. For example, intravenous drug abuse (IVDA) at one point becomes injection of illicit psychoactive drugs (IIPD) and the mantra drumbeat of increasing heterosexual transmission in the U.S. still appears more often than one would expect.
Assessment: This book is recommended to readers who need a fundamental text in HIV biology, transmission, and clinical outcomes. Infectious disease subspecialists and their allies may benefit more from rapid information transfer sources or annual HIV-AIDS reviews.

3 Stars from Doody
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Product Details

  • ISBN-13: 9780397512294
  • Publisher: Lippincott Williams & Wilkins
  • Publication date: 1/1/1992
  • Edition description: REV
  • Edition number: 3
  • Pages: 624

Table of Contents

I Basic considerations
1 Origin of AIDS 3
2 Etiology of AIDS: Biology of Human Retroviruses 13
3 The Molecular Biology of HIV-1 39
4 Immunopathogenesis of HIV Infection 61
5 Immune Responses to HIV Infection 77
II Epidemiology
6 Global Aspects of the HIV Epidemic 89
7 Epidemiology of HIV in the United States 99
8 Transmission of the Human Immunodeficiency Virus 111
III Clinical Manifestations
9 Clinical Spectrum of HIV Disease 123
10 Serologic Tests for Human Immunodeficiency Virus 141
11 Infectious Complications of HIV 157
A Pneumocystis carinii and Other Protozoa 157
B Fungal Infections in Patients with the Acquired Immunodeficiency Syndrome 167
C Tuberculosis and Other Bacterial Infections 180
D Herpesvirus Infection in Individuals With HIV Infection 193
12 Kaposi's Sarcoma and the Acquired Immunodeficiency Syndrome 209
13 Lymphoma and Other Miscellaneous Cancers 225
14 Central and Peripheral Nervous System Complications of HIV-1 Infection and AIDS 237
15 Gastrointestinal Manifestations of HIV Infection and AIDS 259
16 HIV Infection in Children 285
17 Noninfectious Organ-Specific Complications of HIV Infection 313
A Dermatologic Complications 313
B Pulmonary Complications 320
C Renal Complications 334
D Hematologic Complications of HIV Infection 337
18 Psychiatric and Psychosocial Aspects of HIV Infection 347
IV Treatment of the HIV Infection
19 Strategies and Progress in the Development of Antiretroviral Agents 357
20 Antiretroviral Therapy 373
A Azidothymidine and Other Deoxynucleotide Analogues 373
B Interferon-[alpha] in HIV Infection 395
C Soluble CD4, Immunomodulators, Immunotoxins, and Other Approaches to Anti-HIV Therapy 406
21 Therapeutic Approach to the HIV-Seropositive Patient 417
22 Counseling of HIV-Infected Individuals, Their Families, and Their Partners 435
V Prevention and Public Health
23 Prevention of the Sexual Transmission of HIV 443
24 AIDS Among Drug Injectors: The First Decade 453
25 The Safety of Blood and Blood Products 463
26 Perinatal Transmission of HIV 471
27 AIDS Vaccines 479
28 A Human Rights Framework for Evaluating AIDS Policies: Consent, Confidentiality, and Antidiscrimination 489
29 Technical Successes and Social Failures: Approaching the Second Decade of the AIDS Epidemic 497
VI HIV Infection and the Health Care Worker
30 Occupational Risk of HIV Infection in Health Care Workers 505
31 Safety Precautions for the Health Care Worker 517
A General Precautions to Prevent the Transmission of Blood-Borne and Aerosolized Pathogens 517
B Special Considerations for Surgeons 529
C Special Considerations for Dentists 538
D Special Considerations for Emergency Personnel 543
E Postexposure Management of Health Care Workers Occupationally Exposed to HIV 550
F Sterilization, Disinfection, and Environmental Control 556
32 Management of Health Care Workers Infected With HIV or Other Blood-Borne Pathogens 561
Index 573
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