Airway Remodeling

Overview

This landmark volume discusses the characteristics and impact of the remodeling process on airway function and clinical disease expression within the airway in asthma, covering pharmacological therapies and possible future targets relevant to regulating the remodeling process.

Emphasizes the importance of treating underlying airway inflammation and the relevance of structural alterations to the airway wall, including glandular increases, enhanced collagen deposition within the ...

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Overview

This landmark volume discusses the characteristics and impact of the remodeling process on airway function and clinical disease expression within the airway in asthma, covering pharmacological therapies and possible future targets relevant to regulating the remodeling process.

Emphasizes the importance of treating underlying airway inflammation and the relevance of structural alterations to the airway wall, including glandular increases, enhanced collagen deposition within the submucosa, increased vasculature, smooth hypertrophy, and hyperplasias!

Tracing the development and maintenance of bronchial hyperresponsiveness, decline in lung function, and loss of reversibility evident in chronic asthma, Airway Remodeling

  • describes the contribution of inflammatory cells in the development of airway structural changes
  • examines how pharmaceutical agents act and whether existing treatments modify or prevent remodeling in chronically inflamed asthmatic airways
  • considers whether neural pathways initiate as well as contribute to the airway inflammatory cascade that leads to remodeling
  • reviews the action of cytokines and growth factors on ASM signaling
  • outlines novel approaches to regulating smooth muscle growth
  • clarifies whether permanent ventilatory incapacity in asthma is caused by the uncoupling of the airway and the role of the lung parenchyma
  • details high-resolution computerized tomography scan to measure the internal size of the airway at baseline, during challenge, or after bronchodilatation
  • and more!
    Improving lung function and quality of life by reducing the need for emergency care, hospital admissions, and systemic steroid administration, Airway Remodeling is a superb reference for pulmonologists and respiratory system specialists; physiologists; pneumologists; allergists; pharmacologists; molecular, cellular, and lung biologists; and graduate and medical school students in these disciplines.

The book contains black-and-white illustrations.

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Editorial Reviews

Booknews
Discusses the characteristics and the impact of the remodeling process on airway function and clinical disease expression within the airway in asthma, covering pharmacological therapies and possible future targets relevant to regulating the remodeling process. The 16 contributions emphasize the importance of treating underlying airway inflammation and the relevance of structural alterations to the airway wall, including glandular increases, enhanced collagen deposition within the submucosa, increased vasculature, smooth hypertrophy, and hyperplasias. Topics include the use of morphometry to assess remodeling, signaling mechanisms that regulate airway smooth muscle cell function and growth, the bronchial vessels in airway remodeling, the role of the airway nervous systems, and the role of macrophages. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9780585428048
  • Publisher: NetLibrary, Incorporated
  • Publication date: 1/28/2001

Table of Contents

Introduction
Preface
Contributors
1 What Does Airway Remodeling Mean? Its Relevance to Asthma 1
2 How Can We Assess Airway Remodeling Using Imaging? 5
3 The Use of Morphometry to Assess Airway Wall Remodeling in Asthma 27
4 Physiological Consequences of Lung Remodeling in Asthma 45
5 Consequences of Airway Remodeling to the Patient 57
6 Signaling Mechanisms That Regulate Airway Smooth Muscle Cell Function and Growth 79
7 The Bronchial Vessels in Airway Remodeling 113
8 The Extracelluar Matrix of the Airways and Bronchial Asthma 137
9 Role of the Airway Nervous System in Airway Remodeling 147
10 The Influence of Pharmacological Therapy on Airway Remodeling in Asthma 167
11 The Human Eosinophil and Its Role in Airway Remodeling 189
12 Role of Macrophages in Airway Remodeling in Asthma: Future Therapeutic Target 201
13 Airway Smooth Muscle as a Target for Novel Antiasthma Drugs Acting on Airway Wall Remodeling 217
14 Growth Factor-Extracellular Matrix Interactions in Bronchial Tissue in Asthma 245
15 Is There an Animal Model of Airway Remodeling? 261
16 Future Directions in Airway Remodeling 271
Index 291
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