Airway Remodeling

Airway Remodeling

by Peter H. Howarth
     
 

This landmark volume discusses the characteristics and impact of the remodeling process on airway function and clinical disease expression within the airway in asthma, covering pharmacological therapies and possible future targets relevant to regulating the remodeling process.

Emphasizes the importance of treating underlying airway inflammation and the relevance

Overview

This landmark volume discusses the characteristics and impact of the remodeling process on airway function and clinical disease expression within the airway in asthma, covering pharmacological therapies and possible future targets relevant to regulating the remodeling process.

Emphasizes the importance of treating underlying airway inflammation and the relevance of structural alterations to the airway wall, including glandular increases, enhanced collagen deposition within the submucosa, increased vasculature, smooth hypertrophy, and hyperplasias!

Tracing the development and maintenance of bronchial hyperresponsiveness, decline in lung function, and loss of reversibility evident in chronic asthma, Airway Remodeling

  • describes the contribution of inflammatory cells in the development of airway structural changes
  • examines how pharmaceutical agents act and whether existing treatments modify or prevent remodeling in chronically inflamed asthmatic airways
  • considers whether neural pathways initiate as well as contribute to the airway inflammatory cascade that leads to remodeling
  • reviews the action of cytokines and growth factors on ASM signaling
  • outlines novel approaches to regulating smooth muscle growth
  • clarifies whether permanent ventilatory incapacity in asthma is caused by the uncoupling of the airway and the role of the lung parenchyma
  • details high-resolution computerized tomography scan to measure the internal size of the airway at baseline, during challenge, or after bronchodilatation
  • and more!
    Improving lung function and quality of life by reducing the need for emergency care, hospital admissions, and systemic steroid administration, Airway Remodeling is a superb reference for pulmonologists and respiratory system specialists; physiologists; pneumologists; allergists; pharmacologists; molecular, cellular, and lung biologists; and graduate and medical school students in these disciplines.
  • Editorial Reviews

    Booknews
    Discusses the characteristics and the impact of the remodeling process on airway function and clinical disease expression within the airway in asthma, covering pharmacological therapies and possible future targets relevant to regulating the remodeling process. The 16 contributions emphasize the importance of treating underlying airway inflammation and the relevance of structural alterations to the airway wall, including glandular increases, enhanced collagen deposition within the submucosa, increased vasculature, smooth hypertrophy, and hyperplasias. Topics include the use of morphometry to assess remodeling, signaling mechanisms that regulate airway smooth muscle cell function and growth, the bronchial vessels in airway remodeling, the role of the airway nervous systems, and the role of macrophages. Annotation c. Book News, Inc., Portland, OR (booknews.com)

    Product Details

    ISBN-13:
    9780824704483
    Publisher:
    Taylor & Francis
    Publication date:
    01/28/2001
    Series:
    Lung Biology in Health and Disease Series
    Edition description:
    New Edition
    Pages:
    328
    Product dimensions:
    6.25(w) x 9.25(h) x 1.00(d)

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