Airways Smooth Muscle: Modelling the Asthmatic Response In Vivo

Overview

Building on the existing titles in the "Airways Smooth Muscle" sub-series, the sixth volume explores physiological and pharmacological processes in the lung in vivo. The various animal models available for studying the bronchospasm and inflammation associated with human asthma are thoroughly reviewed by internationally recognised scientists. Specific chapters focus on the problems of administering drugs to animal airways, the mechanics of assessing lung function in the models, and describe in detail the species ...

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Overview

Building on the existing titles in the "Airways Smooth Muscle" sub-series, the sixth volume explores physiological and pharmacological processes in the lung in vivo. The various animal models available for studying the bronchospasm and inflammation associated with human asthma are thoroughly reviewed by internationally recognised scientists. Specific chapters focus on the problems of administering drugs to animal airways, the mechanics of assessing lung function in the models, and describe in detail the species used, from rodents to primates. The use of genetically altered animals, an area of particular interest to molecular biologists, is also considered in depth. This up-to-date and extensively referenced work will prove invaluable to pharmacologists, physiologists and other biological scientists at all levels in academia and in the pharmaceutical industry.

Antigen-induced bronchial hyperreactivity in rats/primate models of asthma/transgenic animals & the modeling of asthma

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Editorial Reviews

Booknews
For researchers using animals to investigate human asthma, explains physiological and pharmacological process in the lung in vivo, and reviews the animal models available for studying the bronchospasm and inflammation associated with human asthma. Also discusses such methodological aspects as administering drugs to animal airways and the mechanics of assessing lung function. Also considers the use of genetically altered animals as research models. The sixth volume in the Airways Smooth Muscle sub- series. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

Table of Contents

List of Contributors
1 Measurement of Airways Smooth Muscle Responsiveness in Animals 1
2 Methods of Drug Administration to the Lung in Animals 27
3 PAF and Antigen-Induced Bronchial Hyperreactivity in Guinea Pigs 51
4 Antigen-Induced Bronchial Hyperreactivity in Rats 75
5 Ozone-Induced Bronchial Hyperreactivity 95
6 Virus-Induced Bronchial Hyperreactivity 121
7 The Rabbit Model of Asthma and the Late Asthmatic Response 147
8 The Sheep as a Model of the Late Asthmatic Response 171
9 Primate Models of Asthma 191
10 The Sensitized Pig Model of Asthma 225
11 Transgenic Animals and the Modelling of Asthma 241
Index 275
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