Alcohol, Drugs and Medication in Pregnancy: The Long Term Outcome for the Child / Edition 1

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Overview

Clinics in Developmental Medicine No. 188

This book documents the consequences of the exposure of infantsto the influence of intrauterine chemicals. In setting out theevidence for these outcomes, the authors demonstrate that decisionsabout care and management can and should be made as early aspossible. This should allow professionals to provide protectivemanagement and prevent the delays that are so often seen in thisarea of medical and social care.

The international team of contributors sets out to inform thereader of the potential risks to infants exposed to a range ofintrauterine chemicals that are potentially neuroactive, includingmedicinal drugs such as antiepileptics, antidepressants andantipsychotics, as well as drugs of abuse, including alcohol,opiates, and recreational drugs such as cannabis and tobacco. Theyreview the teratogenic action of some of the chemical processes andthe relationship of exposure to the stage of pregnancy. Some agentsalter anatomic structure; others alter the chemical balance ofneurotransmitters and may thus alter the regulation of brainfunction, with profound effects on the child's behaviour andpropensity to behavioural disturbances. The book exploresstrategies to support these children and those who care for them,including statutory agencies.

Readership
Paediatricians, neonatologists, obstetricians, gynaecologists,child and adolescent psychiatrists and psychologists, those workingin child care and child protection.

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Editorial Reviews

Doody's Review Service
Reviewer: Anthony Shanks, MD (Washington University School of Medicine)
Description: This book examines the fetal and postnatal effects of a variety of substances taken by pregnant mothers.
Purpose: It attempts to provide a comprehensive overview of medications and substances that are taken by the pregnant mother and the effects on her child. Certainly, this is a worthwhile objective and the authors do a nice job of describing the information and addressing some substances that are not commonly evaluated.
Audience: The book is intended for healthcare providers to pregnant women who use these medications or substances. Therefore, it is not restricted to obstetricians/gynecologists — psychiatrists, neurologists, and family practitioners all may find the book interesting.
Features: The title may be a problem. When I first saw it, I immediately thought it would be another desk reference that lists medications in bulleted format and their corresponding complications. However, when I opened it, my first reaction was that it was too wordy and would not replace my other books for this purpose (e.g. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, 9th edition, Briggs (Lippincott Williams & Wilkins, 2011)). Once I started reading, I found much of interest. The chapters on alcohol, cocaine, marijuana, and methamphetamine are quite novel and perhaps the most complete review of this literature in a book. I would encourage the authors to highlight this aspect of the book. The other chapters are comprehensive and do a good job of incorporating the currently available evidence. Chapter 4 is a nice review of seizure disorder in pregnancy, but I would have liked an explanation for why they chose 5 mg of folic acid (as opposed to 4 mg) and I would have liked an exploration of the use of vitamin K in the third trimester to prevent potential hemorrhage. (Not that I necessarily agree with either of those points, but it would be worthwhile to discuss it.) Chapter 10 on in utero exposure to recreational drugs was interesting. The American College of Obstetricians and Gynecologists recently released a committee opinion, in March 2011, on the subject and it would be helpful to include a mention of this in the conclusion of the chapter, but I realize that the book may have already been in production.
Assessment: This book tackles a common problem from a slightly different angle. It is comprehensive and not designed for quick and easy reference. The chapters on recreational drugs are standouts. I would have liked to have more color in the pictures, but overall it is an aesthetically pleasing textbook and a nice addition to the literature.
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Product Details

  • ISBN-13: 9781898683889
  • Publisher: Wiley
  • Publication date: 3/15/2011
  • Series: Clinics in Developmental Medicine Series , #188
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 256
  • Product dimensions: 6.90 (w) x 9.50 (h) x 0.90 (d)

Meet the Author

Philip Preece is a consultant paediatrician with training inneurodisability. He manages a range of children with autismspectrum disorders, attention-deficit hyperactivity disorder, andlearning difficulties. He has developed an interest in the outcomeof infants exposed to prenatal drugs, both medicinal andrecreational, as part of his work assessing children prior toadoption.

Ed Riley served as Chair of the National Task Force onFetal Alcohol Syndrome/Fetal Alcohol Effect. He currently serves asthe Steering Committee Co-Chair of the Fetal Alcohol SpectrumDisorders Center for Excellence. He has been President of theResearch Society on Alcohol, the Fetal Alcohol Study Group, and theBehavioral Teratology Society. He has served as Associate Editor ofthe Journal of Studies on Alcohol, and is on the EditorialBoards of Alcoholism: Clinical and Experimental Research andthe Psychological Record. He has received numerous awardsfor his scholarship and service, most recently the Research Societyon Alcoholism Distinguished Researcher Award.

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Table of Contents

AUTHORS' APPOINTMENTS vii

1. INTRODUCTION 1
Philip M Preece

SECTION 1. NEUROTERATOGENESIS – EPIDEMIOLOGY ANDPATHOLOGY

2. EPIDEMIOLOGY OF DRUG AND ALCOHOL USE DURING PREGNANCY11
Ron Gray

3. NORMAL AND ABNORMAL EMBRYOGENESIS OF THE MAMMALIAN BRAIN23
Kathy K Sulik, Shonagh K O'Leary-Moore, Elizabeth A Godin andScott E Parnell

SECTION 2. LONG-TERM EFFECTS OF MAJOR PRESCRIBEDMEDICATIONS

4. EPILEPSY IN PREGNANCY AND THE EFFECT OF PRENATALANTIEPILEPTIC MEDICATION 44
Jill Clayton-Smith and Gus Baker

5. NEURODEVELOPMENT OF CHILDREN EXPOSED TO ANTIDEPRESSANT ANDANTIPSYCHOTIC MEDICATIONS DURING PREGNANCY 56
Irene Nulman, Sara Citron, Michelle Todorow and ElizabethUleryk

SECTION 3. LONG-TERM EFFECTS OF DRUGS OF ABUSE

6. DIAGNOSIS OF FETAL ALCOHOL SYNDROME: EMPHASIS ON EARLYDETECTION 85
Margaret Barrow and Edward P Riley

7. THE EFFECTS OF PRENATAL ALCOHOL EXPOSURE ON BRAIN ANDBEHAVIOUR 108
Christie L McGee Petrenko and Edward P Riley

8. EFFECT OF DRUGS OF ABUSE ON THE FETUS: COCAINE AND OPIATESINCLUDING HEROIN 130
Lynn T Singer and Sonia Minnes

9. CANNABIS USE DURING PREGNANCY: ITS EFFECTS ON OFFSPRING FROMBIRTH TO YOUNG ADULTHOOD 153
Peter A Fried

10. IN UTERO EXPOSURE TO THE POPULAR 'RECREATIONAL' DRUGS MDMA(ECSTASY) AND METHAMPHETAMINE (ICE, CRYSTAL): PRELIMINARY FINDINGS169
Derek G Moore, John J D Turner, Julia E Goodwin, Sarah E Fulton,Lynn T Singer and Andrew C Parrott

11. THE SHORT-TERM AND LONG-TERM DEVELOPMENTAL CONSEQUENCES OFMATERNAL SMOKING DURING PREGNANCY 183
Kate E Pickett and Lauren S Wakschlag

SECTION 4. INTERVENTION STRATEGIES TO REDUCE THE IMPACT OFDRUGS AND ALCOHOL IN PREGNANCY

12. MANAGEMENT OF THE EFFECTS OF PRENATAL DRUGS IN CHILDREN OFDRUG-ABUSING PARENTS 197
Faye Macrory and Michael Murphy

13. PRENATAL AND POSTNATAL INTERVENTION STRATEGIES FORALCOHOL-ABUSING MOTHERS IN PREGNANCY 217
Ann P Streissguth and Therese M Grant

14. COGNITIVE AND BEHAVIOURAL INTERVENTIONS TO AMELIORATE THEEFFECTS OF FETAL ALCOHOL SPECTRUM DISORDERS IN CHILDREN ANDADOLESCENTS: PROMOTING POSITIVE OUTCOMES 234
Wendy O Kalberg and Julie Gelo

15. FETAL TERATOGEN SYNDROMES: PSYCHIATRIC ASPECTS ANDMANAGEMENT 252
David J Bramble and Raja A S Mukherjee

16. RECOMMENDED MANAGEMENT OF COMMON MEDICAL PROBLEMS INPREGNANCY: ADVICE FROM SPECIALIST AGENCIES 271
Evelyne Jacqz-Aigrain and Philip M Preece

INDEX 280

COLOUR PLATE SECTION

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