The Alkaloids: Chemistry and Biology

The Alkaloids: Chemistry and Biology

by Geoffrey A. Cordell
     
 

This series is world-renowned as the leading compilation of current reviews of this vast field. Internationally acclaimed for more than 40 years, The Alkaloids: Chemistry and Biology, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of this rapidly expanding field. Each volume provides, through its distinguished authors, up

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Overview

This series is world-renowned as the leading compilation of current reviews of this vast field. Internationally acclaimed for more than 40 years, The Alkaloids: Chemistry and Biology, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of this rapidly expanding field. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids.

* Comprehensive, up-to-date reviews

* Contributions from leading authors in their respective fields

* Broad coverage of the chemical and biological aspects of important natural products

Product Details

ISBN-13:
9780123747853
Publisher:
Elsevier Science
Publication date:
10/15/2009
Series:
Alkaloids Series
Pages:
296
Product dimensions:
6.20(w) x 9.10(h) x 0.90(d)

Table of Contents

Contributors
Preface
Clinical Studies of Camptothecin and Derivatives
Mechanisms of Action3
Mutagenicity and Resistance Mechanisms7
Irinotecan9
Topotecan19
Considerations of Route of Administration27
Investigational Derivatives29
Tremorgenic and Nontremorgenic 2,3-Fused Indole Diterpenoids
Isolation53
Synthesis125
Biosynthesis144
Structure and Tremorgenicity155
The Daphniphyllum Alkaloids
Structures of Representative Alkaloids170
Biosynthesis and Biogenesis184
Synthesis193
The Manzamine Alkaloids
Isolation and Structure Elucidation from Marine Sponges214
Biogenesis and Biosynthesis223
Synthesis264
Pharmacology270
Sesquiterpene Pyridine Alkaloids
Evoninate Sesquiterpene Pyridine Alkaloids and Derivatives289
Wilfordate Sesquiterpene Pyridine Alkaloids and Derivatives307
Edulinate Sesquiterpene Pyridine Alkaloids315
Cassinate Sesquiterpene Pyridine Alkaloids317
Lower Molecular Weight Sesquiterpene Pyridine Alkaloids317
Non-Celastraceous Sesquiterpene Pyridine Alkaloids318
Biosynthesis and Biogenesis322
Biological Activity330
Taxonomic Considerations334
Synthesis334
Chemical and Biological Aspects of Melanin
Biogenesis of Melanin347
Natural Melanins354
Investigations of Melanins by Physical Methods373
Synthetic Melanins376
Physicochemical Properties and Biological Functions of Melanins379
Index393

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