The Alkaloids: Chemistry and Biology

The Alkaloids: Chemistry and Biology

by Geoffrey A. Cordell
     
 

ISBN-10: 012373911X

ISBN-13: 9780123739117

Pub. Date: 12/11/2007

Publisher: Elsevier Science

Internationally acclaimed for more than 40 years, The Alkaloids,/B>, founded by the late Professor R. H. F. Manske, continues to provide outstanding coverage of the rapidly expanding field of the chemotaxonomy, structure elucidation, synthesis, biosynthesis, and biology of all classes of alkaloids from higher and lower plants, marine organisms, or various terrestrial…  See more details below

Overview

Internationally acclaimed for more than 40 years, The Alkaloids,/B>, founded by the late Professor R. H. F. Manske, continues to provide outstanding coverage of the rapidly expanding field of the chemotaxonomy, structure elucidation, synthesis, biosynthesis, and biology of all classes of alkaloids from higher and lower plants, marine organisms, or various terrestrial animals. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids.

Over the years, this series has become the standard in natural product chemistry to which all other book series aspire. The Alkaloids: Chemistry and Biology endures as an essential reference for all natural product chemists and biologists who have an interest in alkaloids, their diversity, and their unique biological profile.

Product Details

ISBN-13:
9780123739117
Publisher:
Elsevier Science
Publication date:
12/11/2007
Series:
Alkaloids Series
Pages:
248
Product dimensions:
9.21(w) x 6.14(h) x 0.63(d)

Table of Contents

Contributors
Preface
Clinical Studies of Camptothecin and Derivatives
Mechanisms of Action3
Mutagenicity and Resistance Mechanisms7
Irinotecan9
Topotecan19
Considerations of Route of Administration27
Investigational Derivatives29
Tremorgenic and Nontremorgenic 2,3-Fused Indole Diterpenoids
Isolation53
Synthesis125
Biosynthesis144
Structure and Tremorgenicity155
The Daphniphyllum Alkaloids
Structures of Representative Alkaloids170
Biosynthesis and Biogenesis184
Synthesis193
The Manzamine Alkaloids
Isolation and Structure Elucidation from Marine Sponges214
Biogenesis and Biosynthesis223
Synthesis264
Pharmacology270
Sesquiterpene Pyridine Alkaloids
Evoninate Sesquiterpene Pyridine Alkaloids and Derivatives289
Wilfordate Sesquiterpene Pyridine Alkaloids and Derivatives307
Edulinate Sesquiterpene Pyridine Alkaloids315
Cassinate Sesquiterpene Pyridine Alkaloids317
Lower Molecular Weight Sesquiterpene Pyridine Alkaloids317
Non-Celastraceous Sesquiterpene Pyridine Alkaloids318
Biosynthesis and Biogenesis322
Biological Activity330
Taxonomic Considerations334
Synthesis334
Chemical and Biological Aspects of Melanin
Biogenesis of Melanin347
Natural Melanins354
Investigations of Melanins by Physical Methods373
Synthetic Melanins376
Physicochemical Properties and Biological Functions of Melanins379
Index393

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