The Alkaloids: Chemistry and Biology

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Overview

Internationally acclaimed for more than 40 years, The Alkaloids,/B>, founded by the late Professor R. H. F. Manske, continues to provide outstanding coverage of the rapidly expanding field of the chemotaxonomy, structure elucidation, synthesis, biosynthesis, and biology of all classes of alkaloids from higher and lower plants, marine organisms, or various terrestrial animals. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids.

Over the years, this series has become the standard in natural product chemistry to which all other book series aspire. The Alkaloids: Chemistry and Biology endures as an essential reference for all natural product chemists and biologists who have an interest in alkaloids, their diversity, and their unique biological profile.

Audience: For chemists, pharmacologists, and biochemists.

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Product Details

  • ISBN-13: 9780123739117
  • Publisher: Elsevier Science
  • Publication date: 12/11/2007
  • Series: The Alkaloids Series
  • Pages: 248
  • Product dimensions: 9.21 (w) x 6.14 (h) x 0.63 (d)

Meet the Author

Professor Emeritus Geoffrey A. Cordell obtained his Ph.D. in synthetic natural product chemistry at the University of Manchester in 1970. After two years as a NATO postdoctoral fellow at the Department of Chemistry, M.I.T., he joined the College of Pharmacy, University of Illinois at Chicago (UIC). A Professor since 1980, he served as a Department Head for 12 years and as Interim Dean of the College of Pharmacy for almost three years, as well as holding several other senior academic and research administrative positions at the Department, College, and Campus levels. He was the Co-founder of the US - Thai Consortium for Pharmacy Education, which developed and trained faculty for six new schools of pharmacy in Thailand. He retired from the University of Illinois in 2007. Since 1983, he has served as President of Natural Products Inc., a consulting company.
He is the author of about 600 research publications, book chapters, comprehensive reviews and professional publications; is the author of two books, with three more in progress; the editor of 37 books, including 29 volumes in the series “The Alkaloids: Chemistry and Biology”; is Associate Editor-in-Chief of the Chinese Journal of Natural Medicines; and a member of the Editorial Advisory Board of 26 international scientific journals. He is a former President of the American Society of Pharmacognosy, and is also an Honorary Member.
In 1981, he was an Alexander von Humboldt Fellow at the University of Munich with Professor Hildebert Wagner. He is an elected Fellow of the Royal Chemical Society, the Linnean Society of London, the American Society of Pharmacognosy, and the American Association of Pharmaceutical Scientists. In addition to assisting international organizations and corporations in several countries around the world to develop their research and academic programs, he is an Honorary Professor at Sichuan University, Chengdu, China; and at Amity University, Noida, India. He is also a Visiting Professor at universities in Peru, Malaysia, and Brasil, and an International Collaborative Partner of the UTAR Global Research Network in Malaysia in the areas of biodiversity and cancer. In addition, he is a member of the International Advisory Board of several natural product research institutes. His interests include the chemistry and biosynthesis of alkaloids, the sustainability and quality control of medicinal agents, the remote detection of biologically active natural products, and the use of vegetables as chemical reagents.
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Table of Contents

Contributors
Preface
Clinical Studies of Camptothecin and Derivatives
Mechanisms of Action 3
Mutagenicity and Resistance Mechanisms 7
Irinotecan 9
Topotecan 19
Considerations of Route of Administration 27
Investigational Derivatives 29
Tremorgenic and Nontremorgenic 2,3-Fused Indole Diterpenoids
Isolation 53
Synthesis 125
Biosynthesis 144
Structure and Tremorgenicity 155
The Daphniphyllum Alkaloids
Structures of Representative Alkaloids 170
Biosynthesis and Biogenesis 184
Synthesis 193
The Manzamine Alkaloids
Isolation and Structure Elucidation from Marine Sponges 214
Biogenesis and Biosynthesis 223
Synthesis 264
Pharmacology 270
Sesquiterpene Pyridine Alkaloids
Evoninate Sesquiterpene Pyridine Alkaloids and Derivatives 289
Wilfordate Sesquiterpene Pyridine Alkaloids and Derivatives 307
Edulinate Sesquiterpene Pyridine Alkaloids 315
Cassinate Sesquiterpene Pyridine Alkaloids 317
Lower Molecular Weight Sesquiterpene Pyridine Alkaloids 317
Non-Celastraceous Sesquiterpene Pyridine Alkaloids 318
Biosynthesis and Biogenesis 322
Biological Activity 330
Taxonomic Considerations 334
Synthesis 334
Chemical and Biological Aspects of Melanin
Biogenesis of Melanin 347
Natural Melanins 354
Investigations of Melanins by Physical Methods 373
Synthetic Melanins 376
Physicochemical Properties and Biological Functions of Melanins 379
Index 393
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