The Alkaloids: Chemistry and Biology

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Overview

Internationally acclaimed for more than 40 years, The Alkaloids,/B>, founded by the late Professor R. H. F. Manske, continues to provide outstanding coverage of the rapidly expanding field of the chemotaxonomy, structure elucidation, synthesis, biosynthesis, and biology of all classes of alkaloids from higher and lower plants, marine organisms, or various terrestrial animals. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids.

Over the years, this series has become the standard in natural product chemistry to which all other book series aspire. The Alkaloids: Chemistry and Biology endures as an essential reference for all natural product chemists and biologists who have an interest in alkaloids, their diversity, and their unique biological profile.

Audience: For chemists, pharmacologists, and biochemists.

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Product Details

  • ISBN-13: 9780123739117
  • Publisher: Elsevier Science
  • Publication date: 12/11/2007
  • Series: The Alkaloids Series
  • Pages: 248
  • Product dimensions: 9.21 (w) x 6.14 (h) x 0.63 (d)

Table of Contents

Contributors
Preface
Clinical Studies of Camptothecin and Derivatives
Mechanisms of Action 3
Mutagenicity and Resistance Mechanisms 7
Irinotecan 9
Topotecan 19
Considerations of Route of Administration 27
Investigational Derivatives 29
Tremorgenic and Nontremorgenic 2,3-Fused Indole Diterpenoids
Isolation 53
Synthesis 125
Biosynthesis 144
Structure and Tremorgenicity 155
The Daphniphyllum Alkaloids
Structures of Representative Alkaloids 170
Biosynthesis and Biogenesis 184
Synthesis 193
The Manzamine Alkaloids
Isolation and Structure Elucidation from Marine Sponges 214
Biogenesis and Biosynthesis 223
Synthesis 264
Pharmacology 270
Sesquiterpene Pyridine Alkaloids
Evoninate Sesquiterpene Pyridine Alkaloids and Derivatives 289
Wilfordate Sesquiterpene Pyridine Alkaloids and Derivatives 307
Edulinate Sesquiterpene Pyridine Alkaloids 315
Cassinate Sesquiterpene Pyridine Alkaloids 317
Lower Molecular Weight Sesquiterpene Pyridine Alkaloids 317
Non-Celastraceous Sesquiterpene Pyridine Alkaloids 318
Biosynthesis and Biogenesis 322
Biological Activity 330
Taxonomic Considerations 334
Synthesis 334
Chemical and Biological Aspects of Melanin
Biogenesis of Melanin 347
Natural Melanins 354
Investigations of Melanins by Physical Methods 373
Synthetic Melanins 376
Physicochemical Properties and Biological Functions of Melanins 379
Index 393
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