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Allostasis, Homeostasis, and the Costs of Physiological Adaptation

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Overview

The concept of homeostasis, the maintenance of the internal physiological environment of an organism within tolerable limits, is well established in medicine and physiology. In contrast, allostasis is a relatively new idea of 'viability through change'. With allostatic regulation by cephalic involvement, the body adapts to potentially diverse and dangerous situations through the activation of neural, hormonal, or immunological mechanisms. Allostasis explains how regulatory events maintain organismic viability, or not, in diverse contexts with varying set points of bodily needs and competing motivations. This book introduces the concept of allostasis and sets it alongside traditional views of homeostasis. It addresses basic regulatory systems and examines the behavior of bodily regulation under duress. The basic concepts of physiological homeostasis are integrated with disorders like depression, stress, anxiety and addiction. It will therefore appeal to graduate students, medical students and researchers working in physiology, epidemiology, endocrinology, neuroendocrinology, neuroscience, and psychology.

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Editorial Reviews

From the Publisher
Review of the hardback: 'This book … is very welcome as it goes a good way towards introducing readers of all levels to the concept … it is well balanced … this book will be an important text for those who want to know more.' Biologist
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Product Details

  • ISBN-13: 9780521811415
  • Publisher: Cambridge University Press
  • Publication date: 9/28/2004
  • Pages: 384
  • Product dimensions: 6.97 (w) x 9.96 (h) x 1.10 (d)

Table of Contents

Introduction 1
1 Principles of allostasis : optimal design, predictive regulation, pathophysiology, and rational therapeutics 17
2 Protective and damaging effects of the mediators of stress and adaptation : allostasis and allostatic load 65
3 Merging of the homeostat theory with the concept of allostatic load 99
4 Operationalizing allostatic load 113
5 Drug addiction and allostasis 150
6 Adaptive fear, allostasis, and the pathology of anxiety and depression 164
7 A chronobiological perspective on allostasis and its application to shift work 228
8 Allostatic load and life cycles : implications for neuroendocrine control mechanisms 302
Commentary : viability as opposed to stability : an evolutionary perspective on physiological regulation 343
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