An introduction to genetic epidemiology / Edition 1

by Lyle J. Palmer, Paul R. Burton, George Davey Smith

Overview

Genetic epidemiology is a very rapidly developing field that has acquired a central role in modern biomedical science. Until now there has been no comprehensive introductory text for students and academics who do not have specialised training in statistics or genetics.

This book begins with a primer in human molecular genetics and then examines standard methods in population genetics and genetic epidemiology required for an adequate grounding in the field. Among much else, the book contains discussion of the public health aspects of the new genetics, and of epidemiological methods for studying genes and environmental factors in complex diseases.

Written by leading international experts and supplemented by a glossary and in-chapter guides to further reading, this essential textbook will be widely welcomed by teachers and students on many courses internationally.

Product Details

ISBN-13:	9781861348975
Publisher:	Bristol University Press
Publication date:	05/31/2011
Series:	Health and Society
Edition description:	First Edition
Pages:	256
Product dimensions:	6.70(w) x 9.40(h) x 0.60(d)

About the Author

Lyle J. Palmer is Professor of Biostatistics and Epidemiology at the University of Toronto, Canada.

Paul R Burton is Professor of Genetic Epidemiology at the University of Leicester, UK.

George Davey Smith is Professor of Clinical Epidemiology at the University of Bristol, UK.

Table of Contents

List of tables, figures and boxes

Notes on contributors

Acknowledgements

Introduction Lyle J. Palmer Paul R. Burton George Davey Smith 1

one Key concepts in genetic epidemiology Paul R. Burton Martin D.Tobin John L Hopper 5

2 Genetic linkage studies M. Dawn Teare Jennifer H. Barrett 39

3 Genetic association studies Heather J. Cordell David G. Clayton 61

4 Mapping complex disease genes using linkage disequilibrium and genome-wide association scans Lyle J. Palmer Nicholas J. Timpson David M. Evans George Davey Smith Lon R. Cordon 91

5 A question of standards: what makes a good genetic association study? Andrew T. Hattersley Mark I. McCarthy 131

6 Biobanks and biobank harmonisation Paul R. Burton Isabel Fortier Mylene Deschênes Anna Hansell Lyle J. Palmer 155

7 Population health aspects of genetic epidemiology: genomic profiling, personalised medicine, and Mendelian randomisation George Davey Smith Shah Ebrahim Sarah Lewis Lyle J. Palmer 175

Glossary 217

Index 225

What People are Saying About This

From the Publisher

"This is a sobering must-read for anyone who wishes to know how genetic epidemiology may change how we understand, treat or prevent human disease." Robert Elston, Case Western Reserve UniversitySchool of Medicine

"This book should be incredibly useful to students and researchers at all levels in genetic epidemiology. For students it offers an eminently readable and accessible foundation, and for researchers, a superb source to fill in missing pieces in our knowledge." Ezra Susser, Professor of Epidemiology and Psychiatry, Mailman School of Public Health, Columbia University, and New York State Psychiatric Institute

Editorial Reviews

"This is a sobering must-read for anyone who wishes to know how genetic epidemiology may change how we understand, treat or prevent human disease." Robert Elston, Case Western Reserve UniversitySchool of Medicine

"This book should be incredibly useful to students and researchers at all levels in genetic epidemiology. For students it offers an eminently readable and accessible foundation, and for researchers, a superb source to fill in missing pieces in our knowledge." Ezra Susser, Professor of Epidemiology and Psychiatry, Mailman School of Public Health, Columbia University, and New York State Psychiatric Institute

From the Publisher