Anaerobic Parasitic Protozoa: Genomics and Molecular Biology

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Overview

Anaerobic parasitic protozoa cause medically and economically important diseases - such as dysentery, sexually transmitted infections, and gastroenteritis - that annually affect millions of people worldwide. Recently, the genomes of the three key anaerobic protozoa - Trichomonas, Giardia, and Entamoeba - have been determined. The availability of these genomic data and the use of post-genomic analyses have provided fascinating new insights into the biology of these important parasites. They will be important for the design of novel anti-protozoan drugs and the development of effective vaccines. In this book, internationally acclaimed researchers critically review the most important aspects of research on anaerobic parasitic protozoa, providing the first coherent picture of their genomics and molecular biology since the publication of the genomes. Chapters are written from a molecular and genomic perspective and contain speculative models upon which future research efforts can be based. Topics include: the genomes of Entamoeba histolytica, Trichomonas vaginalis, Giardia, and other diplomonads; the cytoskeletons of Entamoeba histolytica, Giardia lamblia, and Trichomonas vaginalis; genomic analyses and manipulation of gene expression in Entamoeba histolytica; nuclear and chromosomal structure and replication in Giardia; and the mitochondrion-like organelles of a fourth anaerobe, Blastocystis. The book is essential reading for all researchers working with these protozoa and related organisms and with eukaryotic model organisms. It is recommended for all parasitology laboratories.
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Product Details

  • ISBN-13: 9781904455615
  • Publisher: Caister Academic Press
  • Publication date: 3/1/2010
  • Pages: 232
  • Product dimensions: 7.00 (w) x 10.00 (h) x 0.80 (d)

Table of Contents

1 Entamoeba histolytica : genome status and Web resources Elisabet Caler Caler, Elisabet Herman Lorenzi Lorenzi, Herman 1

2 The genome of Giardia and other diplomonads Jan O. Andersson Andersson, Jan O. Jon Jeristrom-Hultqvist Jeristrom-Hultqvist, Jon Staffan G. Svard Svard, Staffan G. 23

3 The genome of Trichomonas vaginalis Jane M. Carlton Carlton, Jane M. Shehre-Banoo Malik Malik, Shehre-Banoo Steven A. Sullivan Sullivan, Steven A. Thomas Sichertz-Ponten Sichertz-Ponten, Thomas Petrus Tang Tang, Petrus Robert P. Hirt Hirt, Robert P. 45

4 Dissecting the actin cytoskeleton of Entamoeba histolytica from a genomic perspective Chung Chau Hon Chung, Chau Hon Kumko Nakada-Tsukui Nakada-Tsukui, Kumko Tomoyoshi Nozaki Nozaki, Tomoyoshi Nancy Guillen Guillen, Nancy 81

5 New insights into the composition and function of the cytoskeleton in Giardia lamblia and Trichomonas vaginalis Heidi G. Elmendorf Elmendorf, Heidi G. Richard D. Hayes Hayes, Richard D. Shweta Srivastava Srivastava, Shweta Patricia J. Johnson Johnson, Patricia J. 119

6 Entamoeba histolytica genomic analyses Upinder Singh Singh, Upinder Gretchen M. Ehrenkaufer Ehrenkaufer, Gretchen M. 157

7 Manipulation of gene expression in Entamoeba histolytica Rivka Bracha Bracha, Rivka Nancy Guillen Guillen, Nancy David Mirelman Mirelman, David 175

8 Giardia : nuclear and chromosomal structure and replication Rodney D. Adam Adam, Rodney D. Staffan G. Svard Svard, Staffan G. 193

9 The Blastocystis mitochondrion-like organelles Anastasios D. Tsaousis Tsaousis, Anastasios D. Alexandra Stechmann Stechmann, Alexandra Karleigh A. Hamblin Hamblin, Karleigh A. Mark van der Giezen van der Giezen, Mark Vicente Perez-Brocal Perez-Brocal, Vicente C. Graham Clark Clark, C. Graham 205

Index 221

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