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More About This Textbook
Overview
The first and still the only book of its kind, this volume offers a concise introduction to human genetic linkage analysis and gene mapping. Jurg Ott provides mathematical and statistical foundations of linkage analysis for researchers and practitioners, as well as practical comments on available computer programs and websites. Each chapter ends with a set of problems, whose solutions are found at the end of the book.
New to this edition is a chapter on complex traits, such as diabetes, some cancers, and psychiatric conditions. Also new is an overview of nonparametric approaches to linkage and association analysis. A chapter on two-locus inheritance introduces the reader to many of the intricate aspects of complex traits. Although the book's primary audience is in the field of genetics, physicians and others without sophisticated training in genetics can understand and apply the principles and techniques discussed.
The Johns Hopkins University Press
The book contains black-and-white illustrations.
The first and still the only one of its kind, this book offers a concise introduction to human genetic linkage analysis and gene mapping. Jurg Ott provides mathematical and statistical foundations of linkage analysis for researchers and practitioners, as well as practical comments on available computer programs and websites.
Editorial Reviews
Biometrics
For the last decade this book has been the unrivaled standard text on human genetic linkage analysis.— J.H. Barrett
Biotech Software and Internet Report
One of the best books that cover the theory behind linkage analysis. Scientists with an interest in genetic linkage analysis should definitely consider allocating space on their bookshelves for this book.
<I>American Journal of Human Genetics</I>
Overall the book achieves an excellent compromise between presenting important conclusions and working out the details... Analysis of Human Genetic Linkage is a good book that has been made substantially better. It continues to be the standard reference for every linkage analyst's library and to provide an excellent introduction for the interested beginner with a background in the biological or mathematical sciences.
American Journal of Human Genetics
Overall the book achieves an excellent compromise between presenting important conclusions and working out the details... Analysis of Human Genetic Linkage is a good book that has been made substantially better. It continues to be the standard reference for every linkage analyst's library and to provide an excellent introduction for the interested beginner with a background in the biological or mathematical sciences.
Biometrics - J.H. Barrett
For the last decade this book has been the unrivaled standard text on human genetic linkage analysis.
Michael Cummings
In every profession there are a few essential books found on the shelves of everyone working in the field. In human genetics, this book is one of those indispensable reference works. The last edition, published some eight years ago, was outdated in many respects. As in past editions, the emphasis is on teaching the reader how to carry out linkage analysis without the use advanced statistical methods. The result is an elegant, well-crafted book from which readers quickly grasp the basic methods of linkage analysis and learn to appreciate its nuances and potential problems. Students, researchers, counselors, and clinicians in all areas of human genetics should welcome this new edition, which is extensively revised, updated, and expanded. Basic Mendelian genetics are introduced in first two chapters. These chapters include sections on DNA polymorphisms and their use in constructing genetic and physical maps. The chapter on statistics has been reworked and continues to be a model of clear writing integrated with simple mathematical applications. The heart of the book is Chapters 4-8, in which the editor lays out the methods used in linkage analysis in human genetics. In the next six chapters he introduces software programs used in linkage analysis, and factors that affect the results of such analysis. A new chapter contains a survey of methods currently used in studying complex traits, including sampling and analysis strategies. This new edition is a valuable resource. It is the most accessible work on the subject, and should be in the collection of everyone interested in mapping human genes.From The Critics
Reviewer:Michael Cummings, PhD (University of Illinois at Chicago)Description:In every profession there are a few essential books found on the shelves of everyone working in the field. In human genetics, this book is one of those indispensable reference works. The last edition, published some eight years ago, was outdated in many respects.
Purpose:As in past editions, the emphasis is on teaching the reader how to carry out linkage analysis without the use advanced statistical methods. The result is an elegant, well-crafted book from which readers quickly grasp the basic methods of linkage analysis and learn to appreciate its nuances and potential problems.
Audience:Students, researchers, counselors, and clinicians in all areas of human genetics should welcome this new edition, which is extensively revised, updated, and expanded.
Features:Basic Mendelian genetics are introduced in first two chapters. These chapters include sections on DNA polymorphisms and their use in constructing genetic and physical maps. The chapter on statistics has been reworked and continues to be a model of clear writing integrated with simple mathematical applications. The heart of the book is Chapters 4-8, in which the editor lays out the methods used in linkage analysis in human genetics. In the next six chapters he introduces software programs used in linkage analysis, and factors that affect the results of such analysis. A new chapter contains a survey of methods currently used in studying complex traits, including sampling and analysis strategies.
Assessment:This new edition is a valuable resource. It is the most accessiblework on the subject, and should be in the collection of everyone interested in mapping human genes.
Booknews
An introduction to linkage analysis with emphasis on methodology rather than computer programs. The first chapter presents basic genetic principles in a simple and intuitive manner. Crossing over is introduced and demonstrated in a simple example. Many sections in the first two chapters represent an elementary introduction, and readers without any statistical knowledge should be able to understand them. For other sections and later chapters, some facility with equations and simple algebra will be beneficial. No introduction to probability calculus is given; however, an outline of some statistical methods, particularly significance testing, is provided. This third edition reflects changes in the field over the past eight years. The author is affiliated with the Laboratory of Statistical Genetics at the Rockefeller University. Annotation c. Book News, Inc., Portland, OR (booknews.com)Product Details
Related Subjects
Meet the Author
Jurg Ott is a professor and head of the Laboratory of Statistical Genetics at Rockefeller University. He is editor-in-chief of Human Heredity and the author of the first generally available computer program on human linkage analysis (LIPED).
The Johns Hopkins University Press
Table of Contents