Anatomy of Gene Regulation: A Three-Dimensional Structural Analysis

by Panagiotis A. Tsonis

Overview

Anatomy of Gene Regulation is the first book to present the parts and processes of gene regulation at the three-dimensional level. Vivid structures of nucleic acids and their companion proteins are revealed in full-color, three dimensional form. Beginning with a general introduction to three-dimensional structures, the book looks at the organization of the genome, the structure of DNA, DNA replication and transcription, splicing, protein synthesis, and ultimate protein death. This concise and unique synthesis and its accompanying web site offer insight into gene regulation, and into the development of methods to interfere with regulation at diseased states.

Product Details

ISBN-13:	9780521800303
Publisher:	Cambridge University Press
Publication date:	01/13/2003
Pages:	298
Product dimensions:	6.73(w) x 9.84(h) x 0.75(d)

Table of Contents

Preface; 1. A general introduction to 3-D structures; 2. The higher organization of the genome; 3. Structure of DNA and telomeres; 4. DNA replication; 5. Transcription in prokaryotes; 6. Transcription in eukaryotes; 7. Splicing; 8. Modifications of mRNA; 9. Compartmentalization of transcription; 10. Protein synthesis; 11. The birth and death of proteins; Index.

Editorial Reviews

"Efforts such as this book are taking us in the right direction..." Nature Structural Biology

"The text discusses genetics and structural mechanics throughout. The synthesis of information offers insight into gene regulation and into the development of methods to interfere with regulation at diseased states. Anatomy of Gene Regulation is a textbook that is appropriate for both undergraduate and graduate students in genetics, molecular biology, structural biology, and biochemistry courses." Genetic Engineering News

"Panagiotis Tsonis's new book arguably is the first attempt at creating a structural biology's 'hall of fame' for most of the great players in gene regulation, replete with vivid, high resolution pictures of polymerases, nucleosomes, and ribosomes, just to mention a few. In this sense, the book is long overdue." Cell

"This excellent book is clearly written with students in mind, and I have no doubt that both undergraduate and graduate students will find it to be compulsive reading ... I know that I did." The Quarterly Review of Biology

From the Publisher