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Cognitive scientist Andrew, the neurological center of this book, is talking and talking, sometimes in the third person, about his accidental involvement in traumas beginning with the loss of his beloved pet dachshund and his sweet baby daughter. As his story proceeds, elements of the fantastic and unreliability begin to creep in, including stories of White House reveries, causing us to question our faith in him or even his existence. E.L. Doctorow's Andrew's Brain is an unsettling masterpiece, a work that extends our sense of what fiction can do.