Anesthetic Pharmacology: Physiologic Principles and Clinical Practice / Edition 1

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Here's the book that Anesthesiology called "a valuable reference irrespective of level of training or experience." This beautifully illustrated, full-color text offers more in-depth coverage of pharmacology and physiology, especially at the molecular level. This resource is perfect for board preparation, recertification, or for use by clinicians wanting to enhance their understanding of the mechanisms of drug action and find a framework from which they can approach the use of new drugs in practice.

• Offers more in-depth coverage of physiology than other texts of its kind.
• Examines the molecular biology of drugs and organ systems.
• Covers the mechanisms of drug action for the latest anesthetic drugs as well as all other drugs that anesthesiologists encounter in practice.
• Features comprehensive information on drug interactions.
• Complements the text with full-color figures that make every concept crystal clear.
• Serves as a perfect resource for board preparation, recertification, or daily clinical use.
• Provides a conceptual framework from which clinicians can approach the use of new drugs in practice.
• Includes outstanding chapters on Pharmacokinetic and Pharmacodynamic Principles of Drug Action, Signal Transduction Mechanisms, Motor Function, GI/Liver Physiology, Neuroprotective Agents, and Immunosuppressants.

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Editorial Reviews

Doody's Review Service
Reviewer: Jeffrey L. Apfelbaum, MD (University of Chicago Pritzker School of Medicine)
Description: In this first edition, the authors and editors provide a particularly comprehensive overview of both the mechanistic details of anesthetic drug action and the clinical context in which these anesthetic agents are used. Unlike many general textbooks in the medical specialty of anesthesiology, the editors have been extremely successful in focusing the chapter authors to be comprehensive in their consideration of the principles of drug action, the physiologic substrates of drug action, and the clinical application or pharmacologic basis of drug action.
Purpose: The editors state that they have designed this book to provide anesthesia trainees with a broad integrated introduction to the basic science and clinical use of drugs in the medical specialty of anesthesiology, as well as to provide practicing anesthesiologists with an enhanced understanding of the mechanisms of drug action and a conceptual framework with which to approach new drugs. Furthermore, they have intended to provide basic scientists with a clinical context to help understand the relevance of their work, and to provide a framework to direct future investigations in clinical studies to address clinically important questions as well as to resolve therapeutic deficiencies and discrepancies. The editors have succeeded in spectacular fashion in achieving the goals they have established in their design of this book.
Audience: As the editors suggest, trainees can read the book as a whole and get an in-depth background on anesthetic pharmacology. For practicing anesthesiologists, individual chapters are designed to stand on their own and can provide quick but thorough references for specific organ systems or classes of drugs. Additionally, the "practical aspects of drug use" section at the end of each chapter can serve as a quick reference for questions of immediate importance. For basic scientists, the book is designed to help them understand the clinical implications of their work and to spark investigation to address clinically important questions.
Features: This book serves as a complete and extraordinarily comprehensive reference for pharmacologic and physiologic issues of concern to anesthesiologists. It is organized into three sections. The initial section provides detailed theoretical and practical information about pharmacokinetics, pharmacodynamics, and cell signaling pathways. The second section focuses on the physiology of processes central to the actions of agents used in anesthesia and provides a detailed review of molecular, cellular, and integrated physiology. The third section covers the various classes of anesthetic agents and adjunctive agents organized according to their primary purpose. Although the emphasis of this section is on drugs primarily used as anesthetics, it also deals with sedatives/hypnotics, antibiotics, and chemotherapeutic agents. As an aid to the reader, each chapter has the same structure, and includes sections on mechanisms of action, clinical pharmacology, adverse effects, practical aspects of drug use, and dosage and administration guidelines. The editors have assembled 110 individual authors with expertise in both basic science and clinical medicine to serve as the principle authors. The collective background and expertise of these authors make them extraordinarily well-qualified as authorities in the field. Although the vast majority of contributors are from the United States, the book has a decidedly international flavor with contributors from Japan, Germany, France, United Kingdom, Canada, Australia, the Netherlands, Switzerland, and Israel.
Assessment: This is an extraordinarily well written and comprehensive book of exceptional quality; it fills a unique niche in bridging the chasm between basic science and clinical medicine in the medical specialty of anesthesiology. It is an invaluable addition to the library of any practitioner of the medical specialty of anesthesiology.
From the Publisher
"Readers will find Anesthetic Pharmacology a valuable reference irrespective of level of training or experience. It certainly deserves a place in every anesthesia departmental library and is highly recommended for those interested in staying on the leading edge of the specialty. " — Anesthesiology
"The excellent breadth and detail of this book could only be accomplished with the outstanding team of experts assembled by the editors." — Anesthesiology

"The chapters on drug action are dealt with in a manner of clarity not seen in most other volumes; these should be considered a MUST before the FRCA examinations. My own volume is already annotated with highlights that will be useful for both research and teaching.

"In summary, the editors and contributors are to be congratulated on the preparation of this volume."—British Journal of Anaesthesia 2005

5 Stars! from Doody
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Product Details

  • ISBN-13: 9780443065798
  • Publisher: Elsevier Health Sciences
  • Publication date: 1/2/2004
  • Edition description: Older Edition
  • Edition number: 1
  • Pages: 1028
  • Product dimensions: 8.90 (w) x 11.20 (h) x 2.10 (d)

Table of Contents

1. Pharmacokinetic and Pharmacodynamic Principles of Drug Action
2. Signal Transduction Mechanisms: Receptor-Effector Coupling
3. Signal Transduction Mechanisms: Ion Channels
4. Principles of Drug Biotransformation
5. Pharmacogenetics and Pharmacogenomics of Drug Action
6. Common Pharmacodynamic Drug Interactions in Anesthetic Practice
7. Pharmacoeconomics

8. The Generation and Propagation of Action Potentials
9. Synaptic Transmission
10. Neuromuscular Function
11. Sensory Processing: Peripheral Nociceptors
12. Sensory Processing: Primary Afferent Neuron/DRG
13. Sensory Processing: Spinal Cord
14. Autonomic Function
15. Neural Substrates for Behavior; Consciousness
16. Neural Substrates for Behavior; Pain
17. Cardiac Rhythm
18. Myocardial Performance
19. Vascular Reactivity
20. Lung Function: Ventilation, Oxygenation, Regulation
21. Renal Physiology
22. Liver Physiology

23. Inhalation Anesthetics
24. Intravenous Anesthetics: Barbiturates, Etomidate, Propofol, Ketamine, Steroids
25. Sedatives, Anxiolytics and Amnestics:
26. Analgesics: NSAIDs
27. Analgesics: Receptor Ligands and Opiate Narcotics
28. Analgesics: Receptor Ligands, Alpha-2 Adrenergic Receptor Agonists
29. Analagesics: Cannabinoids
30. Analgesics: Ion Channel Ligands/, Sodium Channel
31. Anticonvulsant Drugs
32. Neuroprotective Agents
33. Neuromuscular Blocking Agents
34. Sympathomimetics, Sympatholytic Drugs, Parasympathomimetics and Parasympatholytic Drugs
35. Antiarrhythmic Agents
36. Agents Used to Treat Myocardial Ischemia
37. Cardiovascular Pharmacology of Positive Inotropic Drugs
38. Myocardial Protection
39. Vasodilators
40. Bronchodilators, Corticosteroids and Anti-inflammatory Agents
41. Pulmonary Vasodilators
42. Diuretics
43. Electrolytes, Solutions, and Colloids
44. Antimotility and Antisecretory Agents
45. Antiemetics
46. Nutritional Supplements
47. Hypothalamic Pituitary-Adrenal Axis
48. Insulin
49. Drugs Affecting Lipid Metabolism
50. Antimicrobial Therapy
51. Chemotherapeutic Agents
52. Red Blood Cell Substitutes
53. Agents Affecting Coagulation and Platelet Function
54. Immunosuppressants

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