Angiogenesis and Cardiovascular Disease / Edition 1

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1999 Hard cover New in new dust jacket. New Sewn binding. Cloth over boards. 360 p. Contains: Illustrations. Audience: General/trade.

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Angiogenesis at both the clinical and functional scientific levels has emerged as an important area of study that exemplifies the importance of rapid translation of information ... learned at the laboratory bench to the bedside. There are compelling reasons to discuss the growth of new blood vessels, in both a clinical and mechanistic context, in a single book. Besides the wealth of information available on the biology of endothelial cells, growth factors, and developing vessels, recent technological developments have allowed the application of these advances to preclinical models of vascular disease, and to patients. This book was written to integrate the current understanding of basic mechanisms in vascular cell and molecular biology with the experimental and clinical implications of these advances. 360 pages including references, an extensive index, and charts, diagrams and drawings with 4 pages of color photographs. 8vo - over 7?" - 9?" tall. Read more Show Less

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Overview

Angiogenesis and Cardiovascular Disease provides a comprehensive review of the basic scientific and clinical advances in the field of angiogenesis, and its role in the human cardiovascular system. The material presented draws from multiple disciplines, integrating information in a single source. Topics addressed focus first on aspects of development and normal biology of the vasculature, and then on angiogenesis and how it is involved in the pathophysiology and therapy of ischemic cardiovascular disease. Vascular development, endothelial cell biology, the vascular matrix, and growth factors are discussed. Up to date information on current clinical trials, and practical advice concerning application to cardiovascular therapeutic options, are also stressed.

The book contains predominantly black-and-white illustrations, with some color illustrations.

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Product Details

  • ISBN-13: 9780195112351
  • Publisher: Oxford University Press, USA
  • Publication date: 1/28/1999
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 376
  • Product dimensions: 6.30 (w) x 9.30 (h) x 1.10 (d)

Table of Contents

Contributors
Pt. I Developmental and Normal Biology of the Vasculature
1 Embryonic Development of the Vascular System 3
2 Cellular Mechanisms of Angiogenesis 30
3 Heparan Sulfate Proteoglycans 60
4 Molecular Mechanisms of the Fibroblast Growth Factor Family 79
5 The Vascular Endothelial Growth Factor Family 101
6 Platelet-Derived Growth Factor and Other Modulators of Angiogenesis 128
Pt. II Angiogenesis in the Pathophysiology and Treatment of Ischemic Vascular Disease
7 Angiogenesis in Atherosclerosis and Restenosis 143
8 Collateral Circulation of the Heart 159
9 Angiogenesis in Nonischemic Myocardium 199
10 Animal Models of Angiogenesis in Cardiovascular Tissues 213
11 Growth Factor Delivery Strategies 238
12 Coronary Microcirculation and Angiogenesis 258
13 Therapeutic Angiogenesis in Myocardial Ischemia 289
14 Therapeutic Angiogenesis in Peripheral Limb Ischemia 321
Index 343
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