Angiogenesis and Direct Myocardial Revascularization / Edition 1

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Overview

An interdisciplinary panel of pioneers and opinion leaders review the basic, preclinical, clinical, and developmental pathways to new treatment strategies, such as therapeutic angiogenesis and myogenesis. The authors take advantage of new biological understanding, novel therapeutic targets, multiple available and well-studied therapeutic strategies, and the necessary imaging techniques to measure outcomes. Their in-depth discussions cover the identification of new therapeutic targets and pathways, the investigation of transcriptional factors, master switch molecules, cell-based approaches, chemokines, a better understanding of the effects of aging, endothelial dysfunction, and hypercholesterolemia in response to angiogenic stimuli. Highlights include examination of drug delivery problems, outcomes measure, stem therapy, high-risk interventions, development pathways, and future possibilities.

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Editorial Reviews

From The Critics
Reviewer: Rishi G Anand, MD (Ochsner Clinic Foundation)
Description: The authors of this book bring to the forefront of cardiovascular medicine the "no-option patients, " people who live with end-stage ischemic heart disease and are either no longer candidates for percutaneous or surgical revascularization or have exhausted or failed these modalities.
Purpose: The authors summarize pertinent basic science, clinical, and experimental research in order to provide a roadmap to physicians caring for patients with end-stage ischemic heart disease.
Audience: The book provides internists, cardiovascular specialists, researchers, and industry the most current treatment strategies espoused by internationally recognized pioneers and opinion leaders for helping patients with end-stage ischemic heart disease and peripheral vascular disease.
Features: The authors set the framework of managing "no-option" patients by discussing the mechanics of coronary microcirculation, then novel cellular and genetic therapeutic targets. Highlights of the book include new drug delivery systems, stem-cell therapy, gene therapy, and a discussion of transmyocardial laser revascularization.
Assessment: This book masterfully and authoritatively blends expert opinion with quality scientific research to provide specialists with insight into current treatment options for end-stage ischemic patients and future possibilities.

3 Stars from Doody
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Product Details

  • ISBN-13: 9781588291530
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 4/2/2004
  • Series: Contemporary Cardiology Series
  • Edition description: 2005
  • Edition number: 1
  • Pages: 372
  • Product dimensions: 6.35 (w) x 9.18 (h) x 1.02 (d)

Table of Contents

1 No-option patients : a growing problem 1
2 Transcriptional regulation of angiogenesis 19
3 Preclinical models and experience to date 37
4 The coronary microcirculation and angiogenesis 65
5 Local and regional vascular delivery for therapeutic angiogenesis and myogenesis 107
6 Imaging angiogenesis : a guide for clinical management and therapeutic trials 143
7 Myocardial angiogenesis : protein growth factors 185
8 Gene therapy for angiogenesis in the treatment of cardiovascular and peripheral arterial disease 215
9 Therapeutic angiogenesis in peripheral arterial disease : current approaches and future directions 245
10 Bone marrow cell transplantation for myocardial regeneration and therapeutic angiogenesis 261
11 Transplantation of embryonic stem cells for myocardial regeneration and angiogenesis 283
12 Skeletal myoblast transplantation for cardiac repair 311
13 Transmyocardial laser revascularization 329
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