Angiogenesis in Brain Tumors / Edition 1

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Overview

- Volume is divided into four sections, allowing easy navagation for researchers and practicing physicians

- Text includes clinical trials

- Written by leaders in the field

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Editorial Reviews

Doody's Review Service
Reviewer: Celso Agner, MD, MS, MSc (Michigan Neurology Partners)
Description: The development of neuro-oncology paralleled the acquisition of new modalities of imaging and neurochemical reactions capable of determining different markers and evidence of proliferation. Updates in the field are always necessary since new therapies may stem from scientific advances.
Purpose: The purpose of this book is to address the different factors involved in angiogenesis in brain tumors. These necessary and worthy objectives are well addressed by the authors.
Audience: Neurologists, neurophysiologists, and neurosurgeons would find in this an excellent contribution to the field. The authors are well known experts in clinical and surgical oncology. Many of them have set the main guidelines for the therapy of oncologic conditions.
Features: The 19 chapters are written by 36 authors. The book progresses from the basic science of CNS tumor angiogenesis to ways to clinically and radiographically determine these changes. Besides the excellent illustrations and examples, the book is replete with novel modalities of treatment that will potentially influence the manner CNS neoplasms are currently envisioned. One of the shortcomings is the absence of a dedicated neuroradiology section, in particular addressing strategies of identifying and treating proliferating neoplasms. In addition, there should be a description of potential methods to deliver growth factors, such as endovascular techniques. Those are not, however, major omissions and the book is overall of excellent quality for a justifiable price.
Assessment: This is a good source of information for neurological, neurosurgical, and general medical libraries. However, it is an addition to the major neuro-oncology textbooks already available.

3 Stars from Doody
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Product Details

  • ISBN-13: 9781402077043
  • Publisher: Springer US
  • Publication date: 2/29/2004
  • Series: Cancer Treatment and Research Series , #117
  • Edition description: 2004
  • Edition number: 1
  • Pages: 358
  • Product dimensions: 9.21 (w) x 6.14 (h) x 0.88 (d)

Table of Contents

Contributing Authors
1 Vasculogenesis and Angiogenesis 3
2 Morphogenesis of Embryonic CNS Vessels 33
3 Mathematical Modeling of Tumour-Induced Angiogenesis: Network Growth and Structure 51
4 Histologic Measures of Angiogenesis in Human Primary Brain Tumors 79
5 Angiogenesis in Transgenic Models of Multistep Angiogenesis 97
6 Models for Angiogenesis in Gliomas 115
7 Protocol for Isolation of HCEC 137
8 Protocol for MRI Monitoring of Orthotopic Glioma Growth in the Rat Brain 139
9 Methods to Study Angiogenesis in vitro 141
10 The Rabbit Corneal Pocket Assay for the Study of Angiogenesis 147
11 Role of Nitric Oxide in Tumor Angiogenesis 155
12 Angiogenesis-related Growth Factors in Brain Tumors 169
13 Role of VEGF in Developmental Angiogenesis and in Tumor Angiogenesis in the Brain 191
14 Hypoxia and Hypoxia Inducible Factors (HIF) as Important Regulators of Tumor Physiology 219
15 Vascular Microenvironment in Gliomas 249
16 Angiogenesis and Invasion in Gliomas 263
17 Metastasis and Angiogenesis 285
18 Inhibition of Angiogenesis as a Therapeutic Strategy Against Brain Tumors 307
19 Anti-Angiogenic Chemotherapy in Central Nervous System Tumors 337
Index 351
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