Angiogenesis in Brain Tumors / Edition 1

Hardcover (Print)
Buy New
Buy New from
Used and New from Other Sellers
Used and New from Other Sellers
from $28.05
Usually ships in 1-2 business days
(Save 91%)
Other sellers (Hardcover)
  • All (8) from $28.05   
  • New (7) from $50.92   
  • Used (1) from $28.05   


The mutual relationship between tumor growth and concomitant neovascularization offers important insight into the biology of brain tumors and the development of new treatment strategies. Many of the early findings in the biology of angiogenesis have been investigated using brain tumor models. Angiogenesis in Brain Tumors is part of the "Cancer Treatment and Research" book series and this volume provides an overview of the biology of angiogenesis in the central nervous system, the role of angiogenesis in brain tumor development and growth, and therapeutic applications including clinical trials. 'Angiogenesis is a critical component of tumor growth. This text evaluates the role of neovascularization in brain tumor development and growth, and presents therapeutic applications including clinical trials. Distinguished investigators in the field discuss the critical signaling cascades that affect angiogenesis and evaluate strategies that inhibit the process that may provide therapeutic benefit against these devastating cancers.'

Read More Show Less

Editorial Reviews

Doody's Review Service
Reviewer: Celso Agner, MD, MS, MSc (Michigan Neurology Partners)
Description: The development of neuro-oncology paralleled the acquisition of new modalities of imaging and neurochemical reactions capable of determining different markers and evidence of proliferation. Updates in the field are always necessary since new therapies may stem from scientific advances.
Purpose: The purpose of this book is to address the different factors involved in angiogenesis in brain tumors. These necessary and worthy objectives are well addressed by the authors.
Audience: Neurologists, neurophysiologists, and neurosurgeons would find in this an excellent contribution to the field. The authors are well known experts in clinical and surgical oncology. Many of them have set the main guidelines for the therapy of oncologic conditions.
Features: The 19 chapters are written by 36 authors. The book progresses from the basic science of CNS tumor angiogenesis to ways to clinically and radiographically determine these changes. Besides the excellent illustrations and examples, the book is replete with novel modalities of treatment that will potentially influence the manner CNS neoplasms are currently envisioned. One of the shortcomings is the absence of a dedicated neuroradiology section, in particular addressing strategies of identifying and treating proliferating neoplasms. In addition, there should be a description of potential methods to deliver growth factors, such as endovascular techniques. Those are not, however, major omissions and the book is overall of excellent quality for a justifiable price.
Assessment: This is a good source of information for neurological, neurosurgical, and general medical libraries. However, it is an addition to the major neuro-oncology textbooks already available.

3 Stars from Doody
Read More Show Less

Product Details

  • ISBN-13: 9781402077043
  • Publisher: Springer US
  • Publication date: 2/29/2004
  • Series: Cancer Treatment and Research Series, #117
  • Edition description: 2004
  • Edition number: 1
  • Pages: 358
  • Product dimensions: 9.21 (w) x 6.14 (h) x 0.88 (d)

Table of Contents

Contributing Authors
1 Vasculogenesis and Angiogenesis 3
2 Morphogenesis of Embryonic CNS Vessels 33
3 Mathematical Modeling of Tumour-Induced Angiogenesis: Network Growth and Structure 51
4 Histologic Measures of Angiogenesis in Human Primary Brain Tumors 79
5 Angiogenesis in Transgenic Models of Multistep Angiogenesis 97
6 Models for Angiogenesis in Gliomas 115
7 Protocol for Isolation of HCEC 137
8 Protocol for MRI Monitoring of Orthotopic Glioma Growth in the Rat Brain 139
9 Methods to Study Angiogenesis in vitro 141
10 The Rabbit Corneal Pocket Assay for the Study of Angiogenesis 147
11 Role of Nitric Oxide in Tumor Angiogenesis 155
12 Angiogenesis-related Growth Factors in Brain Tumors 169
13 Role of VEGF in Developmental Angiogenesis and in Tumor Angiogenesis in the Brain 191
14 Hypoxia and Hypoxia Inducible Factors (HIF) as Important Regulators of Tumor Physiology 219
15 Vascular Microenvironment in Gliomas 249
16 Angiogenesis and Invasion in Gliomas 263
17 Metastasis and Angiogenesis 285
18 Inhibition of Angiogenesis as a Therapeutic Strategy Against Brain Tumors 307
19 Anti-Angiogenic Chemotherapy in Central Nervous System Tumors 337
Index 351
Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Terms of Use.
  • - Barnes & reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)