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Angiogenesis in Brain Tumors / Edition 1
     

Angiogenesis in Brain Tumors / Edition 1

by Matthias Kirsch
 

ISBN-10: 1402077041

ISBN-13: 9781402077043

Pub. Date: 02/29/2004

Publisher: Springer US

The mutual relationship between tumor growth and concomitant neovascularization offers important insight into the biology of brain tumors and the development of new treatment strategies. Many of the early findings in the biology of angiogenesis have been investigated using brain tumor models. Angiogenesis in Brain Tumors is part of the "Cancer Treatment and

Overview

The mutual relationship between tumor growth and concomitant neovascularization offers important insight into the biology of brain tumors and the development of new treatment strategies. Many of the early findings in the biology of angiogenesis have been investigated using brain tumor models. Angiogenesis in Brain Tumors is part of the "Cancer Treatment and Research" book series and this volume provides an overview of the biology of angiogenesis in the central nervous system, the role of angiogenesis in brain tumor development and growth, and therapeutic applications including clinical trials. 'Angiogenesis is a critical component of tumor growth. This text evaluates the role of neovascularization in brain tumor development and growth, and presents therapeutic applications including clinical trials. Distinguished investigators in the field discuss the critical signaling cascades that affect angiogenesis and evaluate strategies that inhibit the process that may provide therapeutic benefit against these devastating cancers.'

Product Details

ISBN-13:
9781402077043
Publisher:
Springer US
Publication date:
02/29/2004
Series:
Cancer Treatment and Research Series , #117
Edition description:
2004
Pages:
358
Product dimensions:
6.10(w) x 9.25(h) x 0.03(d)

Related Subjects

Table of Contents

Contributing Authorsvii
APrinciples of Angiogenesis in the Central Nervous System1
1.Vasculogenesis and Angiogenesis3
2.Morphogenesis of Embryonic CNS Vessels33
3.Mathematical Modeling of Tumour-Induced Angiogenesis: Network Growth and Structure51
BAssessment of Angiogenesis in Neuro-Oncology77
4.Histologic Measures of Angiogenesis in Human Primary Brain Tumors79
5.Angiogenesis in Transgenic Models of Multistep Angiogenesis97
6.Models for Angiogenesis in Gliomas115
7.Protocol for Isolation of HCEC137
8.Protocol for MRI Monitoring of Orthotopic Glioma Growth in the Rat Brain139
9.Methods to Study Angiogenesis in vitro141
10.The Rabbit Corneal Pocket Assay for the Study of Angiogenesis147
CBrain Tumor Related Angiogenesis153
11.Role of Nitric Oxide in Tumor Angiogenesis155
12.Angiogenesis-related Growth Factors in Brain Tumors169
13.Role of VEGF in Developmental Angiogenesis and in Tumor Angiogenesis in the Brain191
14.Hypoxia and Hypoxia Inducible Factors (HIF) as Important Regulators of Tumor Physiology219
15.Vascular Microenvironment in Gliomas249
16.Angiogenesis and Invasion in Gliomas263
17.Metastasis and Angiogenesis285
DClinical Application in Neuro-Oncology305
18.Inhibition of Angiogenesis as a Therapeutic Strategy Against Brain Tumors307
19.Anti-Angiogenic Chemotherapy in Central Nervous System Tumors337
Index351

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