Animal Models in Cardiovascular Research / Edition 3

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Animal Models in Cardiovascular Research covers both historical and recent advances in our understanding of the cardiovascular system from studies conducted in animal models. The last decade has seen an explosion in the use of very specialized congenic and transgenic animal models that were not described in the previous two editions. The results of many of these studies provide a sometime bewildering array of redundant, overlapping and competing molecular pathways demanding further study. This third edition is designed to provide a better basis for understanding and using animal models in the current climate of background knowledge and information. The first and second editions of Animal Models in Cardiovascular Research emphasized normal cardiovascular parameters and the cardiovascular effects of a wide variety of drugs commonly used for restraint, anesthesia and pain control in the various animal species. The third edition is focused on the avalanche of genetic, molecular and protein-based information generated from the use of both congenic and transgenic animal models. Updated and expanded chapters provide new information generated from classical, congenic and transgenic animal models used to study ischemic heart disease, cardiomyopathy, heart failure, hypertension and atherosclerotic disease. Completely new chapters in this third edition describe the techniques, problems and pitfalls associated with the measurement of cardiac and vascular function and ventricular/arterial coupling dynamics in various animal models. There is a new chapter detailing problems and pitfalls associated with isolated heart preparations and another describing animal models for the study of neurohumeral and CNS control of the cardiovascular system.

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Product Details

  • ISBN-13: 9781441930705
  • Publisher: Springer New York
  • Publication date: 10/29/2010
  • Edition description: Softcover reprint of hardcover 3rd ed. 2009
  • Edition number: 3
  • Pages: 431
  • Product dimensions: 6.14 (w) x 9.21 (h) x 0.93 (d)

Meet the Author

Dr. David R. Gross entered private veterinary practice after earning the DVM degree from Colorado State University in 1960. In 1974 he was awarded the PhD degree in physiology from the Ohio State University beginning a 36-year career in academics that culminated as professor and head of the Department of Veterinary Biosciences in the College of Veterinary Medicine, University of Illinois, Urbana-Champaign. Dr. Gross’ research career encompassed 58 funded projects totaling over $5.5 million and 91 papers published in refereed journals using a wide variety of animal models. Ironically his three most-cited research papers received no external funding. He and his colleagues showed that feeding dietary cholesterol to rabbits induced Alzheimer’s-like lesions in the brain. Their work also showed that surgery involving cardiopulmonary bypass resulted in Alzheimer’s-like brain lesions in pigs. With another group of colleagues he helped pioneer minimally invasive coronary artery bypass grafting techniques using the pig as a model.

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Table of Contents

1. General principles of animal selection and normal physiological values 2. Anesthesia, chemical restraint (sedation), and analgesia 3. Normal cardiovascular parameters 4. Measuring cardiac function 5. Measuring vascular function and ventricular/arterial coupling dynamics 6. Isolated heart preparations, problems and pitfalls 7. Cardiovascular effects anesthetics, sedatives and post-operative analgesic agents 8. Iatrogenic and naturally occurring animal models of valvular, infectious and arrhythmic cardiovascular disease 9. Iatrogenic models of ischemic heart disease 10. Iatrogenic, transgenic and naturally occurring models of cardiomyopathy and heart failure 11. Iatrogenic and transgenic models of hypertension 12. Iatrogenic and transgenic models of atherosclerotic disease 13. Animal models for the study of neurohumeral and central neural control of the cardiovascular system 14. Cardiovascular studies involving other specific genetic knockouts

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