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Animal Models in Cardiovascular Research covers both historical and recent advances in our understanding of the cardiovascular system from studies conducted in animal models. The last decade has seen an explosion in the use of very specialized congenic and transgenic animal models that were not described in the previous two editions. The results of many of these studies provide a sometime bewildering array of redundant, overlapping and competing molecular pathways demanding further study. This third edition is designed to provide a better basis for understanding and using animal models in the current climate of background knowledge and information.
The first and second editions of Animal Models in Cardiovascular Research emphasized normal cardiovascular parameters and the cardiovascular effects of a wide variety of drugs commonly used for restraint, anesthesia and pain control in the various animal species. The third edition is focused on the avalanche of genetic, molecular and protein-based information generated from the use of both congenic and transgenic animal models. Updated and expanded chapters provide new information generated from classical, congenic and transgenic animal models used to study ischemic heart disease, cardiomyopathy, heart failure, hypertension and atherosclerotic disease.
Completely new chapters in this third edition describe the techniques, problems and pitfalls associated with the measurement of cardiac and vascular function and ventricular/arterial coupling dynamics in various animal models. There is a new chapter detailing problems and pitfalls associated with isolated heart preparations and another describing animal models for the study of neurohumeral and CNS control of the cardiovascular system.
1. General principles of animal selection and normal physiological values 2. Anesthesia, chemical restraint (sedation), and analgesia 3. Normal cardiovascular parameters 4. Measuring cardiac function 5. Measuring vascular function and ventricular/arterial coupling dynamics 6. Isolated heart preparations, problems and pitfalls 7. Cardiovascular effects anesthetics, sedatives and post-operative analgesic agents 8. Iatrogenic and naturally occurring animal models of valvular, infectious and arrhythmic cardiovascular disease 9. Iatrogenic models of ischemic heart disease 10. Iatrogenic, transgenic and naturally occurring models of cardiomyopathy and heart failure 11. Iatrogenic and transgenic models of hypertension 12. Iatrogenic and transgenic models of atherosclerotic disease 13. Animal models for the study of neurohumeral and central neural control of the cardiovascular system 14. Cardiovascular studies involving other specific genetic knockouts