Animal Models in Toxicology, Second Edition / Edition 2 by Shayne C. Gad, Gad C. Gad | | 9780824754075 | Hardcover | Barnes & Noble
Animal Models in Toxicology, Second Edition / Edition 2

Animal Models in Toxicology, Second Edition / Edition 2

by Shayne C. Gad, Gad C. Gad
     
 

ISBN-10: 0824754077

ISBN-13: 9780824754075

Pub. Date: 10/28/2006

Publisher: Taylor & Francis

Reflecting more than a decade’s worth of changes, Animal Models in Toxicology, Second Edition is a practical guide to the common statistical problems encountered in toxicology and the methodologies that are available to solve them. The book presents a historical review of the use of animal models and an overview of broad considerations of metabolism

Overview

Reflecting more than a decade’s worth of changes, Animal Models in Toxicology, Second Edition is a practical guide to the common statistical problems encountered in toxicology and the methodologies that are available to solve them. The book presents a historical review of the use of animal models and an overview of broad considerations of metabolism and relevance used in toxicology. Individual chapters covering the eight major species used in toxicology and experimental biology form the core of the book. With contributions from experts in toxicology, toxicological pathology, and species-specific metabolism, each of these chapters provide an excellent introductory “course” along with guidance to the literature for more detailed understanding.

The book goes on to make the case for a range of species not commonly used for safety assessment studies but which may provide useful alternative models for some specific endpoints. The chapter authors discuss special considerations regarding the evaluation and interpretation of the clinical pathology of the eight major model species as well as how to select a model species and how to extrapolate the results to humans. They detail potential pitfalls and situations that cause either human or model to be significantly more sensitive than the other or totally irrelevant to each other. The book concludes with an overview of the increasingly complex laws and regulations that govern how laboratory animals are obtained, maintained, and utilized, and an appendix that provides a quick guide to commercial sources of laboratory animals.

Product Details

ISBN-13:
9780824754075
Publisher:
Taylor & Francis
Publication date:
10/28/2006
Series:
Drug and Chemical Toxicology Series
Edition description:
REV
Pages:
952
Product dimensions:
7.20(w) x 10.10(h) x 2.40(d)

Table of Contents

Introduction, S.C. Gad The Mouse
Toxicology, S.C. Gad
Pathology, C.H. Frith, D.G. Goodman, and B.G. Boysen
Metabolism, S.C. Gad The Rat
Toxicology, M.D. Johnson
Pathology, S.C. Gad
Metabolism, S.C. Gad The Hamster
Toxicology, S.C. Gad
Pathology, F.G. Hess
Metabolism, S.C. Gad
The Guinea Pig
Toxicology, S.C. Gad
Pathology, J.C. Peckham
Metabolism, S.C. Gad The Rabbit
Toxicology, C.M. Salamon and K.M. MacKenzie
Pathology, J.C. Peckham
Metabolism, S.C. Gad The Ferret
Toxicology, D.E. McLain
Pathology, S. Chandra
Metabolism, S.C. Gad The Dog
Toxicology, G.C. Haggerty
Pathology, J.C. Peckham and R.W. Thomassen
Metabolism, S.C. Gad Primates
Toxicology, M.D. Walker, J.K. Nelson, and J.C. Bernal
Pathology, G.B. Baskin
Metabolism, S.C. Gad The Minipig
Toxicology, S.C. Gad
Pathology, Z. Dincer and O. Svendsen
Metabolism, M.T. Skaanild
Alternative, S.C. Gad
Clinical Pathology of Laboratory Animals, R.L. Hall
Model Selection and Scaling, S.C. Gad
Susceptibility Factors, S.C. Gad
Laws and Regulations Governing Animal Care and Use in Research, S.C. Gad
Appendix: Commercial Sources of Laboratory Animals, S.C. Gad Index

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