Animal Models in Toxicology

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Providing step-by-step procedures specifically adapted to each of the major animal model species and describing the basic in vivo techniques used in toxicology and pharmacology, this single-source reference presents the information necessary to select appropriate in vivo models, design experiments, and interpret experimental results.;Furnishing physiological, preproductive, histopathological, clinical pathology, and anaesthesia data for the major laboratory species, Animal Models in Toxicology supplies a ...

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Overview

Providing step-by-step procedures specifically adapted to each of the major animal model species and describing the basic in vivo techniques used in toxicology and pharmacology, this single-source reference presents the information necessary to select appropriate in vivo models, design experiments, and interpret experimental results.;Furnishing physiological, preproductive, histopathological, clinical pathology, and anaesthesia data for the major laboratory species, Animal Models in Toxicology supplies a historical overview; discusses proper dosing techniques; examines common background diseases; details distinctive metabolic characteristics; demonstrates how to extrapolate results; and explicates animal welfare regulations.;With over 2600 literature citations and an appendix that lists the major commercial sources of laboratory animals, Animal Models in Toxicology is a comprehensive reference for toxicologists, pharmacologists, physiologists, and biochemists in pharmaceutical, clinical, biotechnology and contract laboratories; laboratory animal scientists and technicians; and upper-level undergraduate and graduate courses in animal pharmacology, experimental toxicology, comparative physiology, and experimental procedure.

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Product Details

Table of Contents

Introduction, Christopher P. Chengelis and Shayne Cox Gad. Part 1 The rat: toxicology, David E. Semler; pathology, Shayne Cox Gad; metabolism, Christopher P. Chengelis. Part 2 The mouse: toxicology, James M. Andress; pathology, Charles H. Frith et al; metabolism, Chyung S. Cook. Part 3 The hamster: toxicology, Anne C. Costello; pathology, Frederick G. Hess; metabolism, Christopher P. Chengelis. Part 4 The guinea pig: toxicology, Shayne Cox Gad; pathology, John C. Peckham; metabolism, Christopher P. Chengelis. Part 5 The rabbit: toxicology, Clare M. Salamon and Karen M. MacKenzie; pathology, Robert R. Dahlgren; metabolism, Chyung S. Cook. Part 6 The ferret: toxicology, Daniel E. McLain and Richard M. Hoar; pathology, Glen K. Miller; metabolism, Christopher P. Chengelis. Part 7 The dog: toxicology, Gillian C. Haggerty; pathology, Robert W. Thomassen; metabolism, Christopher P. Chengelis. Part 8 Nonhuman primates: toxicology, Gene B. Fuller et al; pathology, Curtis D. Port; metabolism, Christopher P. Chengelis. Alternative species, Christopher P. Chengelis; clinical pathology of laboratory animals, Robert L. Hall; model selection and scaling, Shayne Cox Gad; susceptibility factors, Shayne Cox Gad; laws and regulations governing animal care and use in research, Curtis D. Port; appendix - commercial sources of laboratory animals, Shayne Cox Gad.

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