Animal Models in Toxicology, Third Edition

Animal Models in Toxicology, Third Edition

by Shayne C. Gad
     
 

Animal Models in Toxicology is a single-source reference for the use of animal models in toxicology. Chapters cover nine species used in toxicology and experimental biology. With contributions from experts in toxicology, toxicological pathology, and species-specific metabolism, each of these chapters provides an excellent introductory "course" along with

Overview

Animal Models in Toxicology is a single-source reference for the use of animal models in toxicology. Chapters cover nine species used in toxicology and experimental biology. With contributions from experts in toxicology, toxicological pathology, and species-specific metabolism, each of these chapters provides an excellent introductory "course" along with guidance to the literature for a more detailed understanding.

This edition includes five new chapters. The first of these provides specific and detailed guidance on the humane, efficient, and effective performance of necropsies for laboratory animals. Other new chapters discuss new technologies available for laboratory animal research—imaging technologies, use of telemetry in animal studies, transgenic animal models, and immunology endpoint for assessment. Also provided is an overview of the increasingly complex laws and regulations that govern how laboratory animals are obtained, maintained, and utilized. A helpful appendix provides a quick guide to commercial sources of laboratory animals.

Editorial Reviews

From the Publisher
"…should be in every toxicology laboratory that performs research involving animals. No other book … provides the same breadth and depth of information as found here…"
—Michele T. Pritchard, PhD, University of Kansas Medical Center in Doody’s Book Reviews
Doody's Review Service
Reviewer: Michele T Pritchard, PhD (University of Kansas Medical Center)
Description: This incredibly comprehensive reference on the use of animals in toxicological research includes specifics on several commonly used species, normal laboratory values, and regulatory concerns that govern the use of animals in research settings.
Purpose: This book helps fill gaps in toxicological education by providing students and mentors alike with enough knowledge to improve the choice of animal used in toxicological research, optimal study designs, and techniques/assays for evaluating the toxicological impact of chemicals on specific organisms. The framework the book uses is how the four "Rs" (refinement, reduction, replacement, responsibility) are critical for the quality and extrapolation of animal-based research to humans as well as to animals. Indeed, the fourth "R" is the editor's addition, emphasizing how important and serious appropriate animal research is. An interesting and eloquent discussion of the historical use of animals as well as the benefits of animal use for research helps put this difficult necessity into appropriate perspective.
Audience: This is a valuable reference for students, researchers in basic and translational research labs, and similar folks in industrial settings. Toxicology educators also will find this to be an essential reference.
Features: In significant detail, this book profiles nine different species commonly used in toxicological research, covering the advantages and disadvantages for each species as well as strains within a species. It also provides recommendations for use. This edition contains five new chapters covering laws that govern the use of animals in research in the U.S., the EU, and other countries as well as humane, effective, and efficient performance of necropsies, new technologies such as imaging and telemetry, transgenic animals, and immunology in a toxicology setting. Extensive references and many tables, figures, and images help create an indispensable resource for anyone who uses animals in research.
Assessment: This is a nice update of the second edition published in 2007 and should be in every toxicology laboratory that performs research involving animals. No other book, previous editions aside, provides the same breadth and depth of information as found here. Books with similar content are not specific to the science of toxicology (e.g. Handbook of Laboratory Animal Science, 3rd edition, Hau and Schapiro (CRC Press, 2013)), or concentrate on single organ toxicology (e.g. Assessing Ocular Toxicology in Laboratory Animals, Weir and Collins (Humana Press, 2013)). In addition, it does not appear that other books on laboratory animal-based research spend any time discussing regulatory issues, which makes this one absolutely unique. It was a pleasure to review it.

Product Details

ISBN-13:
9781466554283
Publisher:
Taylor & Francis
Publication date:
08/05/2015
Pages:
1152

Meet the Author

Edited by

Shayne Cox Gad, PhD, DABT, is the principal of Gad Consulting Services in Raleigh, North Carolina. He has more than 38 years of broad-based experience in toxicology, drug, device development, document preparation, statistics, and risk assessment, having previously been the director of toxicology and pharmacology for Synergen, director of medical affairs technical support system services for Becton Dickinson, and senior director of product safety and pharmacokinetics for G.D. Searle. He is past president of the American College of Toxicology and Roundtable of Toxicology Consultants and a board-certified toxicologist. Dr. Gad has published 47 books and more than 350 chapters, papers, and abstracts.

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