Animal Models of Dementia / Edition 1

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Overview

With an ever-increasing elderly population and the resultant rising levels of dementia-related disorders, preclinical research based on animal models is pivotal to our knowledge of underlying molecular mechanisms and drug discovery aiming at the development of therapeutic strategies alleviating or preventing the neurological devastation. In Animal Models of Dementia, expert researchers provide contributions that stress the importance of extensively validated animal models in drug discovery and development in order to predict clinical activity. Beginning with general aspects of animal modeling, related ethical issues, and essential methodological considerations, the highly detailed volume then continues with various levels of model validation, including pathological, behavioral, neurochemical, pharmacological, and imaging aspects, followed by sections focused on specific disorders, such as Alzheimer's disease, Parkinson's disease, metachromatic leukodystrophy and adrenoleukodystrophy, amyotrophic lateral sclerosis, frontotemporal dementia as well as vascular dementia and more. As a volume in the renowned Neuromethods series, this book offers a detailed, yet accessible, overview of currently available animal models in the field of dementia research, and touches, as well, upon more general areas linked to the development and use of animal models. Comprehensive and efficient, Animal Models of Dementia will significantly aid both experienced animal researchers as well as investigators on the verge of beginning animal model-based dementia research.

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Editorial Reviews

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From the reviews:
“A great add-on to more basic textbooks on mechanisms of dementia. The book not only nicely summarizes ongoing efforts to model dementia but also describes how to investigate underlying mechanisms at various level of complexity. … Importantly, leading mouse models are discussed, which is very useful for newcomers to the field, as there are a lot of different models. … Additionally, the book provides information about ethics on animal experimentation and information on intellectual property, issues that can be rarely found in textbooks.” (Karl Peter Giese, British Journal of Clinical Pharmacology, May, 2011)
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Product Details

  • ISBN-13: 9781607618973
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 12/1/2010
  • Series: Neuromethods Series , #48
  • Edition description: 2011
  • Edition number: 1
  • Pages: 732
  • Product dimensions: 7.30 (w) x 10.20 (h) x 2.00 (d)

Table of Contents

Part I: Animal Modeling: General and Ethical Aspects and Drug Discovery Pipeline

1. General Introduction to Animal Models of Human Conditions
Peter Paul De Deyn and Debby Van Dam

2. Animal Models of Dementia: Ethical Considerations
I. Anna S. Olsson and Peter Sandøe

3. The Role of Rodent Models in the Drug Discovery Pipeline for Dementia
Debby Van Dam and Peter Paul De Deyn

Part II: Methodological Considerations when Developing Animal Models of Dementia

4. Species, Strain, and Gender Issues in the Development and Validation of Animal Models of Dementia
Annemie Van Dijck, Debby Van Dam, and Peter Paul De Deyn

5. Transgenic and Gene Targeted Models of Dementia
Ronald A. Conlon

6. Transgenic Animals and Intellectual Property Concerns
Susan L. Stoddard and James A. Rogers, III

Part III: Validation of Animal Models of Dementia

7. Pathological Validation of Animal Models of Dementia
Daniel Pirici, Christine Van Broeckhoven, and Samir Kumar-Singh

8. Behavioral Validation in Animal Models of Dementia
Debby Van Dam, Annemie Van Dijck, and Peter Paul De Deyn

9. Pharmacological Validation in Animal Models of Dementia
Hugo Geerts

10. Validation of Animal Models of Dementia: Neurochemical Aspects
Giancarlo Pepeu and Maria Cristina Rosi

11. Validation of Dementia Models Employing Neuroimaging Techniques
Greet Vanhoutte, Adriaan Campo, and Annemie Van der Linden

Part IV: Animal Models of Alzheimer’s Disease

12. Drosophila melanogaster as a Model Organism for Dementia
Maria E. Giannakou and Damian C. Crowther

13. Caenorhabditis elegans as a Model Organism for Dementia
Tjakko J. van Ham and Ellen A.A. Nollen

14. Zebrafish (Danio rerio) as a Model Organism for Dementia
Rob Willemsen, Sandra van ’t Padje, John C. van Swieten, and Ben A. Oostra

15. Spontaneous Vertebrate Models of Alzheimer Dementia: Selectively Bred Strains (SAM Strains)
Renã A. Sowell and D. Allan Butterfield

16. Lesion-Induced Vertebrate Models of Alzheimer Dementia
Adolfo Toledano and Maria Isabel Álvarez

17. Aβ Infusion and Related Models of Alzheimer Dementia
Patricia A. Lawlor and Deborah Young

18. APP-Based Transgenic Models: The PDAPP Model
Jacob M. Basak and David M. Holtzman

19. APP-Based Transgenic Models: The Tg2576 Model
Robert M.J. Deacon

20. APP-Based Transgenic Models: The APP23 Model
Debby Van Dam and Peter Paul De Deyn

21. Presenilin-Based Transgenic Models of Alzheimer’s Dementia
Yuji Yoshiike and Akihiko Takashima

22. APOE-Based Models of “Pre-Dementia”
Patrick M. Sullivan

23. TAU Models
Nicolas Sergeant and Luc Buée

24. The 3xTg-AD Mouse Model: Reproducing and Modulating Plaque and Tangle Pathology
Michael Sy, Masashi Kitazawa, and Frank LaFerla

Part V: Animal Models of Non-Alzheimer Neurodegenerative Disease

25. Cognitive Dysfunction in Genetic Mouse Models of Parkinsonism
Sheila M. Fleming, J. David Jentsch, and Marie-Françoise Chesselet

26. Mouse Models of Metachromatic Leukodystrophy and Adrenoleukodystrophy
Patrick Aubourg, Caroline Sevin, and Nathalie Cartier

27. Animal Models of Amyotrophic Lateral Sclerosis
Ludo Van Den Bosch

28. Animal Models of Frontotemporal Dementia
Hana N. Dawson and Daniel T. Laskowitz

Part VI: Animal Models of Vascular Dementia

29. CADASIL: Molecular Mechanisms and Animal Models
Karl J. Fryxell

30. Spontaneously Hypertensive Rat (SHR): An Animal Model of Vascular Brain Disorder
Francesco Amenta and Daniele Tomassoni

Part VII: Animal Models of Normal Pressure Hydrocephalus

31. Animals Models of Normal Pressure Hydrocephalus
Petra M. Klinge

Part VIII: Animal Models of Traumatic Dementia

32. Animal Models of Traumatically-Induced Dementia
Jennifer E. Slemmer, Mohammed Z. Hossain, and John T. Weber

Part IX: Animal Models of Toxic Dementia

33. Animal Models of Alcohol-Induced Dementia
Angela Maria Ribeiro and Silvia R. Castanheira Pereira

34. Animal Models of Metallic Dementia
Luigi F. Rodella

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