Animal Models of Human Cognitive Aging / Edition 1

Hardcover (Print)
Buy New
Buy New from
Used and New from Other Sellers
Used and New from Other Sellers
from $38.50
Usually ships in 1-2 business days
(Save 82%)
Other sellers (Hardcover)
  • All (9) from $38.50   
  • New (7) from $38.50   
  • Used (2) from $218.99   


Significant improvements in lifestyle and medical science are leading to an ever increasing elderly population in the United States and other developed nations. The U.S. census bureau estimates the number of people over 65 will nearly double by 2030, and that the elderly population will comprise nearly one-fifth of the world's entire population within the next twenty years. In Animal Models of Human Cognitive Aging, Jennifer Bizon, Alisa Woods, and a panel of international authorities comprehensively discuss the use of animal models as a tool for understanding cognitive changes associated with the aging process. The book provides substantive background on the newest and most widely used animal models in studies of cognition and aging, while detailing the normal and pathological processes of brain aging of humans in relation to those models. Additional chapters comprehensively review frontal cortical deficits and executive function in primates as related to humans, and the use of transgenic modulation in mice to model Alzheimer's and other age-related diseases. Groundbreaking and authoritative, Animal Models of Human Cognitive Aging provides a valuable resource for Neuroscientists, Gerontological Scientists, and all aging medicine researchers, while serving as a primer for understanding current brain aging studies.

Read More Show Less

Editorial Reviews

Doody's Review Service
Reviewer: David O. Staats, MD (University of Oklahoma Health Sciences Center)
Description: This multiauthored series of essays describe animal models of human cognitive aging. With the clinical importance of memory disorders in late life, understanding which models of the aging brain are best suited to yield information about human aging and its diseases is timely.
Purpose: The purpose is to provide background information on the most widely used animal models of cognition and aging. By doing so, researchers can pick the animal model best suited to their needs, understanding the benefits and drawbacks of each animal model.
Audience: The audience includes the community, working in neurobiology and interested in age-related changes in brain function. The authors are all experts in this area.
Features: The first of the eight essays reviews the differences between normal age-related changes in brain function and the development of diseases like Alzheimer's. In a sort of general field theory, factors giving resistance to dementia are cited, especially exercise. This is followed by essays on brain aging in nonhuman primates, the prefrontal cortex in rats and man, and different cognitive rat models of human aging. Then comes a chapter comparing mice and rats; mice have a different field biology than rats, and their behavior, more furtive and anxious, reflects that they are dinner for many predators. Next are chapters on amyloid and Tau protein in rodent brain aging and a subtle chapter on the effects of sex and steroid hormones on the brain. The concluding essay is a fascinating look at how we tell (experience) time and the use of this perception as a model of the aging brain.
Assessment: This book is a winner from start to end. Each essay is carefully written with excellent annotation of the references. The synthesis of information is particularly noteworthy. For example, the aging of the brain is not the same in different areas of the brain, and the effects on functioning are not the same either. Exercise exerts a wonderful trophic factor in the brain. Then, in rodent models, an understanding of how different strains age permits selections of ages of these rodents so that they are comparatively at the same biological age (think dog years). Everyone interested in experimental models of the aging of the human brain will derive timely and useful information by delving into this excellent book.
Read More Show Less

Product Details

  • ISBN-13: 9781588299963
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 12/12/2008
  • Series: Aging Medicine Series
  • Edition description: 2009
  • Edition number: 1
  • Pages: 208
  • Product dimensions: 6.30 (w) x 9.40 (h) x 0.60 (d)

Table of Contents

Chapter 1. Normal and Pathological Aging – From Animals to Humans Nicole C. Berchtold and Carl W. Cotman Chapter 2. Non-Human Primate Models of Cognitive Aging Agnès Lacreuse and James G. Herndon Chapter 3. Age-related Effects on Prefrontal Cortical Systems: Translating Between Rodents, Nonhuman Primates, and Humans Mark G. Baxter Chapter 4. Comparison of Different Cognitive Rat Models of Human Aging Candi LaSarge and Michelle Nicolle Chapter 5. Mouse Models of Cognitive Aging: Behavioral Tasks and Neural Substrates Michael E. Calhoun Chapter 6. Impact of Aß and Tau on Cognition in Mouse Models of Alzheimer’s Disease Maya A. Koike, Kristoffer Myczek, Kim N. Green and Frank M. LaFerla Chapter 7. Hormonal Influences on Brain Aging and Age-Related Cognitive Decline Danielle K Lewis and Farida Sohrabji Chapter 8. Timing Deficits in Aging and Neuropathology Fuat Balci, Warren H. Meck, Holly Moor, and Dani Brunner

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Terms of Use.
  • - Barnes & reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)