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Animal Models of Human Inflammatory Skin Diseases

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Progress in understanding skin diseases has been aided enormously by the use of tissues derived from animals, by studying normal processes in animals, and by the development of animal models. The cellular activities in animals and humans are remarkably similar and the actual pathological process of an inflammatory skin disease can only be accurately observed and analyzed in a living animal model, and not in any in vitro model system. These factors have led to the regular use of animal tissues and models to allow ...

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Overview

Progress in understanding skin diseases has been aided enormously by the use of tissues derived from animals, by studying normal processes in animals, and by the development of animal models. The cellular activities in animals and humans are remarkably similar and the actual pathological process of an inflammatory skin disease can only be accurately observed and analyzed in a living animal model, and not in any in vitro model system. These factors have led to the regular use of animal tissues and models to allow the disease processes to be studied at a much greater depth.

Animal Models of Human Inflammatory Skin Diseases features the principles and practices of how to go about studying inflammatory skin diseases using live animal models. On the principle side, the book describes the comparative structure and function of the skin, and the comparative immunology system in animal species commonly used as models. From the practical perspective, it presents a general discussion on methods of experimental animal modeling and contains specific expert experience on individual models. The authors include a detailed method of disease induction for each model, present chapters on comparative histology and immunology, and discuss potential targets of disease intervention.

Written by biomedical investigators with first-hand experience in their chosen fields, this book is a valuable guide and reference for investigators in the biomedical and pharmaceutical sciences.
It provides an instantaneous comparison between the skin structure and immunology of humans and animals, aiding in the interpretation and application of pathologic and immunologic findings.

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Product Details

  • ISBN-13: 9780849313912
  • Publisher: Taylor & Francis
  • Publication date: 11/28/2003
  • Pages: 584
  • Product dimensions: 7.20 (w) x 10.30 (h) x 1.44 (d)

Table of Contents

PART I. COMPARATIVE STRUCTURE AND FUNCTION OF THE SKIN
Comparative Structure and Function of the Skin: Overview of Structures and Components
Comparative Structure and Function of the Skin: Epithelial Basement Membrane Zone
PART II. COMPARATIVE IMMUNOLOGY
Human Immune System
Canine Immune System
Rat Immune System
Mouse Immune System
PART III. IMMUNE PRIVILEGE AND SKIN INFLAMMATION
Immune Privilege of the Eye
Theory of Immune Privilege of the Hair Follicle
PART IV. METHODS OF EXPERIMENTAL ANIMAL MODELING
Passive Transfer and Active Induction of Autoimmune Diseases
Adoptive Transfer of Cellular Immunity
Molecular Biological Manipulation of the Immune System by Transgenic Techniques
PART V. INFLAMMATORY SKIN DISEASE MODELS
Section A. Bullous Pemphigoid
Natural Bullous Pemphigoid in Companion Animals
Experimental Mouse Model of Bullous Pemphigoid: Passive Transfer of Anti-type XVII Collagen Antibodies
Section B. Epidermolysis Bullosa Acquisita
Spontaneous Canine Model of Epidermolysis Bullosa Acquisita
Section C. Mucous Membrane Pemphigoid
Spontaneous Canine Model of Mucous Membrane Pemphigoid
Experimental Mouse Model of Mucous Membrane Pemphigoid: Passive Transfer of Anti-laminin 5 Antibodies
Section D. Pemphigus Vulgaris
Spontaneous Canine Model of Pemphigus Vulgaris
Experimental Mouse Model of Pemphigus Vulgaris: Passive Transfer of Desmoglein-targeting Antibodies
Experimental Mouse Model of Pemphigus Vulgaris: Passive Transfer of Nondesmoglein 1 & 3 Antibodies
Section E. Pemphigus Foliaceus
Spontaneous Canine Model of Pemphigus Foliaceus
Experimental Mouse Model of Pemphigus Foliaceus: Passive Transfer of Desmoglein-targeting Antibodies
Section F. Psoriasis
Experimental Chimeric SCID Mouse/Human Skin Model of Psoriasis: Induction by Transfer of Cellular Immunity
Experimental Mouse Model of Psoriasis by Transgenic Expression of Integrin
Section G. Atopic Dermatitis
Spontaneous Canine Model of Atopic Dermatitis
Spontaneous Mouse Model of Atopic Dermatitis in the NC/Nga Mice
Experimental Mouse Model of Atopic Dermatitis by Transgenic Expression of Cytokine
Experimental Mouse Model of Atopic Dermatitis: Induction by Oral Allergen
Experimental Mouse Model of Atopic Dermatitis: Induction by Epicutaneous Application of Allergen
Section H. Alopecia Areata
Spontaneous and Experimental Skin Graft Transfer Mouse Model of Alopecia Areata
Spontaneous Rat Model of Alopecia Areata in the Dundee Experimental Bald Rat (DEBR)
Spontaneous Canine Model of Alopecia Areata
Experimental Chimeric SCID Mouse/Human Skin Model of Alopecia Areata: Induction by Transfer of Cellular Immunity
Section I. Scleroderma
Spontaneous Mouse Model of Scleroderma
Experimental Mouse Model of Scleroderma/Graft vs. Host Disease: Induction by Transfer of Cellular Immunity
Experimental Mouse Model of Scleroderma: Induction by Bleomycin

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