Annals of the New York Academy of Sciences , Longevity Health Sciences: The Phoenix Conference / Edition 1

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Exciting papers by leading researchers are integrated in this volume with presentations having direct clinical relevance: thus, the latest scientific advances in aging research are coupled with reports on how these advances are being applied to longevity medicine.

Topics include oxidative stress, genetic/biochemical mechanisms, hormone therapy, nutrition, fitness, and exercise, all as they pertain to aging.

In exploring the links between the latest basic gerontological research and the practice of longevity medicine, the current challenges faced by both scientists and clinicians engaged in combating aging and its consequences are presented here. This volume is readily accessible to the educated reader who is interested in learning more about how to reduce the negative impact of aging on human health and longevity.

NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit

ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order ( Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit for more information about becoming a member.

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Table of Contents

Preface: Richard G. Cutler.

1. The Involvement of Thioredoxin and Thioredoxin Binding Protein-2 on Cellular Proliferation and Aging Process: Toru Yoshida, Hajime Nakamura, Hiroshi Masutani, and Junji Yodoi.

2. The Different Paths to Age One Hundred: Thomas Perls.

3. Genetic Engineering of Mice to Test the Oxidative Damage Theory of Aging: George M. Martin.

4. Aging and Genome Maintenance: Jan Vijg, Rita A. Busuttil, Rumana Bahar, and Martijn E.T. Dollé.

5. The Use of Genetic SNPs as New Diagnostic Markers in Preventive Medicine: Charles R. Cantor.

6. Longevity Determinant Genes: What is the Evidence? What's the Importance? Panel Discussion: Richard Cutler, L P Guarante, Thomas W. Kensler, Fred Naftolin, Dean P. Jones, Charles R. Cantor, and George M. Martin.

7. Decoding the Pyramid: A Systems-Biological Approach to Nutrigenomics: Jim Kaput.

8. Effects of Testosterone on Cognitive and Brain Aging in Elderly Men: Scott D. Moffat.

9. Oxidative Stress Profiling: Part I. Its Potential Importance in the Optimization of Human Health: Richard G. Cutler.

10. Oxidative Stress Profiling: Part II. Theory, Technology, and Practice: Richard G. Cutler, John Plummer, Kajal Chowdhury, and Christopher Heward.

11. Controversies in Dyslipidemias: Atheroprevention in Diabetes and Insulin Resistance: Eliot A. Brinton.

12. Dietary Fat and Health: The Evidence and the Politics of Prevention: Careful Use of Dietary Fats Can Improve Life and Prevent Disease: William E.M. Lands.

13. Physical Activity and Aging: Kerry J. Stewart.

14. Would Doubling the Human Lifespan Be a Net Positive or Negative for Us, Either as Individuals or as a Society? Point-Counterpoint: Gregory B. Stock and Daniel Callahan.



15. Regulatory Mechanisms Controlling Gene Expression Mediated by the Antioxidant Response Element: Thomas W. Kensler.

16. Targeting Redox Signaling Pathways for Anti-Inflammatory and Anti-Ischemic Drug Discovery: Guy Miller.

17. Mitochondrial Thioredoxin: Critical Protection for the Redox Throttle of Life: Dean P. Jones.

18. Regulation of Aging by SIR2: Leonard P. Guarante.

19. Androgens in the Aging Man: William J. Bremner.

20. Potential Adverse Effects of Administering Testosterone to Elderly Men: Peter J. Snyder.

21. Testosterone in Women: Adrian S. Dobs.

22. Estrogen: Metabolism, Actions and Effects: James W. Simpkins.

23. Estrogen and the Heart: Choices for Prevention of Coronary Vascular Disease: David M. Herrington.

24. Estrogen, Cognition, and Dementia: Sanjay Asthana.

25. Use of Growth Hormone for Prevention of Effects of Aging: S Mitchell Harman.

26. Cardiovascular Risk Assessment: Harvey S. Hecht.

Index of Contributors

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