BN.com Gift Guide

Annals of the New York Academy of Sciences, Skeletal Development and Remodeling in Health, Disease and Aging / Edition 1

Paperback (Print)
Buy New
Buy New from BN.com
$152.95
Used and New from Other Sellers
Used and New from Other Sellers
from $4.58
Usually ships in 1-2 business days
(Save 97%)
Other sellers (Paperback)
  • All (11) from $4.58   
  • New (5) from $23.00   
  • Used (6) from $4.58   

Overview

Our understanding of how the skeleton is remodeled and repaired has been enormously expanded in the past decade.

Using advanced molecular technologies including transgenesis, gene knockout, and gene array, we are gaining a better understanding of both the precise pathways through which osteoblasts lay down new bone and how osteoclasts remove old bone. These studies have not only helped us understand the basic biological properties of the skeleton and how it responds to hormonal, cytokine, and mechanical stimulation, but also, in some instances, clarified the source of pathophysiology.

The eventual goal of such discoveries is to lay down a firm scientific foundation for the identification of novel cellular and molecular targets for future drug development. This volume presents the significant headway that scientists have made in this undertaking and the book is organized around four broad themes: skeletal development and repair, molecular endocrinology of bone, bone cell biology, and conservation of skeletal integrity. Also included are papers that focus on current and emerging therapies for osteoporosis.

NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.

ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.

Read More Show Less

Product Details

Table of Contents

Part I: Skeletal Development:.

1. PTHrP and Skeletal Development: Henry Kronenberg.

2. Regulating Bone Growth with BMPs: Phoebe Leboy.

3. BMP and BMP Inhibitors in Bone: Vicki Rosen.

4. BMP Signaling and Skeletalogensis: Xu Cao.

5. Function of BMP and BMP Antagonist in Adult Bone: Etsuko Abe.

6. Dysregulation of the BMP4 Signaling Pathway in Fibrodysplasia Ossificans Progressiva: Frederick Kaplan.

7. Hypoxia, HIF-1Ą and VHL in Chondrogenesis: Ernestina Schipani.

8. Cellular and Molecular Mechanisms of Synovial Joint and Articular Cartilage Formation: Maurizio Pacifici.

9. Multiple Roles of Hoxc8 in Skeletal Development: Aster Juan et al.

Part II: Skeletal Remodeling:.

10. Osteoclasts and Integrins: Steven Teitelbaum.

11. Regulation of Osteoclast Differentiation: David Roodman.

12. Signaling in Osteoclast and their Precursors: Patrick Ross.

13. Canonical Wnt Signaling in Osteoblasts is Required for Osteoclast Differentiation: Gerard Karsenty.

14. Inhibition of ATF4 Transcriptional Activity by TIAT/ƒ×-Taxilin Modulates Bone Mass: Rene St. Arnaud.

15. Paget's Disease of Bone and Genetic Disorders of RANK/OPG/RANK/NF-ƒÛB signaling: Michael Whyte.

16. The Regulation of Cathepsin K Gene Expression: Bruce Troen.

17. Direct and Indirect Estrogen Actions on Osteoblasts and Osteoclasts: Alberta Zallone.

18. Molecular Mechanism of the Life and Death of the Osteoclast: Sakae Tanaka.

19. Understanding Parathyroid Hormone Action: Nicola Partridge.

20. New Insights Into the Mechanisms Involved in The Pleiotropic Actions of 1,25dihydroxyvitamin D3: Sylvia Christakos.

21. Mechanisms of Vitamin D Receptor Action: Marie Demay.

22. Role of Connexin 43 in Osteoblast Response to Physical Load: Roberto Civitelli.

23. Interactive Effect of Interleukin-6 and Prostaglandin E2 on Osteoclastogenesis via the OPG/RANK-L/RANK System: Xin-Hua Liu.

24. Does TNF Have Anti-Osteoclastogenic Actions?: Jameel Iqbal.

25. Eosinophil Chemotactic Factor-L (ECF-L) Enhances Osteoclast Formation by Increasing ICAM-1 Expression: Garcia Palacios and David Roodman.

Part III: Mechanisms Of Bone Loss:.

26. Bone Cell Precursors and the Pathophysiology of Bone Loss: Harry Blair and Jill Carrington.

27. Autosomal Dominant Pseudohypoparathyroidism Type 1b is Caused by Different Microdeletions Within or Upstream of the GNAS Locus: Harold Jueppner.

28. Estrogen Regulation of Immune Cells Bone Interactions: Roberto Pacifici.

29. Autoimmunity and Bone: Edward Schwarz.

30. Non-Steroid Immune Modulators and Bone Disease: Solomon Epstein.

31. Pathogenesis of Osteopenia/Osteoporosis Induced by Highly Active Anti-Retroviral Therapy for AIDS: Jay McDonald.

32. Pituitary Hormones and Bone Loss: Mone Zaidi.

33. Bone Destruction in Multiple Myeloma: Toshio Matsumoto.

34. Osteogenic Regulation of Vascular Calcification: Dwight Towler.

35. The OPG/TRAIL Complex in an In Vitro Osteoclastogenesis Model Dervied From Human Multiple Myeloma Bone Disease: Maria Grano et al.

36. Restoration of Bone Mass in hpg Mouse by Preoptic Area Grafting: Gopalan Rajendren.

37. IL-7 Drives T Cell-Medicated Bone Loss Following Ovariectomy: Michaela Robbie-Ryan and M. Neale Weitzmann.

Part IV: Restoring Skeletal Strength:.

38. Stem Cells and Tissue Engineering: Past, Present and Future: Julia Polak.

39. Bisphosphonates: From Bench to Bedside: Graham Russell.

40. Novel Targets and Therapeutics for Bone Loss: Ronald N. Margolis and Sunil J. Wimalawansa.

41. Advanced Imaging Assessment of Bone Quality: Harry Genant.

42. Bone Strength: Current Concepts: Charles Turner.

43. Anti-Catabolic Therapeutic Target in Bone Disease: Brendan Boyce.

44. Mechanisms Involved in Skeleton Anabolic Therapies: Jack Martin.

45. Misconceptions About Calcimimetics: Edward Nemeth.

46. Osteoblastic Activation in the Hematopoetic Stem Cell Niche: Laura Calvi.

47. Circulating Cells with Osteogenic Potential: Sundeep Khosla.

48. The Pericellular Matrix as a Transducer of Biomechanical Signals in Auricular Cartilage: Farshid Guilak.

49. Clinical Biophysics: The Promotion of Skeletal Repair by Physical Force: Roy Aaron.

50. COX-2 has a Critical Role During Incorporation of Structural Bone Allografts: Regis O'Keefe.

51. The Effect of Anti-TNF Therapy on Spinal Bone Mineral Density in Crohn¡¦s Disease: Michael Pazianas.

52. Bone Remodeling in Health and Disease: Lessons from Mathematical Modeling: Svetlana V Komarova.

53. Modeling of Serum C-Telopeptide Levels with Daily and Monthly Oral Ibandronate: Mone Zaidi.

54. NFATc1: A Novel Anabolic Therapeutic Target for Osteoporosis: Majd Zayzafoon.

55. Mechanical Loading Differentially Regulates Membrane Bound and Soluble RANKL Availability in MC3T3-E1 Cells: Dae Won Kim and Francis Y. Lee.

Index of Contributors

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)