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More About This Textbook
Overview
This brand new Annual Plant Reviews volume is the second edition of the highly successful and well-received Functions of Plant Secondary Metabolites and their Exploitation in Biotechnology (Annual Plant Reviews, Volume 3).
This exciting new volume provides an up-to-date survey of the functions of plant secondary metabolites, their modes of action and their use in pharmacology as molecular probes, in medicine as therapeutic agents, and in agriculture as biorational pesticides. The possibilities to produce valuable natural products in plant cell and tissue culture and even in recombinant microorganisms are also reviewed.
This carefully compiled new edition brings together chapters from some of the world's leading experts in plant secondary metabolites. Completely revised and brought right up to date with much new information, this volume is an essential purchase for advanced students, researchers and professionals in biochemistry, physiology, molecular biology, genetics, plant sciences, agriculture, medicine, pharmacology and pharmacy, working in the academic and industrial sectors, including those working in the pesticide and pharmaceutical industries. Libraries in all universities and research establishments where these subjects are studied and taught will need copies of this excellent volume on their shelves.
A companion volume, Annual Plant Reviews Volume 40, Biochemistry of Plant Secondary Metabolism, Second Edition, Edited by M. Wink, is also available.
Product Details
Meet the Author
Table of Contents
List of contributors ix
Preface xi
1 Introduction Michael Wink 1
1.1 Ecological function of secondary metabolites 1
1.2 Presence of defence and signal compounds at the right time and place 4
1.3 Molecular modes of action of SM 8
1.4 Biotechnology and utilization of SM 13
1.5 Conclusions 16
2 Molecular Modes of Action of Defensive Secondary Metabolites Michael Wink Oskar Schimmer 21
2.1 Introduction 21
2.2 Molecular modes of action - an overview 22
2.3 Accumulation of defence and signal compounds in plants 128
2.4 Animal responses: detoxification mechanisms and adaptations 132
2.5 Concluding remarks 137
3 Chemical Defence in Marine Ecosystems Annika Putz Peter Proksch 162
3.1 Introduction 162
3.2 Marine natural products in allelopathic interactions 165
3.3 Chemical defence against fouling 168
3.4 Chemical defences of marine invertebrates and algae against consumers 173
3.5 Favoured allocation of defensive metabolites in vulnerable and valuable parts of marine invertebrates and algae 182
3.6 The flexible response: stress-induced accumulation of defence metabolites and activation of protoxins 186
3.7 Endosymbionts as sources for allelochemicals found in marine invertebrates 193
3.8 Conclusions and outlook 201
4 Plant-Microbe Interactions and Secondary Metabolites with Antibacterial, Antifungal and Antiviral Properties Jürgen Reichling 214
4.1 Introduction 215
4.2 Phytoalexins 217
4.3 Antibacterial and antifungal agents of higher plants 232
4.4 Secondary metabolities from higher plants with antiviral properties 278
4.5 Conclusions 317
5 New Medical Applications of Plant Secondary Metabolites Jörg Heilmann 348
5.1 Introduction 349
5.2 Compounds with anticancer and chemopreventive activity 349
5.3 Antiviral compounds 359
5.4 Antimalarial drugs 360
5.5 Anti-inflammatory drugs 361
5.6 Antidepressant drugs 363
5.7 Anti-ischaemic drugs 364
5.8 Immunostimulatory drugs 365
5.9 Conclusions 366
6 Production of Natural Products by Plant Cell and Organ Cultures August-Wilhelm Alfermann 381
6.1 Introduction 381
6.2 Production of natural products by cell and organ cultures 383
6.3 Elicitation 383
6.4 Increase/decrease of product yields by genetic manipulation 384
6.5 Biosynthetic pathways delineation using RNA-interference 385
6.6 Mass cultivation of plant cell cultures 386
6.7 Production of recombinant proteins by plants and plant cell cultures 388
6.8 Production of plant natural products in microbes 389
6.9 Perspectives 390
Index 399