Annual Review of Biophysics and Biomolecular Structure / Edition 1

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Editorial Reviews

Anatoly Bezkorovainy
This is the 24th volume in an annual review series of biophysics and structural biochemistry, especially as these pertain to proteins and nucleic acids, and to some extent, membranes. It is a must for any library serving scientists who conduct research or teach in any of the basic biomedical fields. The purpose is to document developments in various biophysical and biostructural topics that have shown considerable degrees of progress in recent years. Articles in this volume are aimed at experts in the field, though the book is also useful for the general biomedical scientific audience and graduate students. The book is modestly illustrated, the extent and sophistication of illustrations depending on individual articles. Table of contents and index are adequate, and references are plentiful and current. As in previous volumes, the vita of a noted contributor to the area of biophysics and/or biostructure is a welcome touch, in this case that of Dr. Ephraim Katchalski-Katzir. The overall appearance of the book is, or should be, irrelevant for this most recent addition to a well-known and well-received Annual Reviews series. Nevertheless, an effort has been made to make it attractive. The review articles, written by recognized experts in their respective fields, are, as usual, of the highest caliber and sophistication. The general reader would appreciate the background material that most, but not all, articles contain to put the topics discussed in the proper perspective. For instance, the article on calmodulin contains an introduction describing the function of this protein in the second messenger system, which is then followed by the main body of the article on its structuralcharacteristics. On the other hand, the article on colicins simply states that they are bacteriocins without explaining what bacteriocins are. If one is not a lactic acid bacteria expert, chances are that this term would not be familiar. This is an excellent volume with a wealth of information on many subjects of current interest.
Eugene A. Davidson
This volume is divided into four sections -- Structural Principles, Structure and Function, Dynamics, and Emerging Techniques. This book is the latest in a continuing series that provides current reviews in selected areas of structural biology. It will be a useful reference for those working in the area of structural biology. Three articles focus on structural analyses. Included are X-ray analyses of four RNA folds (tRNA, hammerhead ribozyme, the P4-P6 domain of the Tetrahymena group I intron, and the hepatitis delta virus ribozyme). This is followed by a discussion of complex oligosaccharide conformation and interaction of these structures with proteins studied by both NMR and X-ray methods and the physical principles governing the folding of membrane proteins. In subsequent chapters contributors discuss transcriptional regulation, DNA repair mechanisms (recognition and removal of altered bases), lysosomal cysteine proteases, the 26s proteasome, and the structure of bacteriorhodopsin. Physical and computational means of structure determination are emphasized in all of the reviews and will be of interest to scientists concerned with these problems. The volume concludes with a short section on problems not approachable by standard methods, including computer simulations and solid state NMR. The increasing use of physical methods to study large structures such as the ribosome and membrane-associated biomolecules is providing new insight into the architecture of macromolecular complexes.
From The Critics
This collection of 19 contributions describes recent progress in the application of physics to the study of biomolecular structures. The authors present new developments in analyzing the atomic structure of ribosomes, the crystal structure of rhodopsin, the regulation of integrins, protein transmembrane channels, and DNA-protein interactions. Other topics include a thermodynamic perspective of T cell signaling, computer modeling of cellular systems, lanthanide chelates as fluorescent labels, and paramagnetic resonance of biological metal centers. Annotation c. Book News, Inc., Portland, OR (booknews.com)
Booknews
Representing the current state of research concerning numerous problems in quantitative biology, 21 papers discuss topics including: hydrogen bonding, base stacking, and steric effects in DNA; structures and proton-pumping strategies of mitochondrial respiratory enzymes; mass spectrometry; Cre- site-specific recombination; NMR probes of molecular dynamics; ab inito protein structure prediction; structural relationships among phosphorylses; biomolecular simulations; protein folding; binding of ligands and activation of transcription by nuclear receptors; microtubule function; and ribozyme structures and mechanisms. Annotation c. Book News, Inc., Portland, OR (booknews.com)
Doody's Review Service
Reviewer: Eugene A Davidson, PhD (Georgetown University School of Medicine)
Description: This volume is divided into four sections — Structural Principles, Structure and Function, Dynamics, and Emerging Techniques.
Purpose: This book is the latest in a continuing series that provides current reviews in selected areas of structural biology.
Audience: It will be a useful reference for those working in the area of structural biology.
Features: Three articles focus on structural analyses. Included are X-ray analyses of four RNA folds (tRNA, hammerhead ribozyme, the P4-P6 domain of the Tetrahymena group I intron, and the hepatitis delta virus ribozyme). This is followed by a discussion of complex oligosaccharide conformation and interaction of these structures with proteins studied by both NMR and X-ray methods and the physical principles governing the folding of membrane proteins. In subsequent chapters contributors discuss transcriptional regulation, DNA repair mechanisms (recognition and removal of altered bases), lysosomal cysteine proteases, the 26s proteasome, and the structure of bacteriorhodopsin. Physical and computational means of structure determination are emphasized in all of the reviews and will be of interest to scientists concerned with these problems. The volume concludes with a short section on problems not approachable by standard methods, including computer simulations and solid state NMR.
Assessment: The increasing use of physical methods to study large structures such as the ribosome and membrane-associated biomolecules is providing new insight into the architecture of macromolecular complexes.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780824318239
  • Publisher: Annual Reviews, Incorporated
  • Publication date: 1/1/1994
  • Edition number: 1
  • Pages: 895

Table of Contents

Measuring the Forces That Control Protein Interactions 1
Structure and Function of Lipid-DNA Complexes for Gene Delivery 27
Signaling and Subcellular Targeting by Membrane Binding Domains 49
GCN5-Related N-Acetyltransferases: A Structural Overview 81
Structural Symmetry and Protein Function 105
Electrokinetically Controlled Microfluidic Analysis Systems 155
DNA Recognition by Cys[subscript 2]His[subscript 2] Zinc Finger Proteins 183
Protein Folding Intermediates and Pathways Studied by Hydrogen Exchange 213
Quantitative Chemical Analysis of Single Cells 239
The Structural Biology of Molecular Recognition by Vancomycin 265
Comparative Protein Structure Modeling of Genes and Genomes 291
Fast Kinetics and Mechanisms in Protein Folding 327
Atomic Force Microscopy in the Study of Macromolecular Crystal Growth 361
A Decade of CLC Chloride Channels: Structure, Mechanism, and Many Unsettled Questions 411
Designed Sequence-Specific Minor Groove Ligands 439
Publsed and Parallel-Polarization EPR Characterization of the Photosystem II Oxygen-Evolving Complex 463
Electrostatic Mechanisms of DNA Deformation 497
Stress-Induced Structural Transitions in DNA and Proteins 523
Molecular Mechanisms Controlling Actin Filament Dynamics in Nonmuscle Cells 545
Unnatural Ligands for Engineered Proteins: New Tools for Chemical Genetics 577
Indexes
Subject Index 607
Cumulative Index of Contributing Authors, Volumes 25-29 633
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