Antiarrhythmic Drugs: Mechanisms of Antiarrhythmic and Proarrhythmic Actions / Edition 1

Antiarrhythmic Drugs: Mechanisms of Antiarrhythmic and Proarrhythmic Actions / Edition 1

by G?nter Breithardt
     
 

ISBN-10: 3540592547

ISBN-13: 9783540592549

Pub. Date: 01/28/1995

Publisher: Springer Berlin Heidelberg

The objective of this book is to focus on new strategies of antiarrhythmic drug treatment and to reconsider the basic mechanisms by which antiarrhythmic drugs might suppress or facilitate cardiac arrhythmias. About 30 well-recognised scientists from Europe and the United States have written condensed review articles on the following topics: basic mechanisms of

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Overview

The objective of this book is to focus on new strategies of antiarrhythmic drug treatment and to reconsider the basic mechanisms by which antiarrhythmic drugs might suppress or facilitate cardiac arrhythmias. About 30 well-recognised scientists from Europe and the United States have written condensed review articles on the following topics: basic mechanisms of antiarrhythmic drug action, modulation of antiarrhythmic drug action by disease and injury, pharmacological interactions, variability of the arrhythmogenic substrate, and "novel" antiarrhythmic drugs.

Product Details

ISBN-13:
9783540592549
Publisher:
Springer Berlin Heidelberg
Publication date:
01/28/1995
Edition description:
New Edition
Pages:
410
Product dimensions:
6.10(w) x 9.25(h) x (d)

Related Subjects

Table of Contents

Sodium Channel Blockade as an Antiarrhythmic Mechanism3
Pharmacology of T and L type Ca[superscript 2+] Channels in Cardiac Tissue23
Molecular Biology and Ion Channel Biophysics: Their Role in Rational Pharmacological Antiarrhythmic Therapy35
Selective Pharmacological Modification of Repolarizing Currents: Antiarrhythmic and Proarrhythmic Actions of Agents that Influence Repolarization of the Heart57
A Shift from Class to Class III Drugs in the Medical Treatment of Arrhythmias: Wishful Thinking?81
Use Dependence and Reverse Use Dependence of Antiarrhythmic Agents: Pro- and Antiarrhythmic Actions92
Interaction of Transient Ischemia with Antiarrhythmic Drugs109
Management of Patients with Sustained Ventricular Tachyarrhythmias: Different Clinical Studies, Different Patients122
Antiarrhythmic Drug Action: Modulation by Disease and Injury144
Pharmacological Modulation of Reentrant Excitation in Experimental Models173
Reentry in Clinical Arrhythmias: Mechanisms Responsible for Antiarrhythmic Drug Efficacy192
Experimental Models for the Assessment of Antiarrhythmic and Proarrhythmic Drug Action: Traditional and Newer Models207
Influence of the Autonomic Nervous System on the Action of Antiarrhythmic Drugs240
Role of Drugs in Torsade de Pointes and Triggered Activity
The Study of Pharmacokinetics and Pharmacodynamics as a Tool for Understanding Mechanisms of Antiarrhythmic Drug Action290
Electrophysiologic Effects, Clinical Efficacy and Antiarrhythmic and Proarrhythmic Effects of Sodium Channel Blockers in Patients with Ventricular Tachyarrhythmias300
Antiarrhythmic Versus Proarrhythmic Effects of Class III Agents321
Electrophysiologic Properties and Antiarrhythmic Effects of Adenosine and Adenosine Triphosphate335
Magnesium-Electrophysiological Effects, Antiarrhythmic Properties and Clinical Applications363
The Classification of Antiarrhythmic Drugs: How do we Educate the Scientist and the Clinician?393
Subject Index405

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