Antiarrhythmic Drugs: Mechanisms of Antiarrhythmic and Proarrhythmic Actions / Edition 1

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The objective of this book is to focus on new strategies of antiarrhythmic drug treatment and to reconsider the basic mechanisms by which antiarrhythmic drugs might suppress or facilitate cardiac arrhythmias. About 30 well-recognised scientists from Europe and the United States have written condensed review articles on the following topics: basic mechanisms of antiarrhythmic drug action, modulation of antiarrhythmic drug action by disease and injury, pharmacological interactions, variability of the arrhythmogenic substrate, and "novel" antiarrhythmic drugs.

Modulation of antiarrhythmic drug action by disease, injury/ reentrant excitation: pharmacological interactions/etc.

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Editorial Reviews

Doody's Review Service
Reviewer: Renzo Cataldo, MD (Loyola University Stritch School of Medicine)
Description: This first edition book is intended to shed new light on old concepts of antiarrhythmic drugs. Although this is not a comprehensive review of each drug in detail, it ties in much of the modern topics.
Purpose: The purpose is to reevaluate old classifications of antiarrhythmic drugs at a basic and a clinical level. These objectives are worthy, considering the results of large clinical trials that have changed clinical practice. The authors have provided interesting insight on antiarrhythmic drug therapy in 1995.
Audience: This book is targeted at the cardiac electrophysiologist (clinical and nonclinical). It could be read by a general cardiologist; however, some concepts may be foreign and quite complex. The book is not written for students, trainees, or internists. The authors are quite credible authorities.
Features: The illustrations are adequate, especially the basic science illustrations. Clinical illustrations are somewhat underrepresented. The illustrations are reasonably well annotated and clear. There is no need for color illustrations for this topic. The book is not intended for a general audience, and therefore, general topics of antiarrhythmic drugs, such as side effect profiles, or cost profiles, practical issues for the clinician, are not covered in detail.
Assessment: This book offers excellent insights into the basic concepts of antiarrhythmic drug therapy, especially on a basic level. It reviews information that is not necessarily practical for the clinician in internal medicine or even in general cardiology. Because its targeted audience is relatively small, the usefulness of the book is dependent on the population encountered at the bookstore. It is probably useful for a complete and large medical library of a large medical center.
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Product Details

  • ISBN-13: 9783540592549
  • Publisher: Springer Berlin Heidelberg
  • Publication date: 1/28/1995
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 410

Table of Contents

Sodium Channel Blockade as an Antiarrhythmic Mechanism 3
Pharmacology of T and L type Ca[superscript 2+] Channels in Cardiac Tissue 23
Molecular Biology and Ion Channel Biophysics: Their Role in Rational Pharmacological Antiarrhythmic Therapy 35
Selective Pharmacological Modification of Repolarizing Currents: Antiarrhythmic and Proarrhythmic Actions of Agents that Influence Repolarization of the Heart 57
A Shift from Class to Class III Drugs in the Medical Treatment of Arrhythmias: Wishful Thinking? 81
Use Dependence and Reverse Use Dependence of Antiarrhythmic Agents: Pro- and Antiarrhythmic Actions 92
Interaction of Transient Ischemia with Antiarrhythmic Drugs 109
Management of Patients with Sustained Ventricular Tachyarrhythmias: Different Clinical Studies, Different Patients 122
Antiarrhythmic Drug Action: Modulation by Disease and Injury 144
Pharmacological Modulation of Reentrant Excitation in Experimental Models 173
Reentry in Clinical Arrhythmias: Mechanisms Responsible for Antiarrhythmic Drug Efficacy 192
Experimental Models for the Assessment of Antiarrhythmic and Proarrhythmic Drug Action: Traditional and Newer Models 207
Influence of the Autonomic Nervous System on the Action of Antiarrhythmic Drugs 240
Role of Drugs in Torsade de Pointes and Triggered Activity
The Study of Pharmacokinetics and Pharmacodynamics as a Tool for Understanding Mechanisms of Antiarrhythmic Drug Action 290
Electrophysiologic Effects, Clinical Efficacy and Antiarrhythmic and Proarrhythmic Effects of Sodium Channel Blockers in Patients with Ventricular Tachyarrhythmias 300
Antiarrhythmic Versus Proarrhythmic Effects of Class III Agents 321
Electrophysiologic Properties and Antiarrhythmic Effects of Adenosine and Adenosine Triphosphate 335
Magnesium-Electrophysiological Effects, Antiarrhythmic Properties and Clinical Applications 363
The Classification of Antiarrhythmic Drugs: How do we Educate the Scientist and the Clinician? 393
Subject Index 405
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