Antibiotic Resistance: Origins, Evolution, Selection and Spread

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Antibiotic Resistance: Origins, Evolution, Selection and Spread Chairman: Stuart B. Levy 1997 Over the last 50 years, the rapid increase in the use of antibiotics, not only in people, but also in animal husbandry and agriculture, has delivered a selection unprecedented in the history of evolution. Consequently, society is facing one of its gravest public health problems-the emergence of infectious bacteria with resistance to many, and in some cases all, available antibiotics. This book brings together a ...
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1997 This is an ex-library book and may have the usual library/used-book markings inside. This book has hardback covers. In fair condition, suitable as a study copy., 650grams, ... ISBN: 9780471971054. *****PLEASE NOTE: This item is shipping from an authorized seller in Europe. In the event that a return is necessary, you will be able to return your item within the US. To learn more about our European sellers and policies see the BookQuest FAQ section***** Read more Show Less

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Overview

Antibiotic Resistance: Origins, Evolution, Selection and Spread Chairman: Stuart B. Levy 1997 Over the last 50 years, the rapid increase in the use of antibiotics, not only in people, but also in animal husbandry and agriculture, has delivered a selection unprecedented in the history of evolution. Consequently, society is facing one of its gravest public health problems-the emergence of infectious bacteria with resistance to many, and in some cases all, available antibiotics. This book brings together a multidisciplinary group of experts to discuss this problem. It begins by examining the origins of resistance and goes on to look at how the use of antibiotics in human medicine and farming/agriculture has selected for resistant bacteria. Separate chapters describe the evolution of resistance determinants and how these are spread both within and between bacterial species. Finally, the book contains discussions on strategies for countering the threat of antibiotic resistance. A major re-thinking of our approach to the treatment of infectious diseases is proposed-that antibiotic resistance should be seen as a problem created by the disruption of normal microbial ecology. To restore efficacy to earlier antibiotics, and to maintain the success of new antibiotics that are introduced, we need to use these drugs in a way that ensures an ecological balance that favours the predominance of susceptible bacteria.
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Editorial Reviews

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Proceedings of the July 1996 symposium addressing the grave public health problem of the emergence of infectious bacteria with resistance to many, and in some cases all, available antibiotics. Fifteen contributions address topics such as the relationship between erythromycin consumption and resistance in Finland, the impact of antibiotic use in animal feeding on resistance of bacterial pathogens in humans, the cost of antibiotic resistance, and epidemiological factors influencing the emergence of antimicrobial resistance. Annotation c. by Book News, Inc., Portland, Or.
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Product Details

  • ISBN-13: 9780471971054
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 5/28/1997
  • Series: Novartis Foundation Symposia Series , #132
  • Edition number: 1
  • Pages: 260
  • Product dimensions: 6.34 (w) x 9.65 (h) x 0.87 (d)

Table of Contents

Antibiotic resistance: an ecological imbalance 1
Origins, acquisition and dissemination of antibiotic resistance determinants 15
The relationship between erythromycin consumption and resistance in Finland 36
The contribution of antibiotic use on the frequency of antibiotic resistance in hospitals 47
Impact of antibiotic use in animal feeding on resistance of bacterial pathogens in humans 61
The effect of monitoring of antibiotic use on decreasing antibiotic resistance in the hospital 76
The antibiotic selective process: concentration-specific amplification of low-level resistant populations 93
The within-host population dynamics of antibacterial chemotherapy: conditions for the evolution of resistance 112
The cost of antibiotic resistance - from the perspective of a bacterium 131
The evolution of [beta]-lactamases 152
Molecular evolution of multiply-antibiotic-resistant staphylococci 167
Mobile gene cassettes and integrons: moving antibiotic resistance gene in Gram-negative bacteria 192
Genetic mobility and distribution of tetracycline resistance determinants 206
Epidemiological factors influencing the emergence of antimicrobial resistance 223
Summary 238
Index of contributors 240
Subject index 242
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