Antibiotic Resistance: Understanding and Responding to an Emerging Crisis

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Overview

The emergence and spread of antibiotic resistance is a growing medical and public health emergency. Misuse and overuse of antibiotics is putting us at risk of losing our ability to cure infectious diseases. Karl Drlica and David S. Perlin give an authoritative and thorough explanation of all aspects of antibiotic resistance, from the basic science to the strategies that could minimize resistance problems and extend the life spans of existing antibiotic agents. Intended as the definitive book on a major biomedical issue, Antibiotic Resistance will be required reading for investigators and serious students in microbiology, infectious disease, pharmaceutics, and public health; physicians; and students in pharmacy, medicine, and veterinary medicine.

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Product Details

  • ISBN-13: 9780131387737
  • Publisher: FT Press
  • Publication date: 2/23/2011
  • Pages: 288
  • Product dimensions: 6.90 (w) x 10.00 (h) x 0.90 (d)

Meet the Author

Karl Drlica, Ph.D. is a Principal Investigator at the Public Health Research Institute and Professor of Microbiology & Molecular Genetics at the UMDNJ–New Jersey Medical School in Newark. His laboratory focuses on fluoroquinolone action and resistance with Mycobacteriun tuberculosis and other bacteria, including approaches for slowing the enrichment and amplification of resistant bacterial subpopulations.

David S. Perlin, Ph.D. is Executive Director of the Public Health Research Institute and UMDNJ Regional Biocontainment Laboratory, as well as Professor of Microbiology & Molecular Genetics at the New Jersey Medical School in Newark. He is also a Fellow of the New York Academy of Sciences. Dr. Perlin’s laboratory explores mechanisms of antifungal drug-resistance, rapid detection of drug resistant bloodstream pathogens in high-risk patients, and the application of small-animal models for the study of respiratory pathogens.

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Table of Contents

Preface xv

Chapter 1 Introduction to the Resistance Problem 1

Chapter 2 Working with Pathogens 17

Chapter 3 A Survey of Antibiotics 31

Chapter 4 Dosing to Cure 55

Chapter 5 Emergence of Resistance 73

Chapter 6 Movement of Resistance Genes Among Pathogens 91

Chapter 7 Transmission of Resistant Disease 105

Chapter 8 Surveillance 125

Chapter 9 Making New Antibiotics 139

Chapter 10 Restricting Antibiotic Use and Optimizing Dosing 149

Chapter 11 Influenza and Antibiotic Resistance 167

Chapter 12 Avoiding Resistant Pathogens 177

Afterword A Course of Action 203

Appendix A Molecules of Life 207

Appendix B Microbial Life Forms 221

Glossary 227

Literature Cited 233

Index 251

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