Antibiotics: Actions, Origins, Resistance / Edition 1

Antibiotics: Actions, Origins, Resistance / Edition 1

by Christopher Walsh
     
 

ISBN-10: 1555812546

ISBN-13: 9781555812546

Pub. Date: 02/28/2003

Publisher: ASM Press

Walsh (Harvard Medical School) focuses on natural products with antibiotic activity elaborated by microbes to act as chemical weapons on neighboring bacteria, especially those few structural classes of molecules that have been reported to have had an impact in human infectious diseases. His basic premise is that the action of antibiotics can be understood and

Overview

Walsh (Harvard Medical School) focuses on natural products with antibiotic activity elaborated by microbes to act as chemical weapons on neighboring bacteria, especially those few structural classes of molecules that have been reported to have had an impact in human infectious diseases. His basic premise is that the action of antibiotics can be understood and categorized, both historically and prospectively, by analyzing how these small molecules interfere selectively with one or more processes central to the survival of bacterial cells. He considers how antibiotics block specific proteins, how the molecular structure of drugs enables such activity, the development of bacterial resistance, the molecular logic of antibiotic biosynthesis, and prospects for broadening the target base. Annotation (c)2003 Book News, Inc., Portland, OR

Product Details

ISBN-13:
9781555812546
Publisher:
ASM Press
Publication date:
02/28/2003
Edition description:
New Edition
Pages:
345
Product dimensions:
7.10(w) x 10.10(h) x 0.90(d)

Table of Contents

Table of Contents

Section I. Introduction to Antibiotics
Antibiotics: Initial Concepts

Section II. Validated Targets and Major Antibiotic Classes

Introduction to Major Antibiotic Classes and Modes of Action
Antibiotics That Act on Cell Wall Biosynthesis
Antibiotics That Block Bacterial Protein Biosynthesis
Antibiotics That Block DNA Replication and Repair: the Quinolones
Other Targets of Antibacterial Drugs

Section III. Antibiotic Resistance

Natural and Producer Immunity versus Acquired Resistance
Enzymatic Destruction or Modification of the Antibiotic by Resistant Bacteria
Antibiotic Resistance by Efflux Pumps
Antibiotic Resistance by Replacement or Modification of the Antibiotic Target

Section IV. Antibiotic Biosynthesis

Regulation of Antibiotic Biosynthesis in Producer Organisms
Polyketide Antibiotic Biosynthesis: Assembly-Line Enzymology
Enzymatic Assembly Lines for Nonribosomal Peptide Antibiotics
Biosynthesis of Other Classes of Antibiotics

Section V. New Strategies for Finding Novel Antibiotics and Extending Their Lifetimes

New Looks at Targets
New Molecules
Contexts and Challenges for the Use of New Antibiotics

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