Antibiotics: Actions, Origins, Resistance / Edition 1

Antibiotics: Actions, Origins, Resistance / Edition 1

by Christopher Walsh
     
 

ISBN-10: 1555812546

ISBN-13: 9781555812546

Pub. Date: 02/28/2003

Publisher: ASM Press

Walsh (Harvard Medical School) focuses on natural products with antibiotic activity elaborated by microbes to act as chemical weapons on neighboring bacteria, especially those few structural classes of molecules that have been reported to have had an impact in human infectious diseases. His basic premise is that the action of antibiotics can be understood and…  See more details below

Overview

Walsh (Harvard Medical School) focuses on natural products with antibiotic activity elaborated by microbes to act as chemical weapons on neighboring bacteria, especially those few structural classes of molecules that have been reported to have had an impact in human infectious diseases. His basic premise is that the action of antibiotics can be understood and categorized, both historically and prospectively, by analyzing how these small molecules interfere selectively with one or more processes central to the survival of bacterial cells. He considers how antibiotics block specific proteins, how the molecular structure of drugs enables such activity, the development of bacterial resistance, the molecular logic of antibiotic biosynthesis, and prospects for broadening the target base. Annotation (c)2003 Book News, Inc., Portland, OR

Product Details

ISBN-13:
9781555812546
Publisher:
ASM Press
Publication date:
02/28/2003
Edition description:
New Edition
Pages:
345
Product dimensions:
7.10(w) x 10.10(h) x 0.90(d)

Table of Contents

Preface
Sect. IIntroduction to Antibiotics1
Ch. 1Antibiotics: Initial Concepts3
Sect. IIValidated Targets and Major Antibiotic Classes11
Ch. 2Introduction to Major Antibiotic Classes and Modes of Action13
Ch. 3Antibiotics That Act on Cell Wall Biosynthesis23
Ch. 4Antibiotics That Block Bacterial Protein Biosynthesis51
Ch. 5Antibiotics That Block DNA Replication and Repair: the Quinolones71
Ch. 6Other Targets of Antibacterial Drugs79
Sect. IIIAntibiotic Resistance89
Ch. 7Natural and Producer Immunity versus Acquired Resistance91
Ch. 8Enzymatic Destruction or Modification of the Antibiotic by Resistant Bacteria107
Ch. 9Antibiotic Resistance by Efflux Pumps125
Ch. 10Antibiotic Resistance by Replacement or Modification of the Antibiotic Target143
Sect. IVAntibiotic Biosynthesis157
Ch. 11Regulation of Antibiotic Biosynthesis in Producer Organisms159
Ch. 12Polyketide Antibiotic Biosynthesis: Assembly-Line Enzymology175
Ch. 13Enzymatic Assembly Lines for Nonribosomal Peptide Antibiotics195
Ch. 14Biosynthesis of Other Classes of Antibiotics221
Sect. VNew Strategies for Finding Novel Antibiotics and Extending Their Lifetimes235
Ch. 15New Looks at Targets237
Ch. 16New Molecules271
Ch. 17Contexts and Challenges for the Use of New Antibiotics285
References297
Index329

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