Antibiotics: Actions, Origins, Resistance / Edition 1

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A comprehensive account of the structural classes of antibiotics that have impacted human infectious disease.
• Provides an introduction to antibiotics and examines how antibiotics block specific proteins acting in essential bacterial processes and how the molecular structure of the small-molecule drugs enables their antibiotic activity.
• Explores the development of bacterial resistance to antibiotics, including the molecular logic that microbial producers of antibiotics use for self-protection.
• Addresses the molecular logic of antibiotic biosynthesis, starting with regulatory networks that control gene transcription of secondary metabolites in streptomycetes, and examines the prospects for broadening the base of bacterial targets and also where new antibiotics are likely to emerge, including both synthetic chemical efforts and natural products.
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Product Details

  • ISBN-13: 9781555812546
  • Publisher: ASM Press
  • Publication date: 2/28/2003
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 345
  • Product dimensions: 7.10 (w) x 10.10 (h) x 0.90 (d)

Table of Contents

Sect. I Introduction to Antibiotics 1
Ch. 1 Antibiotics: Initial Concepts 3
Sect. II Validated Targets and Major Antibiotic Classes 11
Ch. 2 Introduction to Major Antibiotic Classes and Modes of Action 13
Ch. 3 Antibiotics That Act on Cell Wall Biosynthesis 23
Ch. 4 Antibiotics That Block Bacterial Protein Biosynthesis 51
Ch. 5 Antibiotics That Block DNA Replication and Repair: the Quinolones 71
Ch. 6 Other Targets of Antibacterial Drugs 79
Sect. III Antibiotic Resistance 89
Ch. 7 Natural and Producer Immunity versus Acquired Resistance 91
Ch. 8 Enzymatic Destruction or Modification of the Antibiotic by Resistant Bacteria 107
Ch. 9 Antibiotic Resistance by Efflux Pumps 125
Ch. 10 Antibiotic Resistance by Replacement or Modification of the Antibiotic Target 143
Sect. IV Antibiotic Biosynthesis 157
Ch. 11 Regulation of Antibiotic Biosynthesis in Producer Organisms 159
Ch. 12 Polyketide Antibiotic Biosynthesis: Assembly-Line Enzymology 175
Ch. 13 Enzymatic Assembly Lines for Nonribosomal Peptide Antibiotics 195
Ch. 14 Biosynthesis of Other Classes of Antibiotics 221
Sect. V New Strategies for Finding Novel Antibiotics and Extending Their Lifetimes 235
Ch. 15 New Looks at Targets 237
Ch. 16 New Molecules 271
Ch. 17 Contexts and Challenges for the Use of New Antibiotics 285
References 297
Index 329
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