Antibody Therapeutics

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Antibody Therapeutics is a comprehensive evaluation of progress toward using humanized antibodies as a new generation of therapeutics. The humanized antibodies that have led the way in product approval are discussed as case studies, offering an insight into the preclinical and clinical data acquired during the regulatory approval process. Leading experts offer their findings as examples of what works and what does not, saving you time and making your research more cost effective. This book is essential reading ...
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1997 Hard cover Illustrated. New in New dust jacket. Sewn binding. Cloth over boards. 366 p. Contains: Illustrations. CRC Pharmacology & Toxicology: Basic & Clinical Aspects.

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Overview

Antibody Therapeutics is a comprehensive evaluation of progress toward using humanized antibodies as a new generation of therapeutics. The humanized antibodies that have led the way in product approval are discussed as case studies, offering an insight into the preclinical and clinical data acquired during the regulatory approval process. Leading experts offer their findings as examples of what works and what does not, saving you time and making your research more cost effective. This book is essential reading for researchers, clinicians, development and regulatory staff in pharmaceutical and biotechnology companies, and hospital staff, including policy and decision makers. It also provides postgraduate and medical students with an authoritative overview of the field.

The book contains black-and-white illustrations.

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Editorial Reviews

Booknews
Fifteen chapters evaluate progress toward using humanized antibodies as a new generation of therapeutics. The humanized antibodies that have led the way in product approval are discussed as case studies, offering an insight into the preclinical and clinical data acquired during the regulatory approval process. Contributors offer their findings as examples of what works and what doesn't, and provide critical appraisals of the progress and limitations to the use of humanized antibodies in infectious disease, immune suppression, autoimmune disease, and cancer. Annotation c. by Book News, Inc., Portland, Or.
Booknews
Surveys the impact of novel techniques in molecular biology on the understanding of antibody structure and function, such as rapid gene isolation, DNA sequencing, high-resolution X-ray, NMR structural analysis, and computer modeling, and relates how these technologies came together to allow conversion of rodent monoclonal antibody into an antibody with human structure. Discusses clinical studies with murine and chimeric monoclonal antibodies, bacteriophage antibody display libraries, and transgenic mice with human immunoglobins. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

Table of Contents

1 The Structure of Antibodies 1
2 Antibody Modeling and De Novo Antibody Design 19
3 Immunotherapy 29
4 Clinical Studies with Murine and Chimeric Monoclonal Antibodies 39
5 Human Monoclonal Antibodies 69
6 Humanized Antibodies 85
7 Bacteriophage Antibody Display Libraries 111
8 Transgenic Mice with Human Immunoglobulins 129
9 New Perspectives for Antibody Therapeutics 141
Index 151
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