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Anticlastogens in Mammalian and Human Cells
     

Anticlastogens in Mammalian and Human Cells

by Erich Gebhart, Ruben M. Arutyunyan
 

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Anticlastogens in Mammalian and Human Cells covers research on the protection of chromosomes from the action of chemical mutagens by use of natural and synthetic antimutagens, which, because of their specific action on clastogenic damage are called anticlastogens. Based on an introductory chapter on nature and mode of formation of chromosome aberrations induced

Overview

Anticlastogens in Mammalian and Human Cells covers research on the protection of chromosomes from the action of chemical mutagens by use of natural and synthetic antimutagens, which, because of their specific action on clastogenic damage are called anticlastogens. Based on an introductory chapter on nature and mode of formation of chromosome aberrations induced by chemical and also physical mutagens, the action of anticlastogens is discussed in detail. A definition and delineation of the term anticlastogenesis is followed by considerations on the various possibilities of classifying anticlastogens. Attention is paid to the action of anticlastogens in mammalian and human cell culture systems, in vivo data on anticlastogens are presented in great detail, as are the actions of anticlastogens on induced sister chromatid exchanges in various test systems. A mainly historical side-glance at the action of anticlastogens on chromosome damage induced by ionizing radiation is taken. The practical consequences of the findings on anticlastogenic action are extensively discussed as aspects of further research.

Editorial Reviews

Booknews
Two geneticists, one Russian, one German, report on their research into reducing the amount of chromosome damage induced by mutagens. The immediate concern is to protect normal human cells during chemical or radiation therapy for cancer, but such studies also contribute to the possibility of preventing cancer chemically, especially in high-risk groups. They consider the principles of clastogenic action, data from experiments with various anticlastogens, and practical consequences of their findings. At nearly a dollar a page, it must be important. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Product Details

ISBN-13:
9783642762314
Publisher:
Springer Berlin Heidelberg
Publication date:
07/31/2012
Edition description:
Softcover reprint of the original 1st ed. 1991
Pages:
125
Product dimensions:
6.10(w) x 9.25(h) x 0.01(d)

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