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Doody's Review ServiceReviewer: Katalin Mikecz, MD, PhD (Rush Medical College of Rush University)
Description: This volume of Advances in Protein Chemistry provides up-to-date information about the ultrastructure and function of antigen-binding molecules: antibodies and T-cell receptors. The book is structured to represent most topics central to the molecular basis of immune recognition.
Purpose: Written by internationally recognized leaders in the field, whose prestigious discoveries represent milestones in contemporary immunology research and the advancement of science, this book is an authentic review of current knowledge in molecular immunology.
Audience: Researchers, teachers, and students in immunology, biology, and biochemistry will benefit from this appealing and highly informative book.
Features: Topics include functional analysis of interactions of antibodies and T-cell receptors with antigenic epitopes; the principles of diversification and maturation of the immune response; catalytic antibodies; and the use of x-ray crystallography, nuclear magnetic resonance, and computational biochemistry as research tools for the structural analysis and three-dimensional modeling of antigen binding molecules. Each chapter starts with background information on the topic, often containing anecdotal details about the history of momentous scientific developments. The topics are properly explored and explained; many of them address fascinating new directions in research and novel applications of the molecular tools that are not usually dealt with in immunology handbooks. This is a type of book that will certainly inspire new avenues of immunological research. Because of extensive referencing, the book is also a useful source for the expert audience.
Assessment: The book is highly recommended for libraries and bookstores of academic and biomedical research institutions.