Antigen Binding Molecules: Antibodies and T-Cell Receptors / Edition 1

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Overview

Topics Covered Include:

X-ray crystallography of ligands.

Catalytic antibodies.

Nature of the antigen.

Antibody binding sites.

Maturation of the immune response.

Computational biochemistry of antibodies and T-cell receptors.

Antigen-specific T-cell receptors and their reactions.

Key Features
* X-Ray Crystallography of Ligands
* Catalytic Antibodies
* Nature of the Antigen
* Antibody Binding Sites
* Maturtion of the Immune Response
* Computational Biochemistry of Antibodies and
• T-Cell Receptors
* Antigen-Specific T-Cell Receptors and Their Reactions

Audience: Molecular biologists, biochemists, immunologists, and biophysicists.

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Editorial Reviews

From The Critics
Reviewer: Katalin Mikecz, MD, PhD (Rush Medical College of Rush University)
Description: This volume of Advances in Protein Chemistry provides up-to-date information about the ultrastructure and function of antigen-binding molecules: antibodies and T-cell receptors. The book is structured to represent most topics central to the molecular basis of immune recognition.
Purpose: Written by internationally recognized leaders in the field, whose prestigious discoveries represent milestones in contemporary immunology research and the advancement of science, this book is an authentic review of current knowledge in molecular immunology.
Audience: Researchers, teachers, and students in immunology, biology, and biochemistry will benefit from this appealing and highly informative book.
Features: Topics include functional analysis of interactions of antibodies and T-cell receptors with antigenic epitopes; the principles of diversification and maturation of the immune response; catalytic antibodies; and the use of x-ray crystallography, nuclear magnetic resonance, and computational biochemistry as research tools for the structural analysis and three-dimensional modeling of antigen binding molecules. Each chapter starts with background information on the topic, often containing anecdotal details about the history of momentous scientific developments. The topics are properly explored and explained; many of them address fascinating new directions in research and novel applications of the molecular tools that are not usually dealt with in immunology handbooks. This is a type of book that will certainly inspire new avenues of immunological research. Because of extensive referencing, the book is also a useful source for the expert audience.
Assessment: The book is highly recommended for libraries and bookstores of academic and biomedical research institutions.
From the Publisher
"The authority, originality, and editing of the reviews are first class."
--NATURE
"The Advances in Protein Chemistry series has been a major factor in the education of protein chemists."
--JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Katalin Mikecz
This volume of Advances in Protein Chemistry provides up-to-date information about the ultrastructure and function of antigen-binding molecules: antibodies and T-cell receptors. The book is structured to represent most topics central to the molecular basis of immune recognition. Written by internationally recognized leaders in the field, whose prestigious discoveries represent milestones in contemporary immunology research and the advancement of science, this book is an authentic review of current knowledge in molecular immunology. Researchers, teachers, and students in immunology, biology, and biochemistry will benefit from this appealing and highly informative book. Topics include functional analysis of interactions of antibodies and T-cell receptors with antigenic epitopes; the principles of diversification and maturation of the immune response; catalytic antibodies; and the use of x-ray crystallography, nuclear magnetic resonance, and computational biochemistry as research tools for the structural analysis and three-dimensional modeling of antigen binding molecules. Each chapter starts with background information on the topic, often containing anecdotal details about the history of momentous scientific developments. The topics are properly explored and explained; many of them address fascinating new directions in research and novel applications of the molecular tools that are not usually dealt with in immunology handbooks. This is a type of book that will certainly inspire new avenues of immunological research. Because of extensive referencing, the book is also a useful source for the expert audience. The book is highly recommended for libraries and bookstores of academic andbiomedical research institutions.

4 Stars! from Doody
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Product Details

Table of Contents

H.N. Eisen, Y. Sykulev, and T.J. Tsomides, Antigen-Secific T-Cell Receptors and Their Reactions with Natural Ligands: Complexes Formed by Peptides with Major Histocompatibility Complex Proteins.
E.A. Padlan, X-Ray Crystallography of Antibodies.
H.M. McConnell and M. Martinez-Yamout, Insight into Antibody Combining Sites using Nuclear Magnetic Resonance and Spin Label Haptens.
J. Novotny and J. Bajorath, Computational Biochemical of Antibodies and T-CellReceptors.
P.G. Schultz, Catalytic Antibodies.
M. Sela and I. Pecht, The Nature of the Antigen.
J.S Huston, M.N. Margolies, and E. Haber, Antobody Binding Sites.
C. Milstein and M.S. Neuberger, Maturation of the Immune Response.
Chapter References.
Author Index.
Subject Index.
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