Antimicrobial Chemotherapy / Edition 5

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"The essence of this book is to describe the basic properties of antibiotics and other antimicrobial agents and to discuss the principles underlying the rational use of antimicrobial agents in the management of infection - in order to encourage good prescribing habits in doctors throughout the world."--BOOK JACKET.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Lisa A Clough, MD (University of Kansas Medical Center)
Description: This introductory textbook outlines fundamental principles of antimicrobial therapy. This edition emphasizes the importance of understanding basic antimicrobial properties as well as the complex issues of microbial resistance in order to achieve good prescribing habits.
Purpose: The authors' intent is to introduce medical students and other health professionals to the principle of rational antimicrobial design. Their aim is to provide the necessary knowledge base required for recognizing and implementing good practice. This goal is exceedingly important today with the increasing pressure of antimicrobial resistance, decreasing number of new agents, and the increase in the types and complexity of illness. Antibiotic stewardship is an essential foundation which must be taught early in training.
Audience: The intended audience is medical students, residents, and other healthcare professionals involved in antimicrobial prescribing. The book is written at a level appropriate for this audience. The authors are educators and writers with extensive publications in this field.
Features: The book is appropriately divided into four sections that represent a systematic approach to good prescribing practices. Responsible prescribers must have an understanding of basic properties of antimicrobial classes and individual agents, mechanisms of antimicrobial resistance, and general principles of use as well as specific therapeutic indications. The section on properties of antimicrobial agents is a concise guide with careful inclusion of clinically practical information. The figures and tables for the most part highlight important concepts. The authors include periodic highlighted bulleted reviews (which they term prescriber's survival kit) that do not seem particularly useful. Unique to most introductory antimicrobial texts is a chapter on guidelines, formularies and policies. The authors are correct in acknowledging that guidelines and policies now have significant impact on antibiotic prescribing and these documents need to be thoughtfully reviewed and used accurately. Instructing learners early on regarding appropriate use of these resources is important. The final section on specific therapeutic indications provides not only specific treatment options but also the appropriate background and rational for making such choices. Throughout the book, the authors are careful to include a historical context for drug development and use. This appropriately provides readers additional rationale for proper antibiotic choices.
Assessment: This is a useful overview of antimicrobial therapy. The authors provide essential information to answer several basic questions each prescriber should ask when writing antimicrobial prescriptions: what agent am I choosing, why am I choosing it, and how can I make a better choice. The information is updated in the hopes of giving healthcare providers a sound knowledge base to continue good prescribing practices.
From the Publisher

"This is a useful overview of antimicrobial therapy. The authors provide essential information to answer several basic questions each prescriber should ask when writing antimicrobial prescriptions; what agent am I choosing, why am I choosing it, and how can I make a better choice."--Doody's

"The book is well written and is easy to read...The comprehensive nature of the book means necessarily that some attention is paid to areas of antimicrobial chemotherapy that are beyond the scope of most physicians."--British Journal of Hospital Medicine

"An excellent blend of basic science and clinical application; it targets a variety of healthcare professionals and fulfils multiple roles...The facts are clearly presented using a captivating approach, and the authors have succeeded in imparting a large volume of information in a compact and unintimidating manner...An excellent, up-to-date text."--Journal of Antimicrobial Chemotherapy

William Michael Dunne
This is a comprehensive yet concise review of antimicrobial agents and their appropriate use in the management of infectious diseases. The text artfully blends historical perspectives with a thorough overview of the contemporary repertoire of anti-infective drugs available to the practitioner. "The purpose is to provide readers with basic yet technically insightful perspectives on the evolution of antimicrobial chemotherapy and the current state of the art. This work fills a definite void by providing a bridge between introductory level offerings and references designed specifically for the infectious diseases specialist. The text succeeds in its mission by organizing subject matter into easily digested and logically progressive chapters. "The target audience should include medical students, residents, general practitioners and clinicians in subspecialties other than infectious diseases. Pharmacists, medical technologists, and clinical microbiologists will also find this book to be a handy reference. The text provides an excellent educational tool for the undergraduate and medical school levels as well. "The book can be divided into three basic sections. The first covers descriptions and mechanisms of action of the various classes of antimicrobial agents. The last section is a synopsis of contemporary anti-infective chemotherapy categorized by disease type and organ system. The middle section is a collection of miscellaneous but useful topics including pharmacokinetics, resistance mechanisms, and the role of the laboratory as a guide for therapy. One of the more notable features is the use of well organized and descriptive tables. On the downside, the section on laboratory testing isquite dated and limits the appeal of the text to medical technologists and clinical microbiologists. "This book should find a useful place in the libraries of the target audience. It should be especially appealing to medical students and generalists who are confounded by the ever-increasing array of newly developed and released antimicrobial agents and the equally perplexing emergence of microbial resistance. This work covers those subjects with remarkable ease and clarity.
David W. Hecht
This is the third edition of a widely published book covering the general characteristics and principles governing the use of antimicrobial agents in clinical medicine. The goal is to introduce medical students to the general properties of antibiotics, the role of the laboratory in clinical decision making, the importance of antibiotic resistance, and the basic principles in antibiotic treatment strategies. The objectives are important ones for all practitioners and are generally met in this introductory text. It is appropriately suited as an introductory text for freshman or sophomore medical and pharmacy students. The references are a list of suggested readings divided into topics. Overall, the list is somewhat broad and is limited to more recent contributions to the field. Despite the emphasis on antimicrobial resistance, there are few suggested readings on this topic. This edition is a significantly updated version of a widely known text that introduces the beginning medical student to the broad topic of antimicrobial chemotherapy. It provides an assimilation of diverse topics covering the general properties of antibiotics and their use and will serve as a ready source of general information on this important topic. This latest edition includes substantial new material and is an important replacement of the earlier texts.

2 Stars from Doody
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Product Details

  • ISBN-13: 9780198570165
  • Publisher: Oxford University Press
  • Publication date: 2/22/2007
  • Edition description: REV
  • Edition number: 5
  • Pages: 504
  • Product dimensions: 9.20 (w) x 6.10 (h) x 0.90 (d)

Meet the Author

David Greenwood is Emeritus Professor of Antimicrobial Science at the University of Nottingham Medical School, having been Professor for 16 years. He has written, edited and contributed to many books in the field of Antimicrobial Science. Peter Davey is current President of the British Society for Antimicrobial Chemotherapy, Professor of Pharmoeconomics at the University of Dundee and Honorary Consultant in Infectious Diseases, Tayside University Hospitals. Professor Roger Finch has authored more than 300 papers covering the fields of antimicrobial chemotherapy, lower respiratory tract infections and the pathogenesis of staphylococcal disease. He is currently European Editor of Current Opinion in Infectious Diseases and was formerly Editor-in-Chief of the Journal of Antimicrobial Chemotherapy. Professor Mark Wilcox is Professor of Medical Microbiology at the University of Leeds, and is a Medical Microbiology Consultant. He is the Clinical Director of Pathology and the Director of Infection Prevention and Control for The Leeds Teaching Hospitals.

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Table of Contents

List of contributors
Historical introduction 1
Pt. I General Properties of Antimicrobial Agents 9
1 Inhibitors of bacterial cell wall synthesis 11
2 Inhibitors of bacterial protein synthesis 29
3 Synthetic antibacterial agents and miscellaneous antibiotics 46
4 Antifungal agents 59
5 Antiprotozoal and anthelminthic agents 66
6 Antiviral agents 77
7 Antiretroviral agents 93
Pt. II Laboratory Aspects of Antimicrobial Therapy 99
8 Antibiotic sensitivity testing and assay 101
9 Antibiotic interactions 118
10 Use of the laboratory 126
Pt. III Resistance to Antimicrobial Agents 135
11 The problem of resistance 137
12 Mechanisms of acquired resistance 145
13 The genetics of resistance 156
14 Control of the spread of resistance 164
Pt. IV General Principles of Usage of Antimicrobial Agents 173
15 General principles of the treatment of infection 175
16 Pharmacokinetics 183
17 Prescribing for children and the elderly 193
18 Adverse reactions to antibiotics 200
19 Chemoprophylaxis 212
Pt. V The Therapeutic Use of Antimicrobial Agents 223
20 Respiratory tract infections 225
21 Urinary infections 235
22 Gastrointestinal infections 242
23 Bacteraemia and endocarditis 253
24 Skin and soft-tissue infections 272
25 Bone and joint infections 280
26 Mycobacterial disease 287
27 Meningitis and brain abscess 301
28 Viral infections 318
29 Infection in immunocompromised patients 335
30 Sexually transmitted infections 345
31 Parasitic diseases 354
32 Topical use of antimicrobial agents 368
33 Postscript: The development and marketing of antimicrobial drugs 376
Recommendations for further reading 387
Index 391
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