Antisense Therapeutics / Edition 2

Antisense Therapeutics / Edition 2

by M. Ian Phillips
     
 

ISBN-10: 1617374210

ISBN-13: 9781617374210

Pub. Date: 11/10/2010

Publisher: Springer-Verlag New York, LLC

Announcement of the complete sequencing of the human genome in April 2003 demonstrated the presence of thousands of targets for antisense oligonucleotides and opened the way to hundreds of preclinical animal studies and some 20 ongoing clinical trials. In this second edition of Antisense Therapeutics, a team of leading researchers and clinical scientists

Overview

Announcement of the complete sequencing of the human genome in April 2003 demonstrated the presence of thousands of targets for antisense oligonucleotides and opened the way to hundreds of preclinical animal studies and some 20 ongoing clinical trials. In this second edition of Antisense Therapeutics, a team of leading researchers and clinical scientists demonstrate the new reality of antisense and RNA inhibition for treating a broad range of diseases. The authors show how antisense oligonucleotides are being designed and studied in relation to hypertension, various cancers, inflammatory bowel disease, brain disorders, the blood-brain barrier, and drug delivery. Highlights include RNA-based therapies for many diseases, up-to-date methods and applications, and insight into the enormous potential to provide a new generation of drugs.

Highly practical and disease oriented, Antisense Therapeutics, Second Edition offers not only a primer for a new generation of drug discovery researchers, but also an illuminating exploration of the potential in exploiting RNA inhibition for novel human therapeutics.

Product Details

ISBN-13:
9781617374210
Publisher:
Springer-Verlag New York, LLC
Publication date:
11/10/2010
Series:
Methods in Molecular Medicine Series, #106
Edition description:
Softcover reprint of hardcover 2nd ed. 2005
Pages:
344
Product dimensions:
5.98(w) x 9.02(h) x 0.03(d)

Table of Contents

Part I. Introduction

Antisense Therapeutics: A Promise Waiting to be Fulfilled

M. Ian Phillips

Antisense Inhibition: Oligonucleotides, Ribozymes, and siRNAs

Y. Clare Zhang, Meghan M. Taylor, Willis K. Samson, and M. Ian Phillips

Part II. Cardiovascular

Local Application of Antisense for Prevention of Restenosis

Patrick L. Iversen, Nicholas Kipshidze, Jeffrey W. Moses, and Martin B. Leon

Antisense Therapeutics for Hypertension: Targeting the Renin-Angiotensin System

M. Ian Phillips and Birgitta Kimura

Antisense Strategies for the Treatment of Heart Failure

Sian E. Harding, Federica del Monte, and Roger J. Hajjar

Part III. Cancer

Clinical Studies of Antisense Oligonucleotides for Cancer Therapy

Rosanne M. Orr and F. Andrew Dorr

Antisense Therapy in Clinical Oncology: Preclinical and Clinical Experiences

Ingo Tamm

Radionuclide-Peptide Nucleic Acid Diagnosis and Treatment of Pancreatic Cancer

Eric Wickstrom, Xiaobing Tian, Nariman V. Amirkhanov, Atis Chakrabarti, Mohan R. Aruva, Ponugoti S. Rao, Wenyi Qin, Weizhu Zhu, Edward R. Sauter, and Mathew L. Thakur

Suppression of Pancreatic and Colon Cancer Cells by Antisense K-ras RNA Expression Vectors

Kazunori Aoki, Shumpei Ohnami, and Teruhiko Yoshida

Induction of Tumor Cell Apoptosis and Chemosensitization by Antisense Strategies

Manuel Rieber and Mary Strasberg-Rieber

Utility of Antioncogene Ribozymes and Antisense Oligonucleotides in Reversing Drug Resistance

Tadao Funato

Part IV. Blood-Brain Barrier

Transport of Antisense Across the Blood-Brain Barrier

Laura B. Jaeger and William A. Banks

Part V. Dermal

Transdermal Delivery of Antisense Oligonucletoides

Rhonda M. Brand and Patrick L. Iversen

Part VI. Drugs

Antisense Strategies for Redirection of Drug Metabolism: Using Paclitaxel as a Model

Vikram Arora

Part VII. Gastrointestinal

Antisense Oligonucleotide Treatment of Inflammatory Bowel Diseases

Bruce R. Yacyshyn

Part VIII. Hepatitis

Optimizing Electroporation Conditions for the Intracellular Delivery of Morpholino Antisense Oligonucleotides Directed Against the Hepatitis C Virus Internal Ribosome Entry Site

Ronald Jubin

Index

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