BN.com Gift Guide

Antisense Therapeutics / Edition 2

Paperback (Print)
Buy New
Buy New from BN.com
$126.24
Used and New from Other Sellers
Used and New from Other Sellers
from $110.24
Usually ships in 1-2 business days
(Save 26%)
Other sellers (Paperback)
  • All (3) from $110.24   
  • New (3) from $110.24   

Overview

A timely primer on the new reality of antisense and RNA inhibition for treating a broad range of diseases. The authors show how antisense oligonucleotides are being designed and studied in relation to hypertension, various cancers, inflammatory bowel disease, brain disorders, the blood-brain barrier, and drug delivery. Highlights include RNA-based therapies for many diseases, up-to-date methods and applications, and insight into the enormous potential to provide a new generation of drugs.

Read More Show Less

Editorial Reviews

Doody's Review Service
Reviewer: Bryan L. Copple, PhD (University of Kansas Medical Center)
Description: Rather than describing mechanisms of antisense action, this book focuses on current and future therapeutic uses of antisense oligonucleotides. It is organized into disease states, which shows the potential broad applications of these therapeutics to many disease states. This second edition updates the first edition published in 1996.
Purpose: The purpose is to address the potential use of antisense oligonucleotides as therapeutic agents to treat diseases in humans. A comprehensive review of current and past clinical trials is needed to show that these agents are more than just tools for research, but are potentially valuable therapeutic drugs. This book clearly demonstrates that the field of antisense research has significantly progressed in the past 10 years towards the goal of making antisense oligonucleotides valuable therapeutic drugs.
Audience: The book would be useful for both researchers and practitioners who have an interest in understanding the potential therapeutic utility of these compounds. The author is clearly an authority in the field and has extensive knowledge about the potential of antisense therapeutics.
Features: Antisense approaches that are currently under investigation to treat various diseases are covered. In particular, this book discusses the usefulness of antisense to treat cardiovascular disease, cancer, and various gastrointestinal disorders. What is useful to readers is that each chapter discusses the experimental approach that each investigator took to evaluate the usefulness of these agents to treat different disease states. Beyond this, the book also evaluates newer methods of antisense inhibition, such as ribozymes and siRNAs, and discusses the potential of these agents as therapeutics in the future. It might have been useful, however, to include one or two chapters on the use of siRNAs in vivo since this new mechanism of antisense action was discussed in the book; there are many such examples in the literature. One shortcoming is that many of the chapters begin with a recapitulation of the mechanism by which antisense oligonucleotides work. Since the first two chapters address this in detail, this could have been eliminated from each of the chapters.
Assessment: Antisense oligonucleotides are used by most investigators as tools for research. What is often lost is the potential of these compounds as drugs to treat diseases. This book does an excellent job of showing the reader that antisense oligonucleotides could be valuable therapeutic drugs in the future. The first edition focused primarily on mechanisms of antisense action. Therefore, this edition was needed to show how antisense research has progressed towards the clinic in the years since.
From The Critics
Reviewer: Bryan L. Copple, PhD (University of Kansas Medical Center)
Description: Rather than describing mechanisms of antisense action, this book focuses on current and future therapeutic uses of antisense oligonucleotides. It is organized into disease states, which shows the potential broad applications of these therapeutics to many disease states. This second edition updates the first edition published in 1996.
Purpose: The purpose is to address the potential use of antisense oligonucleotides as therapeutic agents to treat diseases in humans. A comprehensive review of current and past clinical trials is needed to show that these agents are more than just tools for research, but are potentially valuable therapeutic drugs. This book clearly demonstrates that the field of antisense research has significantly progressed in the past 10 years towards the goal of making antisense oligonucleotides valuable therapeutic drugs.
Audience: The book would be useful for both researchers and practitioners who have an interest in understanding the potential therapeutic utility of these compounds. The author is clearly an authority in the field and has extensive knowledge about the potential of antisense therapeutics.
Features: Antisense approaches that are currently under investigation to treat various diseases are covered. In particular, this book discusses the usefulness of antisense to treat cardiovascular disease, cancer, and various gastrointestinal disorders. What is useful to readers is that each chapter discusses the experimental approach that each investigator took to evaluate the usefulness of these agents to treat different disease states. Beyond this, the book also evaluates newer methods of antisense inhibition, such as ribozymes and siRNAs, and discusses the potential of these agents as therapeutics in the future. It might have been useful, however, to include one or two chapters on the use of siRNAs in vivo since this new mechanism of antisense action was discussed in the book; there are many such examples in the literature. One shortcoming is that many of the chapters begin with a recapitulation of the mechanism by which antisense oligonucleotides work. Since the first two chapters address this in detail, this could have been eliminated from each of the chapters.
Assessment: Antisense oligonucleotides are used by most investigators as tools for research. What is often lost is the potential of these compounds as drugs to treat diseases. This book does an excellent job of showing the reader that antisense oligonucleotides could be valuable therapeutic drugs in the future. The first edition focused primarily on mechanisms of antisense action. Therefore, this edition was needed to show how antisense research has progressed towards the clinic in the years since.
Read More Show Less

Product Details

  • ISBN-13: 9781617374210
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 11/10/2010
  • Series: Methods in Molecular Medicine Series , #106
  • Edition description: Softcover reprint of hardcover 2nd ed. 2005
  • Edition number: 2
  • Pages: 344
  • Product dimensions: 9.00 (w) x 6.00 (h) x 0.76 (d)

Table of Contents

Part I. Introduction

Antisense Therapeutics: A Promise Waiting to be Fulfilled

M. Ian Phillips

Antisense Inhibition: Oligonucleotides, Ribozymes, and siRNAs

Y. Clare Zhang, Meghan M. Taylor, Willis K. Samson, and M. Ian Phillips

Part II. Cardiovascular

Local Application of Antisense for Prevention of Restenosis

Patrick L. Iversen, Nicholas Kipshidze, Jeffrey W. Moses, and Martin B. Leon

Antisense Therapeutics for Hypertension: Targeting the Renin-Angiotensin System

M. Ian Phillips and Birgitta Kimura

Antisense Strategies for the Treatment of Heart Failure

Sian E. Harding, Federica del Monte, and Roger J. Hajjar

Part III. Cancer

Clinical Studies of Antisense Oligonucleotides for Cancer Therapy

Rosanne M. Orr and F. Andrew Dorr

Antisense Therapy in Clinical Oncology: Preclinical and Clinical Experiences

Ingo Tamm

Radionuclide-Peptide Nucleic Acid Diagnosis and Treatment of Pancreatic Cancer

Eric Wickstrom, Xiaobing Tian, Nariman V. Amirkhanov, Atis Chakrabarti, Mohan R. Aruva, Ponugoti S. Rao, Wenyi Qin, Weizhu Zhu, Edward R. Sauter, and Mathew L. Thakur

Suppression of Pancreatic and Colon Cancer Cells by Antisense K-ras RNA Expression Vectors

Kazunori Aoki, Shumpei Ohnami, and Teruhiko Yoshida

Induction of Tumor Cell Apoptosis and Chemosensitization by Antisense Strategies

Manuel Rieber and Mary Strasberg-Rieber

Utility of Antioncogene Ribozymes and Antisense Oligonucleotides in Reversing Drug Resistance

Tadao Funato

Part IV. Blood-Brain Barrier

Transport of Antisense Across the Blood-Brain Barrier

Laura B. Jaeger and William A. Banks

Part V. Dermal

Transdermal Delivery of Antisense Oligonucletoides

Rhonda M. Brand and Patrick L. Iversen

Part VI. Drugs

Antisense Strategies for Redirection of Drug Metabolism: Using Paclitaxel as a Model

Vikram Arora

Part VII. Gastrointestinal

Antisense Oligonucleotide Treatment of Inflammatory Bowel Diseases

Bruce R. Yacyshyn

Part VIII. Hepatitis

Optimizing Electroporation Conditions for the Intracellular Delivery of Morpholino Antisense Oligonucleotides Directed Against the Hepatitis C Virus Internal Ribosome Entry Site

Ronald Jubin

Index

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)