Antithrombotics: Pathophysiological Rationale for Pharmacological Interventions

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Product Details

  • ISBN-13: 9789401055406
  • Publisher: Springer Netherlands
  • Publication date: 4/30/2013
  • Series: Developments in Cardiovascular Medicine Series, #126
  • Edition description: Softcover reprint of the original 1st ed. 1991
  • Edition number: 1
  • Pages: 261
  • Product dimensions: 6.14 (w) x 9.21 (h) x 0.58 (d)

Table of Contents

1. Platelet activation and aggregation: rationale for combining antithrombotic drugs.- 2. Role of nitric oxide in endothelial cell - platelet interactions.- 3. Platelets and megakaryocytes in vascular disease.- 4. Thrombosis in relation to atherosclerosis.- 5. Pharmacological inhibition of the ADP-GP IIb/IIIa-fibrinogen pathway of platelet aggregation.- 6. Calcium fluxes in platelets and endothelial cells, mechanisms and functional significance.- 7. Inhibition of platelet function by cyclic nucleotides and cyclic nucleotide-dependent protein kinases.- 8. Pharmacological modification of platelet-derived cyclooxygenase product formation and its consequences for platelet-vessel wall interactions.- 9. Antithrombotics and the lipoxygenase pathway.- 10. Pathological expressions of platelet-vessel wall interactions: implications of serotonin.- 11. The involvement of PAF in thrombotic events.- 12. Prostaglandins and -analogs in the treatment of platelet-vessel wall interaction.- 13. Adjuvant agents to enhance and sustain reperfusion with t-PA: studies in experimental dog models.- 14. Effect of dietary marine lipids on (anti-)thrombotic mechanisms.

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