Anxiety Disorders: Pathophysiology and Pharmacological Treatment

Overview

In this book, the discussion of the normal and pathological aspects of anxiety is critically examined. A chapter on the molecular basis of anxiety is included, outlining the potential of such approach in the discovery of novel effective pharmacological interventions. The face validity, predictability and usefulness of animal models in the design of valid new efficacious products are discussed. Separate chapters dedicated to each particular type of anxiety such as generalized anxiety disorder, social phobia, ...
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Overview

In this book, the discussion of the normal and pathological aspects of anxiety is critically examined. A chapter on the molecular basis of anxiety is included, outlining the potential of such approach in the discovery of novel effective pharmacological interventions. The face validity, predictability and usefulness of animal models in the design of valid new efficacious products are discussed. Separate chapters dedicated to each particular type of anxiety such as generalized anxiety disorder, social phobia, posttraumatic stress disorder, panic and obsessive-compulive disorder are included.
This book should be of benefit to psychiatrists, clinical psychologists,
general practitioners, nurses, students and all those engaged in neuropsychiatric research.
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Editorial Reviews

Doody's Review Service
Reviewer: Lavinia L. Myers, MD (Rush University Medical Center)
Description: This is an interesting new book reviewing the spectrum of anxiety disorders, with particular focus on pathophysiology and treatment.
Purpose: The purpose is to provide a discussion of normal and pathological anxiety, as well as a detailed review of the major anxiety disorders. It includes a survey of current research, including animal models of anxiety, and discusses the usefulness and validity of this research for clinical practice. This is an important review of an area of great clinical interest. The book largely meets its overall objective.
Audience: This book is intended for psychiatrists, clinical psychologists, general practitioners, nurses, students, and others engaged in neuropsychiatric research, and will be useful for a more detailed review of the anxiety disorders. The authors are credible and knowledgeable in this field.
Features: The book contains numerous tables and charts throughout to illustrate the written material. These enhance the readability of the book. Each chapter lists numerous references, which are thorough and relevant.
Assessment: This is a thorough, useful book for practitioners and researchers as a comprehensive review of the current theories on etiology of anxiety disorders as well as the most recent research models. It also provides practical treatment guidelines in pharmacological, behavioral, and psychological modalities, citing evidence for the usefulness of each dicussed intervention. This book helps bring together the theoretical as well as practical aspects of understanding and treating anxiety disorders.

3 Stars from Doody
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Product Details

  • ISBN-13: 9783034894609
  • Publisher: Birkhauser Basel
  • Publication date: 11/28/2012
  • Edition description: Softcover reprint of the original 1st ed. 2002
  • Pages: 298
  • Product dimensions: 7.00 (w) x 10.00 (h) x 0.68 (d)

Table of Contents

1:Normal and pathological anxiety.- 1 What is anxiety?.- 1.1 Anxiety in children.- 1.2 Anxiety in the elderly.- 1.3 Personality and anxiety.- 1.4 Cognitive aspects of anxiety.- 1.4.1 Gray neurophysiological model of anxiety.- 1.5 Comorbidity of anxiety disorders.- 1.6 Anxiety scales.- 2 Relevance of laboratory research on anxiety disorders.- 3 Genetic factors and brain imaging.- 4 Management.- 5 Discussion.- 2:Biological basis of anxiety and strategies for pharmacological innovation.- 1 Introduction.- 2 Neurobiology of anxiety disorders.- 2.1 Generalised anxiety disorder.- 2.2 Panic disorder.- 2.3 Social phobia.- 2.4 Post-traumatic stress disorder.- 2.5 Obsessive-compulsive disorders.- 3 Recent development and future anxiolytics.- 3.1 5-HT receptors.- 3.2 GABA receptors.- 3.3 Neuropeptide (CCK, CRF, NPY and NK) receptors.- 3.4 Glutamatergic pathways.- 3.5 Opioid receptors.- 3.6 Neurosteroids.- 3.7 Equilibrium between GABA-benzodiazepine and other receptors.- 3.8 Use of mutant mice.- 4 Discussion.- 3:Generalised anxiety disorder.- 1 Introduction.- 2 Diagnostic.- 3 The phenomenon of worry.- 4 Neurobiology.- 4.1 Imaging studies.- 4.2 Genetics.- 5 Physiopathology.- 6 Epidemiology and natural course.- 7 Treatment.- 7.1 Psychological.- 7.2 Biofeedback.- 7.3 Pharmacological.- 7.3.1 Benzodiazepines.- 7.3.2 Buspirone.- 7.3.3 Venlafaxine.- 7.3.4 SSRIs.- 7.3.5 Tricyclics.- 7.3.6 Other drugs.- 7.3.7 Algorithm for treatment.- 8 Methodology for clinical investigation.- 9 Discussion.- 4:Social phobia.- 1 Introduction.- 2 Diagnosis and comorbidity.- 2.1 Subtypes.- 2.2 Differential diagnosis.- 2.3 Comorbidity.- 2.4 Epidemiology.- 2.5 Natural history.- 2.6 Childhood and adolescence versus adult social phobia.- 3 Pathophysiology.- 3.1 Genetic.- 3.2 Neurophysiology.- 3.3 Neuroimaging.- 3.4 Environment.- 3.5 Gender and cultural differences.- 4 Treatments.- 4.1 Psychological.- 4.2 Pharmacological.- 4.3 Comparison, combination of drug versus cognitive-behavioral therapy.- 4.4 Algorithm for treatment.- 5 Methodology of clinical investigations.- 5.1 Rating scales.- 5.2 Self-assessment questionnaires.- 5.3 Clinician/computer-administered scales.- 5.4 Health Outcome Assessments.- 5.5 Assessment of recovery.- 6 Discussion.- 5:Panic disorder.- 1 Introduction.- 2 Diagnosis and aetiology.- 2.1 Comorbidity.- 2.2 Epidemiology.- 3 Pathophysiology.- 3.1 Autonomic and central nervous system dysfunctions.- 3.2 Brain imaging.- 3.3 Respiratory function and carbon dioxide sensitivity.- 3.4 Genetic.- 3.5 Impact on cognitive processes.- 4 Treatments.- 4.1 Psychological.- 4.2 Pharmacological.- 4.2.1 Benzodiazepines.- 4.2.2 Tricyclic antidepressants.- 4.2.3 SSRIs.- 4.2.4 Other treatments.- 4.2.5 Algorithm for treatment.- 5 Methodology for clinical investigation.- 5.1 Psychometric scales.- 5.2 Assessing response and remission.- 6 Discussion.- 6:Obsessive-compulsive disorder.- 1 Introduction.- 2 Diagnostic.- 2.1 Comorbidity.- 2.2 Epidemiology.- 2.3 Natural history.- 3 Physiopathology.- 3.1 Neurobiology.- 3.2 Brain imaging.- 3.3 Genetics.- 3.4 Cognitive dysfunctions.- 4 Treatment.- 4.1 Psychological treatment.- 4.2 Pharmacological treatment.- 4.2.1 Clomipramine.- 4.2.2 SSRI and the 5-HT receptors.- 4.2.3 Addition of atypical neuroleptics.- 4.2.4 Course of therapy.- 4.2.5 Children.- 4.2.6 Some cultural differences in treatment practice.- 5 Methodology for clinical investigation.- 5.1 Psychometric scales.- 6 Discussion.- 7:Posttraumatic stress disorder.- 1 Introduction.- 2 Epidemiology.- 3 Comorbidity.- 4 Physiological and neurological abnormalities associated with PTSD.- 4.1 Physiological abnormalities.- 4.2 Neurobiology and brain abnormalities.- 5 Cognitive dysfunction associated with PTSD.- 5.1 Assessment of PTSD.- 5.2 Attentional bias: The emotional Stroop test.- 5.3 Memory.- 6 Treatment of PTSD.- 6.1 Psychotherapeutic approach.- 6.1.1 Exposure therapy.- 6.1.2 Anxiety management programs.- 6.1.3 Cognitive therapy.- 6.1.4 Eye movement and desensitisation reprocessing.- 6.2 Biofeedback.- 6.3 Pharmacological approach.- 6.3.1 Tricyclics.- 6.3.2 Selective serotonin reuptake inhibitors.- 6.3.3 Anticonvulsants.- 6.3.4 ?-blocker and a2-agonist.- 6.3.5 ?l-antagonists.- 6.3.6 Buspirone.- 6.3.7 Other drugs.- 6.3.8 New research strategy in pharmacotherapy of PTSD.- 7 Discussion.- 8:Phobic disorders.- 1 Introduction.- 2 Epidemiology.- 3 Genetics.- 4 Treatment.- 4.1 Psychological.- 4.2 Biofeedback.- 4.3 Pharmacological.- 5 Discussion.- 9:Laboratory models of anxiety.- 1 Introduction.- 2 Biological animal models.- 2.1 GABAergic transmission and benzodiazepine receptor function.- 2.2 5-HT receptor knockouts.- 2.3 Corticotropin-releasing hormone mutation and CRH-receptor knockouts.- 2.4 Genetically selected alcohol-preferring rats.- 3 Behavioural animal models.- 3.1 Anxiety.- 3.1.1 Elevated plus-maze.- 3.1.2 Elevated T-maze.- 3.1.3 The holeboard test.- 3.1.4 Stress-induced hyperthermia.- 3.1.5 Fear potentiated startle.- 3.1.6 Burying behaviour test.- 3.1.7 Stretched attend posture test.- 3.1.8 Light-dark transition test.- 3.1.9 Social interaction.- 3.1.10 Ultrasonic distress vocalisation.- 3.1.11 A primate model.- 3.2 Panic disorder.- 3.2.1 Periaqueductal gray model.- 3.2.2 The mouse defence test battery.- 3.2.3 Other new behavioural models.- 3.3 Generalised anxiety disorder.- 3.4 Obsessive-compulsive disorder.- 3.5 Posttraumatic stress disorder.- 3.6 Effects of the antidepressants in the models.- 4 Human models.- 4.1 Some models of anxiety.- 4.1.1 The video-recorded Stroop colour word test.- 4.1.2 Fear potentiated startle.- 4.2 Generalised anxiety disorder.- 4.3 Panic disorder.- 5 Issues relevant to some non-benzodiazepine anxiolytics.- 5.1 5-HT receptors.- 5.2 Cholecystokinin receptors.- 6 Discussion.- 10:Discussion and perspectives.- Future perspectives.
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