Apoptosis and Cancer Chemotherapy / Edition 1

Apoptosis and Cancer Chemotherapy / Edition 1

by John A. Hickman
     
 

This collection of thoughtful and provocative articles focused on the key issues in apoptosis, ranges from the role of apoptosis in defining the response of authentic tumor populations to chemotherapeutic agent s to the mechanisms coupling DNA damage to the activation pathway of a poptosis. It reviews the profusion of new signaling, modulating, and e ffector

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Overview

This collection of thoughtful and provocative articles focused on the key issues in apoptosis, ranges from the role of apoptosis in defining the response of authentic tumor populations to chemotherapeutic agent s to the mechanisms coupling DNA damage to the activation pathway of a poptosis. It reviews the profusion of new signaling, modulating, and e ffector molecules now implicated in apoptosis and whether other routes to "programmed" cell death may exist. Also addressed are the nature o f the molecules that will either constitute targets for future drugs o r influence the efficacy of current therapies, as well as mechanistic questions on the control of apoptosis.

Product Details

ISBN-13:
9780896037434
Publisher:
Springer-Verlag New York, LLC
Publication date:
04/08/1999
Series:
Cancer Drug Discovery and Development Series
Edition description:
1999
Pages:
358
Product dimensions:
9.21(w) x 6.14(h) x 0.81(d)

Table of Contents

Foreword
Preface
Contributors
1Does Apoptosis Contribute to Tumor Cell Sensitivity to Anticancer Agents?1
2p53, Apoptosis, and Chemotherapy21
3The Role of p53 in Chemosensitivity37
4Function of the p53 Gene Family: A Holistic Perspective53
5Mismatch Repair Deficiency, Apoptosis, and Drug Resistance69
6Involvement of c-Abl Tyrosine Kinase in Apoptotic Response to Anticancer Agents87
7Bcl-2 Family Proteins: Relative Importance as Determinants of Chemoresistance in Cancer99
8Bax, a Death Effector Molecule: Its Role in Development and Oncogenesis117
9Bax, a Proapoptotic Protein Forming Channels in Mitochondria129
10Mechanism of Action of the Proapoptotic Gene Bak143
11Killers or Clean-Up Crew: How Central Are the Central Mechanisms of Apoptosis?157
12Role of CD95 (APO-1/Fas) System in Chemotherapy175
13Insulin-Like Growth Factor-1 Receptor as a Target for Anticancer Therapy189
14Drug Resistance and the Survival Niche: Survival Signals Combine to Suppress Drug-Induced Apoptosis in B-Lymphoma Cells205
15Chemotherapy, Tumor Microenvironment, and Apoptosis223
16Molecular Regulation and Therapeutic Implications of Cell Death in Prostate Cancer241
17Chemotherapy and Apoptosis in the Ovary: Cancer Treatment Comes with a Price257
18Role of Bcl-2 Family Members in Homeostasis, in Toxicology in Normal Intestine, and for Prognosis of Colonic Carcinomas275
19Apoptosis and Breast Cancer291
20Role of Apoptosis in Human Neuroblastomas305
21Response of Testicular Tumors to Chemotherapy: Relative Role of Drug-DNA Interactions and Apoptosis319
Concluding Remarks: Has the Information Explosion on Apoptosis Affected Clinical Practice?331
Index333

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