Apoptosis and Cancer Chemotherapy / Edition 1

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This collection of thoughtful and provocative articles focused on the key issues in apoptosis, ranges from the role of apoptosis in defining the response of authentic tumor populations to chemotherapeutic agent s to the mechanisms coupling DNA damage to the activation pathway of a poptosis. It reviews the profusion of new signaling, modulating, and e ffector molecules now implicated in apoptosis and whether other routes to "programmed" cell death may exist. Also addressed are the nature o f the molecules that will either constitute targets for future drugs o r influence the efficacy of current therapies, as well as mechanistic questions on the control of apoptosis.

The book contains black-and-white illustrations.

The realization that responses of tumors to chemotherapy also depends on so-called “downstream” events has created much interest in regulators of apoptosis as determinants of drug action. And, because these regulators also play key roles in multistage carcinogenesis, they provide important potential targets for new therapies. Acknowledged leaders in the field have written thoughtful and up-to-date reviews, as well as personal views of some of the conundrums facing the field, such as finding the prognostic value of molecules like p53 and bcl-2 in determining responses to therapies and how these molecules function in different cellular contexts. This series of short reviews, with prioritized reading recommendations, presents a contemplative assessment of the field.

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Editorial Reviews

Twenty-one reviews provide a balanced assessment of recent discoveries that serves as a foundation for further research. Topics include the role of p53 in chemosensitivity; involvement of c-Abl tyrosine kinase in apoptotic response to anticancer agents; The role of Bax in development and oncogenesis; insulin-like growth factor-1 receptor as a target for anticancer therapy; molecular regulation and therapeutic implications of cell death in prostate cancer; and apoptosis and breast cancer. Concluding remarks ask whether the information explosion on apoptosis has affected clinical practice. Annotation c. Book News, Inc., Portland, OR booknews.com
From the Publisher
"This book provides a balanced view on the current knowledge on the relation between apoptosis and chemotherapy...The greatest merit of the book is to gather the different opinions about the relevance of apoptosis in chemosensitivity...Another positive aspect of this book is the effort made in having a relatively recent update presentation in most chapters, what is quite a remarkable achievement in a field where new molecules and pathways are continuously being discovered and described. Furthermore, the main concepts are discussed throughout this book in a balanced fashion, combining solid literature with some speculation, sometimes rather provocative as well...a book that pays off, since it provides an informative journey through a complex and interesting field. This book should be recommended not only for medical oncologists interested in molecular and mechanistic discussion about chemosensitivity, but also for basic scientists working in the field of drug-induced apoptosis."-Annals of Oncology

"This book of 21 chapters is a clinically relevant assessment of the chemotherapeutic significance of apoptosis in cancer treatment...the chapters are well written, relatively up to date and reasonably well illustrated."-Cell Biology International

"This book is of value to many scientists as a current reference to a complicated field. It also provides a balanced view of the field and warns investigators that complexity is the norm and over-simplification is a laboratory phenomenon."-Oncology

"...This book is an excellent critical summary of where the field is today...This is an excellent book with up to date references useful to graduate students, clinicians and researchers who, in a few hours reading would gain a broad overview of the current field."-Today's Life Science

"This volume represents the most comprehensive work devoted to the subject, and the editors have done an outstanding job of recruiting some of the most prominent researchers in the field....the book is an outstanding resource and should be extremely valuable to all investigators interested in cancer research."-Quarterly Review of Biology

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Product Details

  • ISBN-13: 9780896037434
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 4/8/1999
  • Series: Cancer Drug Discovery and Development Series
  • Edition description: 1999
  • Edition number: 1
  • Pages: 358
  • Product dimensions: 9.21 (w) x 6.14 (h) x 0.81 (d)

Table of Contents

1 Does Apoptosis Contribute to Tumor Cell Sensitivity to Anticancer Agents? 1
2 p53, Apoptosis, and Chemotherapy 21
3 The Role of p53 in Chemosensitivity 37
4 Function of the p53 Gene Family: A Holistic Perspective 53
5 Mismatch Repair Deficiency, Apoptosis, and Drug Resistance 69
6 Involvement of c-Abl Tyrosine Kinase in Apoptotic Response to Anticancer Agents 87
7 Bcl-2 Family Proteins: Relative Importance as Determinants of Chemoresistance in Cancer 99
8 Bax, a Death Effector Molecule: Its Role in Development and Oncogenesis 117
9 Bax, a Proapoptotic Protein Forming Channels in Mitochondria 129
10 Mechanism of Action of the Proapoptotic Gene Bak 143
11 Killers or Clean-Up Crew: How Central Are the Central Mechanisms of Apoptosis? 157
12 Role of CD95 APO-1/Fas System in Chemotherapy 175
13 Insulin-Like Growth Factor-1 Receptor as a Target for Anticancer Therapy 189
14 Drug Resistance and the Survival Niche: Survival Signals Combine to Suppress Drug-Induced Apoptosis in B-Lymphoma Cells 205
15 Chemotherapy, Tumor Microenvironment, and Apoptosis 223
16 Molecular Regulation and Therapeutic Implications of Cell Death in Prostate Cancer 241
17 Chemotherapy and Apoptosis in the Ovary: Cancer Treatment Comes with a Price 257
18 Role of Bcl-2 Family Members in Homeostasis, in Toxicology in Normal Intestine, and for Prognosis of Colonic Carcinomas 275
19 Apoptosis and Breast Cancer 291
20 Role of Apoptosis in Human Neuroblastomas 305
21 Response of Testicular Tumors to Chemotherapy: Relative Role of Drug-DNA Interactions and Apoptosis 319
Concluding Remarks: Has the Information Explosion on Apoptosis Affected Clinical Practice? 331
Index 333
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