Apoptosis in Cardiac Biology

by Heribert Schunkert, G.A.J. Riegger

Overview

Apoptosis or programmed cell death is increasingly considered to be a major factor in the development and progression of cardiovascular disease. In patients with heart failure the activation of apoptosis may result in the loss of irreplaceable cardiac myocytes promoting the clinical course of the syndrome. Moreover, in the coronary arteries inflammation and apoptosis may weaken critical structures of the vessel wall leading to plaque rupture and, subsequently, to myocardial infarction. Given these deleterious consequences, it seems almost paradoxical that programmed cell death is an active process that, if initiated under physiological circumstances, is essential for both coordinated tissue growth or destruction of malignant cells.
Apoptosis in Cardiac Biology, written by a team of internationally renowned researchers, gives a timely synopsis of basic mechanisms, cellular and structural targets and, finally, clinical implications of programmed cell death in the heart. The expert authors of this volume give concise overviews on general and cell-specific aspects of programmed cell death in cardiac myocytes and fibroblasts, as well as in vascular smooth muscle and endothelial cells. Furthermore, novel therapeutic options arising from the outstanding pathophysiological significance of cardiac apoptosis are presented.
This comprehensive review of Apoptosis in Cardiac Biology will be of interest to both clinicians and basic researchers who are active in the fields of cardiology and atherosclerosis.

Product Details

ISBN-13:	9781475782622
Publisher:	Springer US
Publication date:	03/24/2013
Series:	Basic Science for the Cardiologist , #5
Edition description:	Softcover reprint of the original 1st ed. 2000
Pages:	354
Product dimensions:	6.10(w) x 9.25(h) x 0.03(d)

About the Author

Schunkert, Heribert (Univ of Regensburg); Riegger, Gunter A.J. (Univ of Regensburg)

Table of Contents

Basic Mechanisms of Apoptosis.- Death receptors and their ligands.- Regulation of apoptosis by CD 137.- Reactive oxygen species and apoptosis.- Oncogenes and p53.- BCL-2 family members and mihondria.- Inhibition of cardiac myocyte apoptosis by gp130-dependent cytokines.- Cell cycle regulation and apoptotic cell death.- Caspase cascades and caspase targets.- Apoptosis: a distinctive form of cell death.- Cellular Targets in the cardiovascular system.- Apoptosis and cell cycle in endothelial cells.- Endurance under stress and cardioprotective functions by cardiac fibroblasts.- Cardiac myocytes.- Cardiac myocytes and fibroblasts exhibit differential sensitivity to apoptosis-inducing stimuli.- Apoptosis in Cardiac Disorders.- Hypertension as a cardiovascular proliverative disorder.- Apoptosis in human atherosclerosis.- Apoptosis in myocardial infarction.- Pro-inflammatory and pro-apoptotic factors in heart failure.- Molecular mechanisms of cardiac myocardial remodeling during aging. Role of apoptosis.- Apoptosis during cardiac surgery.- Therapeutical Options.- New opportunities for heart disease therapeutics.- Beta blocker therapy and prevention of apoptosis.- Apoptosis in cardiac myocytes - Role of the renin-angiotensin-system.- Estrogens and the prevention of cardiac apoptosis.- Open questions on apoptosis in cardiac biology.

Editorial Reviews

Considering that cardiovascular disease is the leading cause of morbidity and mortality in industrialized nations, greater clinical and research attention is being directed to apoptosis<-->a basic biological process governing the lifecycle of cells. In patients with heart failure, the activation of programmed cell death may result in a chain of events leading to myocardial infarction. Paradoxically, apoptosis is also essential for coordinated tissue growth and destruction of malignant cells. Two dozen papers by 49 international contributors provide a timely synopsis of the basic mechanisms of apoptosis, cellular targets in the cardiovascular system, and therapeutic options arising from the significance of cardiac apoptosis. Among the illustrations are electron microscope views of human heart biopsies. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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