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Doody's Review ServiceReviewer: John A. Stanford, PhD (University of Kansas Medical Center)
Description: This book provides a theoretical and practical overview of microdialysis in preclinical and clinical pharmaceutical research. The chapters address the utility of microdialysis as a way to sample biological molecules of interest across body systems as well as in water, soil, and plants.
Purpose: It is intended as an overview of microdialysis in pharmacokinetic and pharmacodynamic studies in various organ systems. The author also includes special applications for microdialysis, including in vitro studies, drug-drug interactions, and environmental monitoring.
Audience: The book is targeted at pharmaceutical researchers, and it would be beneficial for researchers ranging from graduate students to professionals.
Features: Particularly well covered are the analytical considerations for microdialysis sampling (chapter 3 by Nandi, Kuhnline and Lunte) and dopamine and amino acid neurotransmitter sampling (chapters 4-6). Given that these topics represent the majority of microdialysis research, their presence is critical in a book like this. Other strengths of the book include the wide range of body systems (brain, muscle, fat, liver, blood, skin) and special topics (tumor response, in vitro studies, drug-drug interactions, environmental monitoring) that are covered. Though very interesting, the chapter on water, soil, and plant microdialysis is a curious inclusion. If I had to cite a shortcoming, it would be a lack of treatment of anesthetized vs. freely-moving microdialysis and related issues such as postimplantation recovery time. Also, a few of the chapters covering microdialysis sampling in humans (chapters 11 and 12 on adipose and diabetes, respectively) could have benefitted from some treatment of preclinical animal research as a basis for translational work in their topics. These are just minor shortcomings, however.
Assessment: This book will serve as a valuable reference for pharmaceutical researchers and it will be a logical companion to the Handbook of Behavioral Neuroscience series volume, Handbook of Microdialysis: Methods, Applications and Perspectives, Westerink and Cremers (Academic Press, 2007). While that book focuses almost exclusively on brain microdialysis, this book extends these considerations to other organ systems.