Applications of Pharmacokinetic Principles in Drug Development / Edition 1

Applications of Pharmacokinetic Principles in Drug Development / Edition 1

by Rajesh Krishna
     
 

ISBN-10: 0306477661

ISBN-13: 9780306477669

Pub. Date: 10/31/2003

Publisher: Springer US

This book presents a collection of articles that represent individual and expert perspectives in both preclinical and clinical development, including case studies on real-life examples of successful drugs that add value to the pharmacokinetic principles learned and applied. Unlike existing books that focus on pharmacokinetic theory, the current book emphasizes

Overview

This book presents a collection of articles that represent individual and expert perspectives in both preclinical and clinical development, including case studies on real-life examples of successful drugs that add value to the pharmacokinetic principles learned and applied. Unlike existing books that focus on pharmacokinetic theory, the current book emphasizes application of pharmacokinetic principles in new drug development.

Product Details

ISBN-13:
9780306477669
Publisher:
Springer US
Publication date:
10/31/2003
Edition description:
2004
Pages:
556
Product dimensions:
7.01(w) x 10.00(h) x 0.06(d)

Table of Contents

1. Efficient and Effective Drug Development; W.A. Colburn, G. Heath.
2. Bioanalytical Methods: Challenges and Opportunities in Drug Development; M.L. Powell, S.E. Unger.
3. Prediciting Human Oral Bioavalibility using In Silico Models; L. X. Yu, et al.
4. Drug Metabolism in Preclinical Development; M.W. Sinz.
5. Interspecies Scaling; T. Lavé, et al.
6. Human Drug Absorption Studies in Early Development; D.V. Prior, et al.
7. Food-Drug Interactions: Drug Development Considerations; D. Fleisher, L. Reynolds.
8. Global Regulatory and Biopharmaceutics Strategies in New Drug Development: Biowaivers; E. Gupta, E. Yamashita.
9. Special Population Studies in Clinical Development: Pharmacokinetic Considerations; J.M. Kovarik.
10. Drug-Drug Interactions; S.M. Huang.
11. Pharmacokinetic/Pharmacodynamic Modeling in Drug Development; S. Rohatagi, et al.
12. Population Pharmacokinetic and Pharmacodynamic Modeling; R. Jelliffe, et al.
13. Role of Preclinical Metabolism and Pharmacokinetics in the Development of Celecoxib; S.K. Paulson, T.J. Maziasz.
14. The Role of Clinical Pharmacology and of Pharmacokinetics in the Development of Alendronate - A Bone Resorption Inhibitor; A.G. Porras, B.J. Gertz.
15. Optimizing Individualized Dosage Regimens of Potentially Toxic Drugs; R.W. Jelliffe, et al. Appendix. Index.

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