Applied Biopharmaceutics & Pharmacokinetics, Sixth Edition / Edition 6

Applied Biopharmaceutics & Pharmacokinetics, Sixth Edition / Edition 6

5.0 3
by Leon Shargel, Andrew Yu, Susanna Wu-Pong
     
 

ISBN-10: 007160393X

ISBN-13: 9780071603935

Pub. Date: 05/04/2012

Publisher: McGraw-Hill Professional Publishing

A comprehensive textbook on the theoretical and practical applications of biopharmaceutics and pharmacokinetics

The field’s leading text for more than three decades

Applied Biopharmaceutics & Pharmacokinetics, Sixth Edition provides you with a basic understanding of the principles of biopharmaceutics and pharmacokinetics and applies

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Overview

A comprehensive textbook on the theoretical and practical applications of biopharmaceutics and pharmacokinetics

The field’s leading text for more than three decades

Applied Biopharmaceutics & Pharmacokinetics, Sixth Edition provides you with a basic understanding of the principles of biopharmaceutics and pharmacokinetics and applies these principles to drug product development, drug product performance and drug therapy. The revised and updated sixth edition is unique in teaching basic concepts that relate to understanding the complex issues associated with safe and efficacious drug therapy.

Written by authors who have both academic and clinical experience, Applied Biopharmaceutics & Pharmacokinetics will help you to:

  • Understand the basic concepts in biopharmaceutics and pharmacokinetics.
  • Use raw data and derive the pharmacokinetic models and parameters that best describe the process of drug absorption, distribution, and elimination
  • Critically evaluate biopharmaceutic studies involving drug product equivalency and unequivalency
  • Design and evaluate dosage regimens of drugs, using pharmacokinetic and biopharmaceutic parameters
  • Detect potential clinical pharmacokinetic problems and apply basic pharmacokinetic principles to solve them

Practical problems and clinical examples with discussions are included in each chapter to help you apply these principles to patient care and drug consultation situations. Chapter Objectives, Chapter Summaries, and Frequently Asked Questions along with additional application questions appear within each chapter to identify and focus on key concepts. Most of the chapters have been revised to reflect our current understanding of drug product performance, bioavailability, bioequivalence, pharmacokinetics, pharmacodynamics, and drug therapy.

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Product Details

ISBN-13:
9780071603935
Publisher:
McGraw-Hill Professional Publishing
Publication date:
05/04/2012
Edition description:
List
Pages:
811
Product dimensions:
7.60(w) x 9.40(h) x 1.50(d)

Related Subjects

Table of Contents

Preface
1Review of Mathematical Fundamentals1
2Introduction to Biopharmaceutics and Pharmacokinetics29
3One-Compartment Open Model47
4Multicompartmental Models67
5Physiologic Factors Related to Drug Absorption99
6Biopharmaceutic Considerations in Drug Product Design129
7Modified-Release Drug Products169
8Targeted Drug Delivery Systems and Biotechnological Products205
9Pharmacokinetic Model of Oral Absorption223
10Bioavailability and Bioequivalence247
11Physiologic Drug Distribution and Protein Binding281
12Drug Elimination and Clearance Concepts325
13Hepatic Elimination of Drugs353
14Intravenous Infusion399
15Multiple-Dosage Regimens419
16Nonlinear Pharmacokinetics449
17Application of Pharmacokinetics in Clinical Situations475
18Dosage Adjustment in Renal and Hepatic Disease531
19Relationship Between Pharmacokinetic and Pharmacodynamics573
20Physiologic Pharmacokinetic Models, Mean Residence Time, and Statistical Moment Theory607
App. A: Statistics643
App. BApplication of Computers in Pharmacokinetics653
App. CSolutions to Frequently Asked Questions (FAQ) and Learning Questions667
App. DGuiding Principles for Human and Animal Research727
App. EPopular Drugs and Pharmacokinetic Parameters731
App. F: Glossary737
Index739

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Applied Biopharmaceutics & Pharmacokinetics, Sixth Edition 5 out of 5 based on 0 ratings. 1 reviews.
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