Applied Clinical Pharmacokinetics / Edition 2

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Overview

The easiest and most trusted way to learn the clinical application of pharmacokinetics

5 STAR DOODY'S REVIEW!

"This is an important reference that teaches clinically relevant pharmacokinetic dosing and therapeutic drug monitoring tools. This second edition includes updated information on dosing immunosuppressants, as well as dosing concepts in pediatric and hemodialysis patients. The book is intended as an instructive tool in pharmacokinetics for healthcare practitioners who wish to learn these concepts and apply them in their clinical practice. The book satisfies its objectives, outlining important pharmacokinetic concepts in an organized and easy to understand fashion. It is also written by a pharmacist with extensive experience in pharmacokinetics and includes clinically pertinent pearls for individual drugs.

This second edition succeeds at providing updated information on pharmacokinetic concepts. The book presents information in a manner that allows readers to teach themselves about pharmacokinetic dosing and to update their knowledge about clinically relevant concepts for the medications. These concepts are critical because medications are far too often dosed without individual patient characteristics (weight, age, concomitant medications) in mind. It is important to individualize dosing based on pharmacokinetic methods, to monitor levels, and to adjust subsequent dosing based on peaks, troughs, renal, and hepatic function." — Doody's

The most current, hands-on book in the field, Applied Clinical Pharmacokinetics gives you clear and useful coverage of drug dosing and drug monitoring that no other text can match. It offers the latest standardized techniques and approaches to patient-specific dosing plus new information on more recent pharmacokinetically monitored drugs.

Written by a nationally recognized authority in pharmacokinetics, Applied Clinical Pharmacokinetics provides essential information covered in pharmaceutics, pharmacokinetics, therapeutics, and clinical pharmacy courses. It can be also be used as a clinical refresher to brush up on key concepts and procedures.

FEATURES

  • NEW! High-yield sections on dosing strategies in all chapters
  • NEW! Up-to-date, ready-to-use information on monitored drugs
  • Valuable coverage of drug dosing in special populations, including patients with renal and hepatic disease, obesity, and congestive heart failure and patients on dialysis
  • All the information that you need on drug categories such as antibiotics, cardiovascular agents, anticonvulsants, and immunosuppressants
  • Tools that simplify learning throughout, such as an introductory chapter on clinical pharmacokinetic and pharmacodynamic concepts, examples of calculations, and problems with answers and explanations at the end of each chapter
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Editorial Reviews

Doody's Review Service
Reviewer: Melissa M. Ranieri, BS, PharmD (Temple University School of Pharmacy)
Description: This book covers pharmacokinetic dosing for clinically relevant drugs in an organized and complete fashion. It includes basic concepts in pharmacokinetics and pharmacodynamics, as well as detailed chapters on individual medications. Each chapter contains tables that provide a reference for certain pharmacokinetic concepts, as well as cases and examples that reinforce pharmacokinetic dosing methods.
Purpose: This is an important reference that teaches clinically relevant pharmacokinetic dosing and therapeutic drug monitoring tools. This second edition includes updated information on dosing immunosuppressants, as well as dosing concepts in pediatric and hemodialysis patients. The book is intended as an instructive tool in pharmacokinetics for healthcare practitioners who wish to learn these concepts and apply them in their clinical practice. The book satisfies its objectives, outlining important pharmacokinetic concepts in an organized and easy to understand fashion. It is also written by a pharmacist with extensive experience in pharmacokinetics and includes clinically pertinent pearls for individual drugs.
Audience: Clinical practitioners who wish to learn clinical pharmacokinetics are the intended audience, including pharmacists, physicians, nurse practitioners, and physician assistants. It includes information that is critical for practitioners to learn and apply to patient care as well as extensive examples and problems with solutions so readers can master the outlined pharmacokinetic concepts. The book can also be used by students who are learning pharmacokinetics and it would be an excellent text for teaching this course. Each chapter is well organized and includes basic as well as advanced pharmacokinetic information. However, the book truly succeeds in presenting this information in a way that is easy to comprehend. It is apparent that the text was written by a pharmacist with over 30 years of experience and who is a professor in pharmacokinetics at the University of Washington School of Medicine and Pharmacy. The information in each chapter is derived from the author's lectures in pharmacokinetics and includes clinically pertinent information for dosing important medications.
Features: Introductory chapters include basic concepts in pharmacokinetics and pharmacodynamics, but the majority of the book has chapters on individual medications. These chapters open with an overview of the drug, including indications, goal therapeutic ranges, adverse effects, and monitoring. Pharmacokinetic dosing methods are outlined with equations to calculate initial and subsequent dosing and extensive examples and problems allow readers to practice these calculations. One of the highlights of the book are the clinical pearls for individual drugs, including the optimal time to measure peak and trough concentrations, which side-effects are correlated with elevated peaks or troughs, and which drug concentrations are clinically relevant. Clinical manifestations of toxicity are also discusses, as well as factors that falsely elevate drug levels and detailed information on drug antidotes. Finally, drug interactions are included in each chapter, which alerts the reader which concomitant medications could affect the pharmacokinetics of the drug. Each chapter contains tables that summarize important information in an easy to reference manner, including half-life, volume of distribution, and clinical pearls in different disease states. Figures reinforce pharmacokinetic concepts that are outlined in the text.
Assessment: This second edition succeeds at providing updated information on pharmacokinetic concepts. The book presents information in a manner that allows readers to teach themselves about pharmacokinetic dosing and to update their knowledge about clinically relevant concepts for the medications. These concepts are critical because medications are far too often dosed without individual patient characteristics (weight, age, concomitant medications) in mind. It is important to individualize dosing based on pharmacokinetic methods, to monitor levels, and to adjust subsequent dosing based on peaks, troughs, renal, and hepatic function.

3 Stars from Doody
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Product Details

  • ISBN-13: 9780071476287
  • Publisher: McGraw-Hill Professional Publishing
  • Publication date: 5/23/2008
  • Edition description: Older Edition
  • Edition number: 2
  • Pages: 840
  • Product dimensions: 7.40 (w) x 9.30 (h) x 1.50 (d)

Meet the Author

Larry A. Bauer, PharmD, is a Professor in the Departments of Pharmacy and Laboratory Medicine at the University of Washington in Seattle, WA.

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Table of Contents

Pt. I Basic concepts

1 Clinical pharmacokinetic and pharmacodynamic concepts 3

2 Clinical pharmacokinetic equations and calculations 28

3 Drug dosing in special populations : renal and hepatic disease, dialysis, heart failure, obesity, and drug interactions 52

Pt. II Antibiotics

4 The aminoglycoside antibiotics 97

5 Vancomycin 207

Pt. III Cardiovascular agents

6 Digoxin 301

7 Lidocaine 356

8 Procainamide/N-acetyl procainamide 398

9 Quinidine 448

Pt. IV Anticonvulsants

10 Phenytoin 485

11 Carbamazepine 548

12 Valproic acid 563

13 Phenobarbital/primidone 599

14 Ethosuximide 626

Pt. V Immunosuppressants

15 Cyclosporine 649

16 Tacrolimus 682

Pt. VI Other drugs

17 Lithium 711

18 Theophylline 745

Index 803

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